БЛОГ

Archive for the ‘life extension’ category: Page 297

Nov 28, 2016

Linking Excess Fat Tissue, Immune Dysfunction, and Cellular Senescence in Aging

Posted by in category: life extension

Fat tissue, immune dysfunction and cellular senescence are closely related. Here we have some commentary from Reason at Fightaging! once of our new Patron sponsors about some recent research liking these factors together.

“Cellular senescence is one of the root causes of aging, and there are at present serious, well-funded efforts underway to produce rejuvenation therapies based on the selective destruction of senescent cells in old tissues. This progress is welcome, but it could have started a long time ago. It has taken many years of advocacy and the shoestring production of technology demonstrations to finally convince the broader community of scientists and funding institutions that the evidence has long merited serious investment in treatments to clear senescent cells”.

#sens #aging

Continue reading “Linking Excess Fat Tissue, Immune Dysfunction, and Cellular Senescence in Aging” »

Nov 27, 2016

A Semi-Automated Benchtop System to Produce Genetically Modified Stem Cells: Interview with Professor Jennifer Adair

Posted by in categories: biotech/medical, genetics, life extension, robotics/AI

New technology driving down the cost of research and therapies!


New technology arriving that will help drive down the costs of gene therapies.

“The researchers were able to use a closed, semi-automated benchtop system to produce genetically-modified HSCs in just one night and hope that such systems will increase the availability and affordability of cell therapies”.

Continue reading “A Semi-Automated Benchtop System to Produce Genetically Modified Stem Cells: Interview with Professor Jennifer Adair” »

Nov 26, 2016

New Technique Can Potentially Help Slow And Reverse An Important Cause Of Aging

Posted by in categories: biotech/medical, engineering, life extension

Led by Nikolay Kandul, senior postdoctoral scholar in biology and biological engineering in the laboratory of Professor of Biology Bruce Hay, the team developed a technique to remove mutated DNA from mitochondria, the small organelles that produce most of the chemical energy within a cell. A paper describing the research appears in the November 14 issue of Nature Communications. There are hundreds to thousands of mitochondria per cell, each of which carries its own small circular DNA genome, called mtDNA, the products of which are required for energy production. Because mtDNA has limited repair abilities, normal and mutant versions of mtDNA are often found in the same cell, a condition known as heteroplasmy.

Read more

Nov 26, 2016

Researchers put mouse embryos in suspended animation

Posted by in categories: biotech/medical, life extension

Hitting the pause button on development in embryos has implications for understanding aging.


UC San Francisco researchers have found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with potential implications for assisted reproduction, regenerative medicine, aging, and even cancer, the authors say.

The new study—published online November 23, 2016 in Nature —involved experiments with pre-implantation mouse embryos, called blastocysts. The researchers found that drugs that inhibit the activity a master regulator of called mTOR can put these early embryos into a stable and reversible state of suspended animation.

Continue reading “Researchers put mouse embryos in suspended animation” »

Nov 26, 2016

Scientists to ‘reset’ blood proteins in attempt to slow ageing process

Posted by in categories: biotech/medical, life extension

Progress towards making a blood scrubber to calibrate the pro aging factors in blood. Irina Conboy has spent the last 20 years working on parabiosis and signalling factors in blood and this is yet another step forward for their research.

Whilst many are seeking the secret sauce in young blood the data suggests it is much more likely the case that old blood contains too many pro-aging factors eg, TGF-beta, TNF-a, IL-6, CD38 etc… The aim is now to filter old blood and calibrate such factors in order to promote a pro-youthful signalling environment. If only this device was small enough to wear or implant.


In what could be a fresh chapter in the never-ending story of the search for eternal youth, scientists are to tinker with people’s blood in the hope of slowing down the ageing process and preventing age-related diseases.

Continue reading “Scientists to ‘reset’ blood proteins in attempt to slow ageing process” »

Nov 25, 2016

Life Extension Meetup

Posted by in category: life extension

29th November in Berlin there is a meetup for LE enthusiasts.


Announcing our year-end meetup in Berlin.

Join our casual get together of like-minded people. We chat about extending our healthy lifespans and the latest developments in this exciting field.

Continue reading “Life Extension Meetup” »

Nov 25, 2016

Some Adaptive Immune Cells Become More Innate-Like in the Aged Immune System

Posted by in categories: biotech/medical, life extension

Destroying and replacing the immune system is one of the approaches to treat the aging process.


Fightaging! provides some commentary about the immune system in relation to aging. Addressing the decline of the immune system is one of the approaches SRF is interested in and is a cornerstone of rejuvenation biotechnology.

“Understanding exactly how aging progressively harms the intricate choreography of the immune response is a massive project, and nowhere near completion. It is possible to judge how far along researchers are in this work by the side effect of the quality of therapies for autoimmune disease, which are malfunctions in immune configuration, and largely incurable at the present time. From a practical point of view, and as mentioned above, the best prospects for effective treatments in the near future involve destroying and recreating the immune system. That works around our comparative ignorance by removing all of the problems that researchers don’t understand in addition to ones that they do.”

Continue reading “Some Adaptive Immune Cells Become More Innate-Like in the Aged Immune System” »

Nov 25, 2016

The road is long but we can get there

Posted by in categories: biotech/medical, life extension

This gives a very simple summary of the process of drug development.


The development process from Pre-Clinical testing to an approved product we can use is a long one. A global average of 17 years with the US being 12 years is the historical norm for new drugs and therapies to be developed.

#aging #crowdfundthecure

Continue reading “The road is long but we can get there” »

Nov 24, 2016

Happy Thanksgiving from SENS Research :D

Posted by in categories: biotech/medical, life extension

Happy Thanksgiving! This year during your holiday meal, share what you are thankful for and think about how to pay it forward on #GivingTuesday.

We are working hard to treat age-related diseases so that we all get to enjoy more wonderful days together like this. We need your help to do it.

#sens

Continue reading “Happy Thanksgiving from SENS Research :D” »

Nov 24, 2016

Predicting the Order of Arrival of the First Rejuvenation Therapies

Posted by in categories: biotech/medical, life extension

Speculation about what order rejuvenation biotechnologies will arrive.


The first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision: that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repair that damage or render it irrelevant will as a result produce rejuvenation. Until very recently, no medical technology could achieve this goal, and few research groups were even aiming for that outcome. We are in the midst of a grand transition, however, in which the research and development community is finally turning its attention to the causes of aging, understanding that this is the only way to effectively treat and cure age-related disease. Age-related diseases are age-related precisely because they are caused by the same processes of damage that cause aging: the only distinctions between aging and disease are the names given to various collections of symptoms. All of frailty, disease, weakness, pain, and suffering in aging is the result of accumulated damage at the level of cells and protein machinery inside those cells. Once the medical community becomes firmly set on the goal of repairing that damage, we’ll be well on the way to controlling and managing aging as a chronic condition — preventing it from causing harm to the patient by periodically repairing and removing its causes before they rise to the level of producing symptoms and dysfunction. The therapies of the future will be very different from the therapies of the past.

The full rejuvenation toolkit of the next few decades will consist of a range of different treatments, each targeting a different type of molecular damage in cells and tissues. In this post, I’ll take a look at the likely order of arrival of some of these therapies, based on what is presently going on in research, funding, and for-profit development. This is an update to a similar post written four years ago, now become somewhat dated given recent advances in the field. Circumstances change, and considerable progress has been made in some lines of research and development.

Continue reading “Predicting the Order of Arrival of the First Rejuvenation Therapies” »