“…What distinguishes our age from every other is not the world-flattening impact of communications, not the economic ascendance of China and India, not the degradation of our climate, and not the resurgence of ancient religious animosities. Rather, it is a frantically accelerating pace of change…”

Read the entire piece at http://lnkd.in/bYP2nDC

Whenever I talk about indefinite life extension, the science and tech behind its development, and the desire for individuals to have the ultimate choice of when and how long they wish to live and die, the radical left almost always resorts to the argument, “Yeah, that sounds great, but then the rich aren’t going to provide it for the 99%. They’ll only keep it for themselves and let us die off.” How is this not equivalent to the conspiracy theory that the 1% are withholding the cure for cancer to the general populace?

It’s a bullshit viewpoint, in my opinion. Yes, the 1% are greedy fucks who care more about profits than anything else, but then, I ask you, how do they expect to earn profits from an extinct species?

While you’re trying to figure out an answer for that, I also find the idea that nothing would result from this kind of oppression to be asinine. Why? Here’s a good example: Black Friday. Every year Black Friday customers gather in the hundreds and thousands in each city, literally rioting, fighting, and killing people, just so they can get their hands on consumer products that’ll be outdated by next year. So if the cure for aging is being withheld from the masses, what the fuck do you think the masses are going to do? Just go home and sob? Ha! There’d be warfare on the streets the next morning.

So do I believe that indefinite life extension will be withheld from the 99% by the 1%? No. Just like I don’t believe that the 1% are withholding the cure for cancer from the 99%.

The article above was originally published as a blog post on The Proactionary Transhumanist.

Each new technology revolutionizes how we approach life and what we do in it. Take my new Kindle Fire HD for example. Before, I simply picked up a book – whether it be hardback or paperback – and start reading. Usually if there was a busy day ahead of me, each time I picked up a book I’d simply read a chapter, bookmark it – a lot of the cases being “dog ears,” unfortunately – and place it to the side, ready for another chapter to be read for another time.

This was a relatively comfortable motion of life that I adhered to. I read a lot. Though of course there were the slight annoyances that could be made known, but were fortunately tolerable. For example, if you don’t have a real bookmark, you then have to ruin the pages by flapping down a top corner of the page you were last reading from. That was a slight nuisance. Another example being, given I had a busy day and thus in need of scheduling, the fact that I had no clue as to how long it would take me to read the chapter, then placed me in a unfortunate position of not knowing how my day will be handled. At times, though rare, I couldn’t even finish a chapter because it was taking too long and I had to get things done.

So back to my Kindle Fire, these slight annoyances as an avid reader have been completely expropriated! Most MOBI-formatted books are well organized and easily readable. So when I’m reading, the Kindle Fire allows me to simply tap the top right corner and instantly bookmarks the page I’m reading. No “dog ears,” no unnecessary pieces of paper needing to be bought to be used as one. If I’m curious as to how long the chapter I’m reading will take, I simply tap the bottom left corner and it not only gives me the # of minutes left in reading the chapter, but the number of hours it’ll take for me to read the entire book. It detects my reading pattern via its sensors and calculates an estimation of how long each page is read, each chapter, the entire book. I also quite enjoy the fact that it provides a % of how much the book I’ve read so far.

This changes a lot for me as a reader. And really, while I’ve labeled them as slight annoyances, thinking back, I’m not sure how I could’ve tolerated such things. Then again, my love for reading always dominated my desire for perfection. But before the Kindle, there were still such a thing as digital books, which were formatted as PDFs (Portable Document Format). I’ve got a LOT of PDFs on my laptop! But then PDFs are incapable of creating bookmarks, and they weren’t exactly mobile-oriented like a normal hardback/paperback book was. That was an even greater nuisance to reading than normal books provided.

Kindle, however, destroyed those annoyances. Completely. It’s really easy to carry around. It doesn’t take up much space at all. It carries thousands of books, and much more when accessing its cloud server. Its battery life is top notch. It detects and learns your reading pattern. It connects to your online accounts. It integrates itself into your life in mere minutes!

When it comes to a reader, it changes everything. And that is revolutionary!

The article above was originally published as a blog post on The Proactionary Transhumanist.

