Lifeboat Foundation

Harnessing rare genetic mutations could help end America’s opioid epidemic.

Although schizophrenia can be a very complex illness some new studies show that some major genetic factors could be the cause and then cured much easier through gene therapy.

Summary: Researchers leveraged cutting-edge technology to gain insights into schizophrenia’s neurodevelopmental origins. The researchers grew brain organoids from patients’ skin cells, finding persistent axonal disruptions in those with schizophrenia.

In another study, researchers zeroed in on a schizophrenia risk gene, CYFIP1, revealing its potential role in brain immune cells called microglia and their influence on synaptic pruning – a crucial process for brain health.

I found this on NewsBreak: Decoding the Mysteries of Life and the Cosmos: A Journey Through the Last Decade of Science.

By: Jason St Clair.

It’s worth reflecting on the scientific breakthroughs that have shaped our understanding of the universe and ourselves from 2010 to 2019. From the creation of synthetic life to the first glimpse of a black hole, these discoveries remind us of the indomitable human spirit and our unending quest for knowledge.

Continue reading “Decoding the Mysteries of Life and the Cosmos: A Journey Through the Last Decade of Science” »

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Epigenetic Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7xyIU-LSYLyQ…

Columbia neuroscientists have identified a genetic mutation that fends off Alzheimer’s in people at high risk and could lead to a new way to protect people from the disease.

If we can prove the concept of this technology in the two diseases we’re studying, we can then apply it to hundreds or thousands of diseases of the brain.

Yong-Hui Jiang, MD, PhD

Yes, please. Huntington disease hopefully.

Continue reading “Large NIH Grant Supports CRISPR-based Gene Therapy Development for Brain Diseases” »

A team of researchers has reported in Aging Cell that longer-lived Chinese women have less epigenetic noise in crucial areas of the genome. Order and disorder We have previously reported that the accumulation of epigenetic noise appears […].

For as long as superheroes have been imagined, there’s been a superhero who can regrow limbs. Other animals (like salamanders and sharks) do it, why couldn’t we? Scientists have also tackled this question because, obviously, humans don’t naturally regrow limbs. But before we move on to regrowing limbs ourselves, we need to understand how other species do it.

In a new study, researchers mapped the proteins that kick off limb creation in mice and chicks, finding that a cocktail of just three proteins performs the initial magic.

“People in the field have known a lot of the proteins critical for limb formation, but we found that there are proteins we missed,” said study co-first author ChangHee Lee, research fellow in genetics in the lab of Cliff Tabin at Harvard Medical School.

We depend on our cells being able to divide and multiply, whether it’s to replace sunburnt skin or replenish our blood supply and recover from injury. Chromosomes, which carry all of our genetic instructions, must be copied in a complete way during cell division. Telomeres, which cap the ends of chromosomes, play a critical role in this cell-renewal process—with a direct bearing on health and disease.