БЛОГ

Archive for the ‘life extension’ category: Page 353

Mar 29, 2019

After a warm welcome from Aubrey de Grey from SENS and myself on behalf of Forever Healthy and lot of exciting talks, day one of Undoing Aging 2019 ended with an entertaining debate when Vadim Gladyshev from Harvard and Aubrey discussed comprehensive damage repair

Posted by in category: life extension

Looking forward to today’s program!

UA 2019: fb.com/events/2044104465916196/

Read more

Mar 28, 2019

The Pursuit of Immortality, Regeneration & Longevity

Posted by in categories: biotech/medical, life extension

Join us at 7pm tonight!


Neal vanderee officiator at the church of perpetual life.

Continue reading “The Pursuit of Immortality, Regeneration & Longevity” »

Mar 28, 2019

SXSW: These two futurists want to freeze your body after death and replace your brain

Posted by in categories: biotech/medical, cryonics, cyborgs, life extension, neuroscience, transhumanism

You might think we’re not in Texas anymore but in some strange episode of Black Mirror, the Netflix series, says Nikos Acuna who is moderating this SXSW panel on transhumanism.

In fact you’d be forgiven if you did as there is talk about cryo-preserving the body after being declared dead, in the hopes you can be resurrected when the science is here to safely defrost your body and cure you of your ailments. There is also talk on mind uploading, and replacing parts of our brains with neural prosthetics. This all sounds like science-fiction but these days the stuff of science fiction has become fact.

Transhumanist technologies are about overcoming the limitations of human biology and Dr Max More and Dr Randal Koene are at the forefront of these technologies.

Continue reading “SXSW: These two futurists want to freeze your body after death and replace your brain” »

Mar 28, 2019

3 Reasons Why “Ending Suffering” Should Be the #1 Transhumanist Priority – Article

Posted by in categories: existential risks, geopolitics, life extension, neuroscience, transhumanism

BY HANK PELLISSIER


Hank Pellissier

Editor’s Note: The U.S. Transhumanist Party / Transhuman Party features this proposal by our member Hank Pellissier for a new website called Paradise2040, which will focus on the abolition of involuntary suffering and incremental ways of getting there within the next 21 years. This is an endeavor supported by Article IV of the Transhumanist Bill of Rights, Version 3.0. It is also a current within transhumanist thinking that, as Mr. Pellissier points out, could bring additional support to the movement. Different transhumanists will have different views as to what the most important aims of transhumanism should be. As an organization that embraces pluralism and diversity of thought, the U.S. Transhumanist Party / Transhuman Party would encourage any of our members who agree with the direction Mr. Pellissier proposes to collaborate with him on the creation of the Paradise2040 website.

~ Gennady Stolyarov II, Chairman, United States Transhumanist Party / Transhuman Party, March 25, 2019

Continue reading “3 Reasons Why ‘Ending Suffering’ Should Be the #1 Transhumanist Priority – Article” »

Mar 27, 2019

Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer’s disease

Posted by in categories: biotech/medical, life extension, neuroscience

https://paper.li/e-1437691924#/ https://www.nature.com/articles/s41591-019-0375-9


The hippocampus is one of the most affected areas in Alzheimer’s disease (AD). Moreover, this structure hosts one of the most unique phenomena of the adult mammalian brain, namely, the addition of new neurons throughout life. This process, called adult hippocampal neurogenesis (AHN), confers an unparalleled degree of plasticity to the entire hippocampal circuitry3,4. Nonetheless, direct evidence of AHN in humans has remained elusive. Thus, determining whether new neurons are continuously incorporated into the human dentate gyrus (DG) during physiological and pathological aging is a crucial question with outstanding therapeutic potential. By combining human brain samples obtained under tightly controlled conditions and state-of-the-art tissue processing methods, we identified thousands of immature neurons in the DG of neurologically healthy human subjects up to the ninth decade of life. These neurons exhibited variable degrees of maturation along differentiation stages of AHN. In sharp contrast, the number and maturation of these neurons progressively declined as AD advanced. These results demonstrate the persistence of AHN during both physiological and pathological aging in humans and provide evidence for impaired neurogenesis as a potentially relevant mechanism underlying memory deficits in AD that might be amenable to novel therapeutic strategies.