Here, the term ‘Radical Life Extension’ specifically means the abolition of aging. Without the process of aging, however it is defined, people will not suffer age-related degenerative conditions, and they will not die of old age. Therefore, the terms ‘Radical Life Extension’,’ Indefinite Lifespans’, and ‘cure of age-related diseases’, all convey the same meaning: a life without aging. It is important to emphasize that I consider the process of aging to be directly related to that of reproduction. I argue that the process of reproduction is necessarily implicated in the process of aging (in other words, aging happens because we need to reproduce), as explained in my argument number 3 below.

In this context, I would also like to remark that by ‘reproduction’ I specifically refer to sexual (i.e. genetic) reproduction. Evolution may still continue to use (or begin to use) other forms of reproduction such as memetic reproduction and reproduction of noemes.

The main thrust of my discussion is that we are now beginning to witness the first tentative steps leading away from the significance of procreative sexual intercourse and towards the global emergence of other, sustained, non-procreative sexual preferences.

Let me explore a series of logical arguments which lead to an inescapable conclusion. Note that I do not imply a sentient deity in my discussion. I do not infer any entity that possesses any conscious awareness which transcend the laws of nature.

Argument 1
Nature, through evolution, tends to progress towards higher levels of complexity. To put it another way, within natural laws there are basins of attraction which necessarily tend to cause a transition from simple to complex, and therefore lead to the emergence of new characteristics. The Belgian Cyberneticist Francis Heylighen has listed these characteristics in increasing order of complexity, as follows:
* mobility
* sensation
* learning
* intelligence
* morality
* mimicry
* language
* culture
* technology.

He states that “The idea is that all life, wherever it occurs in the universe, will develop those traits of universal fitness, in roughly the same chronological order. It means that those traits are built into the laws of nature. They are statistically inevitable. It is as if nature ‘wants’ us to go in a certain direction. This is what gives biological evolution its clear directionality”.

The above list is not final, and there is no implication that technology is the end stage of human evolution. The point I am making here is a general one: that evolution tends to higher complexity, whatever this complexity might be, in order to ensure survival within a specified niche.

Argument 2
Based on this list, it is obvious that we are currently on the highest stage of natural evolution, that of technology. There will certainly be higher end-points in the future. In fact, I can think of at least two such stages which we have not yet achieved, but at this point I argue that this has profound implications on the issues of aging and radical life extension. If the general direction of evolution is towards increasing complexity and survival, why do we age and die? The answer is straightforward. Within a tendency to progress from simple to complex, evolution has selected reproduction (and thus aging – see argument 3) as a mechanism for maximising the use of thermodynamical resources, and so to ensure the survival of the species.

Argument 3
Until now, the clear role of reproduction was to maximise the chances of survival and thus progress to a higher stage in the list above. However, in order for reproduction to be successful, the genetic code (germ-line) must be maintained. An inequality of resources available for repair and maintenance between germ line and somatic cells means that, while the integrity of the germ-line is fully guaranteed, that of somatic cells is not. Therefore we (our bodies) must age and die through aging. Survival is thus assured, albeit it is the survival of the germ-line and that of the species, and not the survival of our own individual selves.

Argument 4
The main tendency in nature (i.e. the direction of evolution), through a relentless progress of increasing complexity, is to stay alive. Ultimately, what matters is to survive. The basins of attraction mentioned above exist because they ensure survival. Reproduction is just a means for assuring survival in the face of adverse thermodynamical resources. If there was a way to survive without reproduction, then the process of reproduction would be drastically downgraded. We may be now able to survive, i.e. live (dramatically) longer, through the use of technology and not necessarily through reproduction. There are three types of technology that is relevant here:
* Biomedical Technology
* General mechanical technology (includes AI)
* Digital Communications Technology

I have argued elsewhere that it is this last type of technology that is the most promising in achieving Radical Life Extension. In humans, technology is both the result of natural selection and the cause of the end of natural selection.

Argument 5
If there are any signs that reproduction is being downgraded then it means that the above arguments are likely to be correct, and that the process of long individual survival has begun. One such preliminary sign is the decline in procreative sexual practice and the relatively widespread emergence of other practices or preferences. If nature somehow ‘senses’ that survival is now being assured through technology, then the pressure for finding a mate of the opposite sex and reproduce would be eased, allowing the widespread emergence of other non-reproductive sexual practices such as homosexuality, non-procreative polyamory, hedonist polysexuality or pansexuality. It is likely therefore that we are now entering a period of human evolution which will not entirely depend on reproduction. Reduced reproduction means that more resources are available to be passed on to the soma (body) and thus radical longevity becomes more likely.

