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Category: life extension

Breakdown and repair of metabolism in the aging brain

Age-related neurodegenerative disorders, including dementia, are a major global health concern. This article describes the first comprehensive, data-driven molecular model of the neuro-glia-vascular system to explore the complex relationships between the aging brain, energy metabolism, blood flow, and neuronal activity. Comprising 16,800 interaction pathways, the model includes all key enzymes, transporters, metabolites, and circulatory factors vital for neuronal electrical activity. We found significant alterations in metabolite concentrations and differential effects on adenosine triphosphate (ATP) supply in neurons and astrocytes and within subcellular compartments in aged brains and identified reduced sodium/potassium adenosine triphosphatase (Na+/K+-ATPase) activity as the leading cause of impaired neuronal action potentials.

DiGem- Digital Twin

🧬 What if every human had their own Digital Twin?

Not in 100 years.

Not in science fiction.

But within our lifetime.

For the past months, I’ve been building DiGem — a project focused on creating a Human Digital Twin: a digital representation of a person that combines health data, AI, lifestyle habits, and gamification into one system.

Imagine:

⚡ Your body displayed as a dashboard 🧠 AI acting as your personal health coach 📈 Real-time monitoring of your health and performance 🎼 Improving yourself through levels, XP, and achievements 🧬 A digital twin that evolves together with you.

Continue reading “DiGem- Digital Twin” | >

HDL Was 28, Now It’s Optimal: How I Did It

Join us on Patreon! / michaellustgartenphd.

Discount Links/Affiliates:
Blood testing (where I get the majority of my labs, for those who blood test with Quest): https://www.ultalabtests.com/partners
 those who blood test with LabCorp: https://www.anrdoezrs.net/click-10161
 At-Home Metabolomics: https://www.iollo.com?ref=michael-lus
 Use Code: CONQUERAGING At Checkout Clearly Filtered Water Filter: https://get.aspr.app/SHoPY Epigenetic, Telomere Testing: https://trudiagnostic.com/?irclickid=
 Use Code: CONQUERAGING NAD+ Quantification: https://www.jinfiniti.com/intracellul
 Use Code: ConquerAging At Checkout Oral Microbiome: https://www.bristlehealth.com/?ref=mi
 Enter Code: ConquerAging SiphoxHealth Blood Testing (ApoB, GrimAge): https://siphoxhealth.com/mlustgarten Green Tea: https://www.ochaandco.com/?ref=fqbtflod Use Code: ML10OFF Diet Tracking: https://shareasale.com/r.cfm?b=139013
 If you’d like to support the channel, you can do that with the website, Buy Me A Coffee: https://www.buymeacoffee.com/mlhnrca Conquer Aging Or Die Trying Merch! https://my-store-d4e7df.creator-sprin


Blood Testing Essentials (Biological Age, CVD-Risk, Kidney Health and Function):
PhenoAge (Biological Age): https://www.ultalabtests.com/partners


Measure the Bortz biological clock biomarkers: https://www.ultalabtests.com/partners


Calculate your biological age using the Bortz clock: https://www.longevity-tools.com/human


Transhumanist Anders Sandberg: Embrace Strangeness

“That which does not kill us only makes us stranger.”

14 years ago, I sat down with Dr. Anders Sandberg, computational neuroscientist and research fellow at Oxford’s Future of Humanity Institute, for his second appearance on my podcast. His twist on Nietzsche has stayed with me ever since.

This was 2012. Before ChatGPT, before CRISPR babies, before Neuralink implants in human skulls. And yet listen to what we covered:

The ethics of transhumanism and the limits of being human The Epic of Gilgamesh and humanity’s oldest obsession: immortality Enhancement arms-races and the risk of conflict between transhumanists and neo-luddites Hive-minds, distributed intelligence, and whether the Borg should scare us Mind uploading and what survives when the body doesn’t.

What strikes me now, rewatching it, is how little the fundamental questions have changed. The technology raced ahead. The philosophy is still catching up.

Anders argued that embracing strangeness is not a bug of the human future; it’s the feature. The question was never whether we would change. It’s whether we will change wisely.

Continue reading “Transhumanist Anders Sandberg: Embrace Strangeness” | >

Forcing cancer cells to die can alert the immune system to enhance anti-tumor attack

Unlike accidental cell death, some cells can actively decide to die through a controlled process. This is called programmed cell death and can occur in different forms, including apoptosis and necroptosis. Cells use this process when they are damaged, stressed, becoming cancerous, or infected by harmful microbes. This self-destruction mechanism helps to protect the body, but it is also involved in many diseases, such as infections, inflammatory conditions and cancer.

A major problem in cancer is that some tumors and cancer cells learn how to avoid apoptosis, allowing them to survive when they should die. This resistance can make cancer treatments less effective, especially in advanced or spreading (metastatic) cancers.

A research team led by Prof. Dr. Sjoerd van Wijk, Professor for Cell Biology at the Institute for Physiology and Cell Biology of the University of Veterinary Medicine (TiHo), and Dr. Francesco Pampaloni of the Goethe University Frankfurt, have studied a type of programmed cell death called necroptosis in advanced breast cancer. The scientists used patient-derived organoids, which are tiny 3D mini-tumors grown in the lab from real patients’ cancer cells. These mini tumors closely resemble the original cancer, making them useful for testing treatments and cell biology experiments.

Why Living Past 115 Is Almost Impossible | The Limit

Today, more people are living past 100 than ever before — even though the maximum human lifespan hasn’t moved past 115 years. But is that about to change?

The Limit host Daniel T. Allen spent months talking to medical researchers, biohackers, and centenarians. He also went through a battery of tests worth over $12,000 at a longevity clinic to find out how long he might live.

In this episode, Business Insider looked into what could radically extend human lifespan, including FDA-approved drugs, cellular reprogramming, and Bryan Johnson’s $2 million \.

Ultrasound-based approach may reduce harmful inflammation and support joint healing

As an aging population experiences joint pain and inflammation at an all-time high, researchers at The University of Alabama in Huntsville (UAH), a part of The University of Alabama System, have published new findings suggesting continuous low-intensity ultrasound may help shift the body’s immune response from prolonged inflammation toward tissue repair, a discovery that could eventually contribute to novel treatments for joint injuries and post-traumatic osteoarthritis.

The study, published in Scientific Reports, was conducted by a multidisciplinary team of UAH researchers under the leadership of Dr. Anuradha Subramanian, a professor of chemical and materials engineering.

The work brought together biological experimentation conducted by Dr. Shahid Khan as part of his doctoral work with computational and statistical methods developed by Dr. Satyaki Roy, a professor of mathematical sciences, along with additional contributions from graduate student Owen Trippany.

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