Dr. Thomas H. LaBean
The article DNA self-assembly used to mass-produce patterned nanostructures said
Duke University scientists have used the self-assembling properties of DNA to mass-produce nanometer-scale structures in the shape of a 4x4 grids, on which patterns of molecules can be specified. They said the achievement represents a step toward mass-producing electronic or optical circuits at a scale 10 times smaller than the smallest circuits now being manufactured.
Instead of using silicon as the platform for tiny circuits, as is done in the current manufacturing technique of photolithography, the Duke researchers used DNA strands to create grids less than one ten-millionth of a meter square. The smallest features on these square DNA lattices are approximately five to 10 billionths of a meter (nanometers), according to the scientists, compared with about 65 nanometers in silicon circuits created using photolithography.
“The process we’ve described creates lattices — with patterns we specify — at least tenfold smaller than the best lithography being used right now”, Thom LaBean said. “Plus, because we’re using DNA building blocks that assemble themselves, we can simultaneously make trillions of copies of a desired structure.”
Dr. Thomas H. LaBean received a B.S. with Honors in Biochemistry
from
Michigan State University in 1985 and a Ph.D. in Biochemistry from
University of Pennsylvania in 1993. He is currently engaged in molecular
engineering, self-assembly, and bionanoscience at the
Computer Science
Department at Duke University.
Thom is co-organizer of the NanoScience Seminar Series
at Duke
University from 2003 to the present, on the Clean Room Design Committee,
CEIMAS, at Duke University from 2003 to the present, on the Materials
Governance Committee at Duke University from 2001 to the present, on the
Editorial Board of the
Journal of Biomedical Nanotechnology, and been a
Reviewer for the
Journal of the American Chemical Society,
Proceeding of
the National Academy of Science (PNAS),
Langmuir,
Nanotechnology,
Nano
Letters,
Natural Computing, and
The Quarterly Review of Biology.
He coauthored Programmable DNA Self-assemblies for Nanoscale
Organization of Ligands and Proteins in Nano Letters,
Parallel Molecular Computation of Pair-wise XOR Using DNA “String Tile”
Self-Assembly in
Journal of the American Chemical Society,
Global
Similarities in
Nucleotide
Base Composition among Disparate Functional Classes of Single-Stranded
RNA Imply Evolutionary Convergence in RNA, and
Libraries of
Random-Sequence Polypeptides Produced with High Yield as Carboxy-Terminal
Fusions with Ubiquitin in
Molecular Diversity.
Thom holds two patents for
Methods and Materials for Producing Gene
Libraries. He was awarded the rank of Eagle Scout by the Boy Scouts of
America in 1979.