Dec 24, 2015

New genes associated with extreme longevity identified

Posted by in categories: biotech/medical, genetics, health, life extension, mathematics, neuroscience

Death is a disease.

Diseases can and will be cured.

Do the math. wink

Disease GWAS show substantial genetic overlap with longevity. Shown are results for coronary artery disease and Alzheimer’s disease. The y axis is the observed P values for longevity, and the x axis is the expected P values under the null hypothesis that the disease is independent of longevity. The cyan, blue and purple lines show the P values for longevity of the top 100, 250, and 500 disease SNPs from independent genetic loci, respectively. Red lines show the background distribution of longevity P values for all independent genetic loci tested in both the longevity and disease GWAS. The grey horizontal line corresponds to the threshold for nominal significance (P = 0.05) for longevity. Significance of enrichment was determined with the hypergeometric test. (credit: Kristen Fortney et al./PLOS Genetics)

What’s the secret of centenarians who have health and diet habits similar to the average person but have remained active and alert at very old ages?

Genes. That’s according to scientists at Stanford University and the University of Bologna, who have written a new report published in PLOS Genetics, based on their finding of several disease variants that may be absent in centenarians compared to the general population.

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