Discussion
How can the technological environment in which one finds themselves impact sexuality? There is a train of logical arguments which answer this question:
• If we accept that evolution generally tends to higher complexity and sophistication (including technological sophistication) in order to increase survival, and
• If we accept that a stage of significant technological achievement has now been reached (or is likely to be reached within 20 years), and
• If, as long as the human species survives, it is immaterial whether its survival is achieved through reproduction or through any other means, and
• If one of these other means is technology,

then, it is also logical to assume that genetic reproduction is now less important than before because high complexity/intelligence can be achieved through technology and through the prolonged survival of the individually- enhanced human, and not necessarily through a random process of natural selection (birth/procreation/death). If genetic reproduction is now not as important as before, any tendency to conventional procreative sexuality will diminish. Thus, other sexual preferences and practices will become more common place.

And just to push the discussion further into the realms of speculation, one should wonder if the progressive global reduction of sperm count, the increased incidence of undescended testicles, and the first signs that men are becoming less ‘macho’, have any relationship with my argument. It may be hypothesized that, as the reproductive practice is now being downgraded, the health of male sexual organs has begun to be affected, in preparation for a procreative shutdown, at least in some sections of humanity.

Finally, I have been asked: Can using computers make me gay? This is a captious statement which is both true and false, but it helps illustrate a point. Based on the arguments above, increased engagement with technology at a significant level, and by a significant number of people, will have an impact on natural selection and thus on procreation. It will diminish the hitherto immense pressure to find a mate and have offspring, and so other sexual preferences will emerge globally. The discussion does not refer to single isolated individuals but to humankind as a whole.

For more information on our research in these areas see www.elpisfil.org.

This article was originally published here:
http://hplusmagazine.com/2013/11/26/sexuality-evolution-and-…-of-aging/

The Prospect of Immortality − Fifty Years Later
Editor: Charles Tandy, Ph.D.
Publisher: Ria University Press
Distributor: Ingram
Timeline: To be published in 2014 (fifty years after 1964)

CALL FOR CONTRIBUTORS

Please look at Dr. Tandy’s chapter-by-chapter summary of Robert Ettinger’s classic, The Prospect of Immortality or consult the 1964 volume directly. Notice that Ettinger’s book consists of eleven chapters devoted to the following eleven topics:

1.Death’s Reversibility
2.Cooling Down
3.Thawing Out
4.Today’s Choices
5.Religious Issues
6.Legal Issues
7.Economic Issues
8.Personal Identity
9.Immortality’s Usefulness
10.Immortality’s Ethics
11.Immortality’s Future

Please consider contributing SPECIFICALLY TO ONE of the eleven invited topics. If you are interested in contributing, the following approach is suggested:

1. Read, with understanding, all eleven chapters of Robert Ettinger’s Prospect of Immortality.
2. Determine which one chapter on which you wish to focus.
3. Consider how a new and up-to-date Ettinger or expert might write the chapter today so as to properly persuade readers to cryonics. Write a chapter proposal (but NOT yet a draft paper) aimed at updating and/or revising the chapter of your choice.
4. Submit your chapter proposal, along with your cv/resume, to Charles Tandy, Ph.D.) at <[email protected]>.

The foundation’s research methodology is based mainly upon the ELPIS hypothesis (www.elpistheory.info). The initials stand for ‘Extreme Lifespans through Perpetual –equalising Interventions’. I developed this hypothesis in 2010 whilst trying to examine the reason behind the presence of aging. It was clear that aging is not an essential component of our evolutionary development, and if we find ways to study why nature has developed it, we may then be able to eradicate it. Currently, the chances of us dying from aging are heavily against us. By developing suitable interventions, we may be able to equalise the odds against us dying (i.e. remove aging as a cause of death).

Our method is different from most existing approaches aiming to eliminate aging. We are mainly interested in the ‘connection-approach’ and not so much in the ‘component-approach’. We believe that it is important to study how the different components of the organism are interconnected and regulated, rather than just repair the individual components. It is the ‘why aging happens’ rather than the ‘how it happens’ that interests us most. In order to make this clear let me mention an analogy with poliomyelitis.

