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How the distinctive folds in the brain cortex, seen in humans, whales, other animals, form

One of the defining features of humans is our brain’s remarkable capacity for language, planning, memory, creativity, and more. These abilities stem not just from our large brain size, but also from the folded structure of the brain’s outer layer, the cerebral cortex.

A new study, published in the journal Nature Communications, offers insight into how these wrinkles form, pointing to a range of contributing factors—including the number of early-stage , how they migrate during development, and the specific types of cells involved.

These findings may help guide future research into brain development, evolution, and health.

Epitranscriptomic Regulation of Hepatitis B Virus by RNA 5-Methylcytosine: Functions, Mechanisms, and Therapeutic Potential

Hepatitis B virus (HBV) remains a major global health challenge, with over 296 million people chronically infected worldwide. Despite the availability of antiviral therapies, a functional cure is rarely achieved, highlighting the need for novel therapeutic strategies. RNA 5-methylcytosine (m5C) is a pivotal epitranscriptomic mark implicated in RNA stability, transport, and translation. Emerging evidence shows that m5C is conserved within HBV RNA and plays critical roles in the viral life cycle. This review provides a comprehensive overview of the molecular mechanisms governing m5C deposition and recognition, summarizes recent advances in m5C biology, and highlights the emerging role of epitranscriptomic m5C regulation in HBV infection.

Bone and Brain Research Fine-Tuning Long-Term Astronaut Health

Bone and brain research wrapped up the week aboard the International Space Station on Friday helping doctors keep astronauts healthy when living in weightlessness. The Expedition 73 crew also checked out spacesuit gear, conducted ultrasound eye scans, and photographed Earth landmarks.

Harnessing mechanobiology to combat kidney disease

Chronic kidney disease affects an estimated 37 million people in the U.S., and for many, there is no cure. But a new research project at Washington University in St. Louis seeks to change that by uncovering the mechanical basis of kidney cell injury.

To tackle chronic kidney disease, Guy Genin, the Harold and Kathleen Faught Professor of Mechanical Engineering at the WashU McKelvey School of Engineering, and Jeffrey Miner, the Eduardo and Judith Slatopolsky Professor of Medicine in Nephrology at WashU Medicine, teamed up with Hani Suleiman, an assistant professor of medicine at the University of Texas Southwestern Medical Center. The interdisciplinary team, with expertise spanning medicine, cell biology, genetics and engineering, received a five-year $4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health (NIH).

With the NIH’s support, the team plans to study the mechanobiology of podocytes, specialized cells in the kidney that help filter blood.


Researchers at Washington University in St. Louis have received a $4 million grant to study specialized cells that could help treat kidney disease.

Maternal exposure to crude oil and flame retardants can affect later generations

A tiny fish with transparent embryos is helping University of California, Davis, researchers shed light on how exposure to crude oil and flame retardants can affect behavior, skeletal growth, cardiac health and other internal functions in offspring and subsequent generations.

The research on multiple generations of Atlantic killifish (mummichogs) was published across three papers in the journal Environmental Science & Technology.

The work, some dating back to the 2010 Deepwater Horizon oil spill off the Gulf coast, offers insight into how toxic exposures—even short ones—can unfold over time in many species.

Can immune cells stave off devastating neurodegenerative diseases? Scientists aim to find out

An evolving form of therapy to treat devastating neurodegenerative disorders by injecting fresh immune cells—microglia—directly into the brain, promises a new lease on health by slowing the progression of mind-robbing conditions.

The research, underway in China, is in the pre-clinical phase of investigation and is aimed at protecting vital neurons, while at the same time, combating the early hallmarks of neurological disorders, such as Alzheimer’s disease.

So far, the transplants have been performed in animal models, but they have ameliorated symptoms of neurological disease.

Wearable sweat sensor can detect responses to physical, emotional and pharmacological stress

Most people are well aware of the effects of chronic stress in the modern world. While some stress can be a good thing, like the type of stress your body feels during an intense workout, prolonged or chronic stress can lead to a myriad of health problems, including anxiety, heart disease, and inflammation. And, at a larger scale, the high prevalence of chronic stress in the population increases the burden on public health systems.

Tracking stress responses could help people better understand and manage stress, but stress can be difficult to measure and monitor in an objective and precise manner. Stress hormones fluctuate throughout the day, but current stress assessment methods rely on subjective self-reports, heart rate, or wearable sensors that only measure cortisol in a non-continuous manner. It is difficult to get a full picture of a person’s and its long-term effects with these current methods.

However, scientists have recently developed a device called the “Stressomic,” a wearable biosensor that can continuously monitor cortisol, epinephrine, and norepinephrine in sweat—which might just pave the way for better stress management. The device was recently tested in a study published in Science Advances. They claim that it’s capable of distinguishing between acute and and can be worn as a simple biocompatible patch placed on the skin.

Your Eye Movements Could Be Hiding Signs of a Failing Memory

The ways our eyes explore the world change subtly over time, affected by age and illness.

A new study now suggests some of those changes could be used to identify problems with memory and cognition.

Researchers from Canada and the West Indies built on previous work by searching for variations in eye viewing patterns in people with and without a diagnosis for a brain health issue.

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