Lifeboat Foundation

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions.

Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types of microbes, including yeast and bacteria, and they showed that these formulations could withstand high temperatures, radiation, and industrial processing that can damage unprotected microbes.

In an even more extreme test, some of the microbes recently returned from a trip to the International Space Station, coordinated by Space Center Houston Manager of Science and Research Phyllis Friello, and the researchers are now analyzing how well the microbes were able to withstand those conditions.

Researchers have developed a novel 3D stretchable electronic strip which is expected to open up a range of new possibilities in wearable electronic textiles.

A team at Nottingham Trent University’s Medical Technologies Innovation Facility has led the work, which has paved the way for a new generation of electronic devices which could be embedded in clothing for possible use in health care and elite sports settings.

The research, which also involved industry partner Kymira Ltd, is published in Scientific Reports.

A compact, lightweight sensor system with infrared imaging capabilities developed by an international team of engineers could be easily fitted to a drone for remote crop monitoring.

This flat-optics technology has the potential to replace traditional optical lens applications for environmental sensing in a range of industries.

This innovation could result in cheaper groceries as farmers would be able to pinpoint which crops require irrigation, fertilization and pest control, instead of taking a one-size-fits-all approach, thereby potentially boosting their harvests.

The four volunteers who have been living and working inside NASA’s first simulated yearlong Mars habitat mission are set to exit their ground-based home on Saturday, July 6. NASA will provide live coverage of the crew’s exit from the habitat at NASA’s Johnson Space Center in Houston at 5 p.m. EDT.

NASA will stream the activity, which will include a short welcome ceremony, on NASA+, NASA Television, the NASA app, the agency’s website, and NASA Johnson’s X and Facebook accounts. Learn how to stream NASA TV through a variety of platforms, including social media.

The first Crew Health and Performance Exploration Analog (CHAPEA) mission began in the 3D printed habitat on June 25, 2023, with crew members Kelly Haston, Anca Selariu, Ross Brockwell, and Nathan Jones. For more than a year, the crew simulated Mars mission operations, including “Marswalks,” grew and harvested several vegetables to supplement their shelf-stable food, maintained their equipment and habitat, and operated under additional stressors a Mars crew will experience, including communication delays with Earth, resource limitations, and isolation.

This study uncoversthe pivotal role of the enzyme METTL4 in promoting tumor metastasis through the mediation of nuclear N6-methyldeoxyadenosine (6mA) in mammalian cells. By utilizing cellular models, the study demonstrates how hypoxia induces METTL4 to mediate 6mA modifications. This process, in turn, activates genes essential for tumor metastasis, including the involvement of specific long noncoding RNA and a novel HIF-1α co-activator, ZMIZ1. These findings not only shed light on the epigenetic mechanisms driving tumor progression but also establish METTL4 as a prognostic marker for cancer and a potential target for therapeutic intervention. The promise of this discovery lies in its potential to inspire new strategies for combating hypoxia-induced tumor progression, opening avenues for further research and development in cancer treatment.

DNA N6-methyldeoxyadenosine (6mA) has been recognized in various organisms for its role in gene regulation. However, its function in mammalian cells, particularly in the context of cancer, has remained elusive. Previous studies have shown that 6mA modifications can influence gene expression and are present in several species, indicating a potential regulatory role in tumorigenesis. This research addresses a critical gap in understanding the nuclear role of 6mA and its enzymatic mediator METTL4, in mammalian tumor cells, particularly under hypoxia (a common condition in tumor microenvironments that promotes metastasis). The study posits that METTL4-mediated 6mA deposition is a key epigenetic modification that activates metastasis-inducing genes. This finding offers a new perspective on the mechanisms of tumor progression and identifying novel targets for therapeutic intervention.

Continue reading “The Enzyme Leading the Charge Against Tumor metastasis” »

Scientists at Duke-NUS Medical School have identified how the first domino falls after a person encounters an allergen, such as peanuts, shellfish, pollen or dustmites. Their discovery, published in the April issue of Nature Immunology, could herald the development of drugs to prevent these severe reactions.

It is well established that when mast cells, a type of immune cell, mistake a harmless substance, such as peanuts or dust mites, as a threat, they release an immediate first wave of bioactive chemicals against the perceived threat. When mast cells, which reside under the skin, around blood vessels and in the linings of the airways and the gastrointestinal tract, simultaneously release their pre-stored load of bioactive chemicals into the blood, instant and systemic shock can result, which can be lethal without quick intervention.

More than 10 per cent of the global population suffers from food allergies, according to the World Health Organisation (WHO). As allergy rates continue to climb, so does the incidence of food-triggered anaphylaxis and asthma worldwide. In Singapore, asthma affects one in five children while food allergies are already the leading cause of anaphylactic shock.

A UCLA Health study explored the traits of resilient individuals, discovering significant neural activities in the brain regions for cognition and emotional regulation, and healthy gut microbiome activities.

The research highlighted differences in microbiome metabolites and gene activity, indicating lower inflammation and better gut health in resilient people compared to less resilient individuals. This comprehensive approach may lead to interventions that enhance resilience to stress, possibly preventing various health issues.

Resilience and Health.

What You Should Know:

– A glimmer of hope emerged today for rectal cancer patients as a collaborative effort between Case Western Reserve University (CWRU), Cleveland Clinic, and University Hospitals (UH) received a $2.78 million grant over five years from the National Institutes of Health and National Cancer Institute. This grant will fuel research leveraging artificial intelligence (AI) to personalize treatment for rectal cancer patients.

– The new research effort signifies a significant step forward in the fight against rectal cancer. By harnessing the power of AI, researchers are on the path to developing more precise treatment strategies, ultimately improving patient outcomes and quality of life.

Robots with human skin.

In a breakthrough that isn’t at all creepy, scientists have devised a method of anchoring living human skin to robots’ faces. The technology could actually have some valuable applications, beyond making Westworld-like scenarios a reality.

Two years ago, Prof. Shoji Takeuchi and colleagues at the University of Tokyo successfully covered a motorized robotic finger with a bioengineered skin made from live human cells.

Continue reading “New technique gives robotic faces living human skin” »