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Dr. Fred Grossman — Coya Therapeutics — Multi-Modality Treg Therapies For Neurodegenerative Diseases

Multi-Modality Treg Therapies For Neurodegenerative Diseases — Dr. Fred Grossman, D.O., FAPA — President and Chief Medical Officer — Coya Therapeutics, Inc.

Dr. Fred Grossman, D.O., FAPA is President and Chief Medical Officer of Coya Therapeutics (https://coyatherapeutics.com/), a clinical-stage company focused on developing multi-modality, Regulatory T Cell (Treg) therapies for neurodegenerative diseases. Coya has already developed strong proof of concept data in Amyotrophic Lateral Sclerosis (ALS) and Alzheimer’s, and is also active in the autoimmune and metabolic disease domains.

Dr. Grossman brings over 20 years of drug development expertise having held senior executive leadership positions in large and small pharmaceutical companies, leading the development and FDA approval of numerous multi-billion dollar blockbuster drugs addressing significant unmet medical needs particularly across CNS disorders. He has close relationships with thought leaders worldwide and has negotiated directly with the FDA and Global Health Authorities for approval of many drugs across therapeutic areas.

Dr. Grossman held executive positions at Eli Lilly, Johnson & Johnson, Bristol Myers Squibb, and Sunovion. He served as President and Chief Medical Officer at Glenmark Pharmaceuticals, a $1.5 Billion per annum global pharmaceutical company based in India, overseeing development of an entire pipeline including generics, complex generics including 505(b) candidates, and next-generation biologics (including bi-specific antibodies).

Dr. Grossman also previously served as Chief Medical Officer at Mesoblast, Inc., developing allogeneic cellular therapies for inflammatory diseases.

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Marijuana Use Surpasses Cigarette Smoking

Rising cannabis use and falling smoking rates suggest legalization drives substitution of cannabis for cigarettes.

How does cannabis use influence cigarette smoking? This is what a recent study published in Addictive Behaviors hopes to address as a team of researchers investigated how recreational cannabis legalization has caused shifts in social dynamics, specifically regarding cigarette use. This study has the potential to help researcher better understand the social impacts of recreational cannabis legalization and the steps that can be taken to mitigate the negative impacts.

For the study, the researchers analyzed data obtained from the National Survey on Drug Use and Health for 30-day trends regarding cannabis-only use, cigarette-only use, and co-use for individuals 18 years and older and from time periods of 2015–2019, 2020, and 2021–2023. The goal of the study was to draw a connection between cannabis legalization and cigarette use, or co-use. In the end, the researchers found increases in cannabis-only use in 2015–2019, 2020, and 2021–2023 at 3.9% to 6.5%, 7.1%, and 7.9% to 10.6%, respectively. In contrast, cigarette-only use decreased during these same time periods at 15% to 12%, 10.3%, and 10.8% to 8.8%, respectively. Finally, the researchers observed consistent co-use during all three periods.

“The rising cannabis-only use across groups parallels the expanding state-level recreational cannabis legalization, increasing accessibility and normalization,” the study notes. “Conversely, continued declines in cigarette-only use align with decades of tobacco control efforts and evolving norms surrounding smoking. The relatively stable co-use trends may reflect substitution dynamics whereby some individuals replace cigarettes with cannabis, preventing co-use from rising in tandem with cannabis-only use.”

Spaceflight study reveals men experience greater eye changes, while brain differences between sexes are subtle

A new study into how spaceflight impacts the human brain and eyes revealed notable sex differences in brain fluid shifts, with female astronauts showing a greater reduction in fluid around the uppermost part of the brain than their male counterparts.

Led by Rachael D. Seidler, Ph.D., director of the University of Florida’s Astraeus Space Institute and professor of applied physiology and kinesiology, the study analyzed data from astronauts to determine how factors such as sex, age and body metrics relate to structural and eye changes after .

The findings, published in npj Microgravity, provide key information for protecting astronaut health on long-duration missions to the moon and Mars.

Sensory expectations configure neural responses before disturbances occur, study reveals

A study led by Jonathan Michaels, a Faculty of Health professor at York’s School of Kinesiology and Health Science, reveals how the brains of humans and monkeys use sensory expectations to prepare for unexpected disturbances, enabling faster and more accurate motor responses.