Polio
*How it happens? There is inflammation and necrosis leading to damage of motor neurons and, ultimately, muscle weakness and paralysis
* Why it happens? Because the poliovirus causes it

Aging
* How it happens? There is cellular and molecular damage through oxidation and glycation, as well as damage to mitochondria, DNA etc.
* Why it happens? Because evolution has selected reproduction (and thus aging) as a mechanism for maximising the use of thermodynamical resources, and so ensure the survival of the species.

In this analogy, the obvious cure for polio is to somehow eradicate the poliovirus itself, and not just keep repairing the already damaged motor neurons. And in the case of aging, the best tactic is to somehow change the reason why aging happens, instead of just keep repairing already existing damage.

Attempts such as SENS and similar, aim to repairing existing damage, were as we aim primarily to eliminate the evolutionary reasons behind aging in the first place. This is not to say that we are not at all interested in damage repair. In fact, one of our main projects deals with the repair problem. But, overall we want to explore the evolution of aging and not its secondary effects.

We see aging as a specific and well-defined process. Our aim is unambiguous: we seek to eliminate this particular process. By eliminating aging we will have a life without age-related disease and degeneration, and a lifespan without a predetermined end. We do not seek immortality. In order to be immortal, one has to totally and permanently eliminate all causes of death (not just reduce their incidence). We seek to eliminate aging as one of the causes of death. People will still die from any other cause. In this case, our lifespan would be ‘indefinite’ because the current absolute limit of around 110–120 years will be lifted. There would not be a pre-defined limit; therefore the lifespan would be indefinite. It will not be infinite. This distinction is crucial because it clarifies any ambiguity and vagueness in the terminology. We do not seek eternal youth. We merely concentrate on the process of aging as one of the many other causes of death, the same as other researchers concentrate on the cure for cancer or the cure for HIV infection.

Within ELPIs Foundation we have scientific advisors from a wide range of disciplines, including biomedicine, transhumanism, social sciences, neurosciences, complex systems, and systems biology. Our affiliate researchers are scientists who conduct research in their own facilities and share information and ideas with each other. We are always looking for visionary, ‘out-of the box’ scientific thinkers, those who ‘zoom out’ of reductionist views, and see aging in a wider perspective without being uncritically blinkered by existing dogma.

We ask questions such as: If aging happens because nature withholds resources from the soma and diverts these to the germ-line, how can we reverse this process and divert resources back to the soma in order to maximise biological repair? What is the role of digital hyperconnectivity of billions of humans (the Global Brain) in facilitating such a transition? Where does aging and the elimination of aging fit within an ever-evolving technological tendency of nature? Some ideas we currently explore are:
* Induced Whole-Body Somatic Cell Turnover, for regenerative repair
* Aging and evolutionary changes as applied to human sexual patterns, reproduction, ecosystems, society and the planet
* The role of energy, entropy and thermodynamics in metasystem transitions with regards to human longevity
*Theoretical aspects of Germ-line penetration

May symposium

In May 2014 we will be organising the second symposium on ‘Pathways to Indefinite Lifespans’ in Larnaca, Cyprus. This is a small, very select, highly focused meeting exploring the most cutting-edge research and ideas with regards to the total abolition of aging. We aim to discuss new insights and hypotheses in the fields of biomedical technology, evolutionary anthropology, complex systems, a hyperconnected society, and digital communications technology. The meeting will be accessible live online and will include both local and remote presentations. Those interested in coming need to contact me at: [email protected]. We are also exploring the possibility of offering PhD positions to exceptional candidates, in order to facilitate research in this area.

This article was originally published here: http://hplusmagazine.com/2013/11/05/defying-aging-the-elpis-…lifespans/

Men who are unemployed for more than two years show signs of faster ageing in their DNA, according to a study published today in the journal PLOS ONE.

Researchers at the University of Oulu, Finland and Imperial College, London arrived at this conclusion by studying blood samples collected from 5,620 men and women born in Northern Finland in 1966. The researchers measured the lengths of telomeres in their white blood cells, and compared them with the participants’ employment history for the prior three years, and found that extended unemployment (more than 500 days in three years) was associated with shorter telomere length.

Telomeres are repetitive DNA sequences at the ends of chromosomes, which protect the chromosomes from degrading. With every cell division, it appears that these telomeres get shorter. And the result of each shortening is that these cells degrade and age.

