Dr. Darrell N. Kotton

Darrell N. Kotton, M.D. is Associate Professor of Medicine and Pathology and Director, Center for Regenerative Medicine (CReM) at Boston University School of Medicine. He also attends in the Medical Intensive Care Unit and on the Pulmonary Consultation Service at Boston Medical Center.
 
Darrell’s research focuses on stem cell biology and gene therapy related to lung injury and repair. He is an NIH-funded Principal Investigator and a member of several research groups at the Pulmonary Center: the Stem Cell Biology and Gene Therapy Group, the Epithelial Group, and the Developmental Biology Group. His laboratory currently utilizes several stem cell populations, including embryonic stem cells in order to develop novel stem cell-based therapies for lung disease. In addition, he specializes in the genetic manipulation of stem cells as well as resident lung cells using lentiviral vectors. Projects in his lab are currently focused on utilizing these novel vectors for the study of alpha-1 anti-trypsin deficiency, COPD, Cystic Fibrosis, and lung inflammatory pathways.
 
In 2009, Darrell Kotton and Gustavo Mostoslavsky became Co-Directors of a campus-wide research initiative, the Boston University Center for Regenerative Medicine (CReM), bringing together several research groups on campus focused on various aspects of stem cell biology and regenerative medicine.
 
Darrell coauthored Bone marrow-derived cells as progenitors of lung alveolar epithelium, Side population cells and Bcrp1 expression in lung, Failure of Bone Marrow to Reconstitute Lung Epithelium, Origin and phenotype of lung side population cells, Stem cell antigen-1 expression in the pulmonary vascular endothelium, A novel stem-cell population in adult liver with potent hematopoietic-reconstitution activity, and Exogenous control of mammalian gene expression via modulation of translational termination.
 
He earned his M.D. at Washington University School of Medicine, his Internship and Residency at University of Pennsylvania, his Fellowship at Boston University, and did his Post-Doctoral Research Fellowship at Harvard Medical School.
 
Read Human Induced Pluripotent Stem Cells Generated to Further Treatments for Lung Disease, Gene Therapy Makes Mice Breath Easier: Preventing Progression of Emphysema, and Converting Adult Somatic Cells To Pluripotent Stem Cells Using A Single Virus.