Dr. Antonei B. Csoka
Antonei
B. Csoka, Ph.D. is
Assistant Professor in the Department of Anatomy at Howard University
and a Member of the Alcor Scientific Advisory Board as well as the UK
Cryonics and Cryopreservation Research Network and Global Healthspan
Policy Institute. He was featured in the first Immortality Institute
film,
Exploring Life
Extension.
Antonei earned his B.S. in Genetics from the University of
Newcastle, U.K. in 1991, his M.S. in Molecular Pathology and Toxicology
from the University of Leicester, U.K. in 1993, and his Ph.D. in Cell
and Molecular Biology from the University of Debrecen, Hungary in 1998.
He performed postdoctoral research at the University of California, San
Francisco, where he cloned the human hyaluronidase genes, which are
involved in fertilization, embryonic development, and cancer. As a
postdoctoral research associate at Brown University from 2001 to 2003,
he was a key player in the identification of the gene that causes
Hutchinson-Gilford Progeria Syndrome (progeria), a disease with many
features of “accelerated aging”. It is hoped that the identification of
the gene for progeria will provide insights into the mechanisms of
normal aging.
Antonei coauthored
Genome-scale expression profiling of
Hutchinson—Gilford
progeria
syndrome reveals widespread
transcriptional misregulation leading to mesodermal/
mesenchymal defects and accelerated atherosclerosis,
Lamin A/C Expression Is a Marker of Mouse and Human Embryonic Stem
Cell
Differentiation,
Hyaluronidase reduces human breast cancer xenografts in SCID
mice, and
HYAL1LUCA-1, a candidate tumor suppressor gene on
chromosome
3p21.3, is
inactivated in head and neck squamous cell carcinomas by aberrant
splicing of pre-mRNA.
As an Assistant Professor at Howard University, Antonei is developing
animal models of progeria, studying the role of nuclear lamina
dysfunction in human aging, and investigating the potential of stem
cells, cellular reprogramming, and epigenetics for the treatment of
age-related diseases.
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