Dr. Darrell N. Kotton
Darrell
N. Kotton, M.D. is
Associate Professor of Medicine and Pathology and
Director, Center for Regenerative Medicine (CReM) at
Boston University School of Medicine.
He also attends in the Medical Intensive Care Unit and on the Pulmonary
Consultation Service at Boston Medical Center.
Darrell’s research focuses on stem cell biology and gene therapy
related to
lung
injury and repair. He is an NIH-funded Principal Investigator and a
member of several research groups at the Pulmonary Center: the Stem Cell
Biology and Gene Therapy Group, the Epithelial Group, and the
Developmental Biology Group. His laboratory currently utilizes
several stem cell populations, including embryonic stem cells in order
to develop novel stem cell-based therapies for lung disease. In
addition, he specializes in the genetic manipulation of stem
cells as well as resident lung cells using lentiviral vectors. Projects
in his lab are currently focused on utilizing these novel vectors for
the study of alpha-1 anti-trypsin deficiency, COPD, Cystic Fibrosis, and
lung inflammatory pathways.
In 2009, Darrell Kotton and Gustavo Mostoslavsky became Co-Directors of
a
campus-wide research initiative, the Boston University
Center for
Regenerative Medicine (CReM), bringing together several research
groups
on campus focused on various aspects of stem cell biology and
regenerative medicine.
Darrell coauthored
Bone marrow-derived cells as progenitors of lung alveolar
epithelium,
Side population cells and Bcrp1 expression in lung,
Failure of Bone Marrow to Reconstitute Lung Epithelium,
Origin and phenotype of lung side population cells,
Stem cell antigen-1 expression in the pulmonary vascular
endothelium,
A novel stem-cell population in adult liver with potent
hematopoietic-reconstitution activity, and
Exogenous control of mammalian gene expression
via modulation of translational termination.
He earned his M.D. at Washington University School of Medicine, his
Internship and Residency at University of Pennsylvania, his
Fellowship at Boston University,
and
did his Post-Doctoral Research Fellowship at
Harvard Medical School.
Read Human
Induced Pluripotent Stem Cells Generated to Further Treatments for
Lung Disease,
Gene Therapy Makes Mice Breath Easier: Preventing Progression of
Emphysema, and
Converting Adult Somatic Cells To Pluripotent Stem Cells Using A
Single
Virus.