When cells are grown in a lab, their telomeres do indeed shorten each time the cells divide. This process can be used to find a cell’s “expiry date”, a prediction of when that cell will run out of telomeres and stop dividing. However, this does not seem to relate to the actual health of the cells.

In the new study, the researchers found that that on average, men who had been unemployed for more than two of the preceding three years were more than twice as likely to have short telomeres compared to men who were continuously employed. In women, there was no association between unemployment status and telomere length.

The researchers accounted for telomere length differences resulting from medical conditions, obesity, socio-economic status and early childhood environment.

Previous studies, noted by the study authors, have found a correlation between shorter telomeres and higher rates of age-related diseases like Type 2 diabetes and heart disease. The authors conclude that the reduction in these men’s telomeres may have been the result from the stress of long-term unemployment, adding to evidence of a direct connection between prolonged unemployment and poor health.

An abstract concept

Employment is something very abstract; an employed and unemployed body are apparently more or less the same. So it might seem surprising that such an abstract thing as employment can affect a body on the cellular level. But the same is true for how stimuli affect our brains: remote objects trigger electrochemical cascades in our visual system – and when we learn new things, gene expression in the brain changes. We are interactive creatures, with innumerable stimuli that are constantly shaping multiple processes in our bodies. In this sense, the hypothesis that employment experience has cellular effects is not surprising.

This was an association study, which means than under certain set of circumstances two variables are statistically linked. This study is therefore incapable of genuinely predicting whether unemployment is the cause, and short telomeres the effect. Perhaps the opposite is true: maybe people whose cells lose their telomeres also lose their jobs. More likely, an outside factor that shortens telomeres could have a limiting effect on success in the labour market. For example, such a factor might somehow contribute towards illness or pessimism.

Additionally, because the study was conducted in an isolated and genetically quite homogeneous population, the results of the study may be due to their genetic make-up as well as (or instead of) environmental effects.

In the end, we do not need a genetic study to know long-term unemployment is bad for people socially, medically and psychologically; there is plenty of evidence for that. Additionally, the bio-gerontology community (those who study the biological processes of ageing) recognises telomere attrition as one of the nine causes of the disease of ageing, including Type 2 diabetes and cardiovascular diseases.

Where this study does make a significant contribution is in recognising long-term, low-level stress as a major problem. In momentarily stressful situations, the instant fight-or-flight response stimulates us; but being under pressure for a long time with no relief wears us down. Prolonged stress is bad for memory and health, and could quite conceivably shorten telomeres – making an unemployed person significantly more unhealthy, with the effects persisting even after they get a job.

In the long run, what we really need to learn to slow or stop the ageing process is how to reduce or repair the damage done by stress.

The authors do not work for, consult to, own shares in or receive funding from any company or organisation that would benefit from this article. They also have no relevant affiliations.

This article was originally published at The Conversation.
Read the original article.

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RE.WORK Cities brings together the most influential technologists, entrepreneurs,
academics, business leaders, and government officials to collaborate and reshape our
future cities. Attendees will gain insight into breakthrough innovations that will have
an impact on our future urban areas through the world’s leading technologists and
decision-makers. Some of the new products and advances explored at RE.WORK will include progress in the internet of things, sensors, 3D printing, nanotechnology,
biotechnology, robotics, and artificial intelligence.

Use the discount code LIFEBOAT40 to get 40% off the attendance fee. As an extra bonus, you can apply to get a free ticket by sending a message to [email protected] with the subject “Lifeboat Foundation RE.WORK” by November 27.

Your message should be 100 words or less and should explain why it is important for you to attend. We have one ticket to give away.

Beyond the managerial challenges (downside risks) presented by the exponential technologies as it is understood in the Technological Singularity and its inherent futuristic forces impacting the present and the future now,   there are also some grave global risks that many forms of management have to tackle with immediately.

These grave global risks have nothing to do with advanced science or technology.    Many of these hazards stem from nature and some are,  as well,   man made.

For instance,   these grave global risks ─  embodying  the Disruptional Singularity ─  are geological, climatological, political, geopolitical, demographic, social, economic, financial, legal  and environmental,  among others.  The Disruptional Singularity’s major risks are gravely threatening us right now,  not later.

Read the full document at http://lnkd.in/bYP2nDC