Published today in Nature, the study demonstrates that motor circuits across the brain do not passively wait for sensory signals. Instead, they proactively anticipate potential challenges, configuring themselves to respond effectively to disturbances. The research represents a significant leap forward in uncovering the brain’s predictive capabilities and its role in .

This advancement provides a clearer picture of the neural mechanisms underlying movement preparation and response, illustrating how expectation itself enhances precision and stability. The discovery opens new pathways for improving rehabilitation techniques and advancing brain-computer interface technology.

Why Some 80-Year-Olds Have the Memory of 50-Year-Olds

For 25 years, scientists have studied “SuperAgers”—people aged 80 and above whose memory rivals those decades younger. Research reveals that their brains either resist Alzheimer’s-related plaques and tangles or remain resilient despite having them.

These individuals maintain a youthful brain structure, with a thicker cortex and unique neurons linked to memory and social skills. Insights from their biology and behavior could inspire new strategies to protect cognitive health into late life.

For the past 25 years, researchers at Northwestern Medicine have been examining people aged 80 and older, known as “SuperAgers,” to uncover why their minds stay so sharp.

Skin-inspired organic biosensors can reliably track health-related signals in real-time

The rapid advancement of sensing and artificial intelligence (AI) systems has paved the way for the introduction of increasingly sophisticated wearable devices, such as fitness trackers and technologies that closely monitor signals associated with specific diseases or medical conditions. Many of these wearable electronics rely on so-called biosensors, devices that can convert biological responses into measurable electrical signals in real-time.

While and other are now widely used, the signals that many existing devices pick up are sometimes inaccurate or distorted. This is because the bending of sensors, moisture and temperature fluctuations sometimes produce inaccurate readings and drifts (i.e., gradual changes that are unrelated to a measured signal).

Researchers at Stanford University have developed new skin-inspired biosensors based on organic field effect transistors (OFETs), devices based on organic semiconductors that control the flow of current in electronics.

Merck Videos

Strategic Investments To Improve Patients’ Lives — Joel Krikston — Managing Director Venture Investments, [#Merck](https://www.facebook.com/watch/hashtag/merck?__eep__=6%2F&__cft__[0]=AZWHa0kseUKzVNcB3y0qk8cwqKXrjPP9UHHhebflI6mZJnviQw17L_42P2gl-qGy_e2nvTkuEHEy3wU-ru0SkJ7BqaUNULXHPS8QJnyFad71Ur_o9bODPNd_7Qk9jcnY_ftbVN0gZHTGyveR05k3WGcA8J2Vm_cyhkoo0w0kkbPi0qgSkNThFHMOi_ERtUgFhJqdO4otO9uKSoxgc4Joq0xf&__tn__=*NK-R) Global Health Innovation Fund / Co-Founder, [#MSD](https://www.facebook.com/watch/hashtag/msd?__eep__=6%2F&__cft__[0]=AZWHa0kseUKzVNcB3y0qk8cwqKXrjPP9UHHhebflI6mZJnviQw17L_42P2gl-qGy_e2nvTkuEHEy3wU-ru0SkJ7BqaUNULXHPS8QJnyFad71Ur_o9bODPNd_7Qk9jcnY_ftbVN0gZHTGyveR05k3WGcA8J2Vm_cyhkoo0w0kkbPi0qgSkNThFHMOi_ERtUgFhJqdO4otO9uKSoxgc4Joq0xf&__tn__=*NK-R) Idea Studios, joins me on Progress, Potential, And Possibilities.

Merck | 22K people are posting about this.

Chemists discover antibiotic for drug-resistant bacteria ‘hiding in plain sight’

Chemists from the University of Warwick and Monash University have discovered a promising new antibiotic that shows activity against drug-resistant bacterial pathogens, including MRSA and VRE

Antimicrobial resistance (AMR) is one of the world’s most urgent health challenges, with the WHO’s new report showing there are ‘too few antibacterials in the pipeline. Most of the ‘low-hanging fruit’ has already been found, and the limited commercial incentives deter investment in antibiotic discovery.

In a study published in the Journal of the American Chemical Society, researchers from the Monash Warwick Alliance Combating Emerging Superbug Threats Initiative have discovered a promising new antibiotic—pre-methylenomycin C lactone.

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