Read more

Mar 26, 2019

Chronic Inflammation Leads to Toxic NET Buildup

Posted by in categories: biotech/medical, life extension

A new review discusses how neutrophils release toxic substances into the body under inflammatory conditions, detailing one of the ways in which chronic inflammation causes long-term damage.

Casting a deadly NET

As we age, we suffer from the ever-increasing chronic inflammation known as inflammaging. This persistent, smoldering background of low-grade inflammation harms wound healing and promotes multiple age-related diseases. Senescent cells, a weakened immune system, and chronic infections are all proposed to contribute to inflammaging.

Continue reading “Chronic Inflammation Leads to Toxic NET Buildup” »

Mar 25, 2019

Senescent Cell Clearance Improves Intervertebral Disc Degeneration

Posted by in categories: biotech/medical, life extension

The presence of senescent cells has been implicated in a wide range of age-related diseases and even conditions such as T1 diabetes. Today, we want to draw your attention to a new publication that explores the relationship between senescent cells and intervertebral disc degeneration (IDD).

It was already known that senescent cells increase during the progression of IDD, but it was not known if they were a driver or a consequence of IDD.

Read more

Mar 22, 2019

CRISPR/Cas9 therapy can suppress aging, enhance health and extend life span in mice

Posted by in categories: biotech/medical, genetics, life extension

The findings, published on February 18, 2019 in the journal Nature Medicine, highlight a novel CRISPR/Cas9 genome-editing therapy that can suppress the accelerated aging observed in mice with Hutchinson-Gilford progeria syndrome, a rare genetic disorder that also afflicts humans. This treatment provides important insight into the molecular pathways involved in accelerated aging, as well as how to reduce toxic proteins via gene therapy.

“Aging is a complex process in which cells start to lose their functionality, so it is critical for us to find effective ways to study the molecular drivers of aging,” says Juan Carlos Izpisua Belmonte, a professor in Salk’s Gene Expression Laboratory and senior author of the paper. “Progeria is an ideal aging model because it allows us to devise an intervention, refine it and test it again quickly.”

With an early onset and fast progression, progeria is one of the most severe forms of a group of degenerative disorders caused by a mutation in the LMNA gene. Both mice and humans with progeria show many signs of aging, including DNA damage, cardiac dysfunction and dramatically shortened life span. The LMNA gene normally produces two similar proteins inside a cell: lamin A and lamin C. Progeria shifts the production of lamin A to progerin. Progerin is a shortened, toxic form of lamin A that accumulates with age and is exacerbated in those with progeria.

Read more

Mar 22, 2019

Dr. John LaMattina — Former President Pfizer Global R&D; Partner PureTech Ventures — IdeaXme — Ira Pastor

Posted by in categories: aging, bioengineering, biotech/medical, business, DNA, genetics, health, life extension, science, transhumanism

Mar 22, 2019

Ending Age-Related Diseases Conference: March Update

Posted by in categories: biotech/medical, business, life extension

On July 11-12th, we return to the Cooper Union in New York City for our second annual Ending Age-Related Diseases conference, which focuses on the progress in aging research as well as the business side of biotech.

We will be bringing you the latest aging research, investment, and business knowledge from some of the top experts in the industry. We will be packing two days full of talks and discussion panels featuring the people who are developing the technologies that could change the way we regard and treat aging forever.

We are currently offering reduced ticket prices until March 31st, after which the price increases to the regular $400 cost. If you would like to take advantage of this special offer, head on over to our event ticket page to secure your place now.

Continue reading “Ending Age-Related Diseases Conference: March Update” »