Most known for its role in movement, the cerebellum could compensate for flagging mental functions elsewhere in the brain.
Category: life extension
Mind May Be Older Than the Brain | Michael Levin on Life and Intelligence
Michael Levin is a developmental and synthetic biologist at Tufts University whose work sits at the intersection of biology, bioelectricity, artificial life, regenerative medicine, synthetic biology, computer science, cognitive science, and philosophy of mind. He is known for his research on how cells communicate, make decisions, build bodies, repair tissues, and form collective intelligence through bioelectric signals. His work on Xenobots and Anthrobots has opened new questions about living robots, synthetic life forms, biological machines, morphogenesis, basal cognition, cellular intelligence, regeneration, cancer, aging, and the nature of mind beyond the brain.
In this conversation, Michael Levin and I explore whether mind and intelligence are binary or exist on a continuum, why cognition may be much older than brains, and how systems from cells to humans can pursue goals in different ways. We discuss the TAME framework, the spectrum of persuadability, cognitive light cones, bioelectricity, gap junctions, multicellular intelligence, Xenobots, Anthrobots, kinematic self-replication, neural wound healing, emergence, physicalism, mathematics, Platonic space, algorithms, bubble sort, Turing machines, evolution, human creativity, artificial intelligence, regenerative medicine, and the future of biology. This episode is for anyone interested in philosophy, consciousness, mind, intelligence, synthetic biology, developmental biology, AI, complex systems, evolution, and the deeper question of what it means for matter to become alive, intelligent, or aware.
If you enjoyed the episode, please consider leaving a like, subscribing, and leaving a review on Youtube, Spotify and Apple. #philosophy #science.
Michael’s website: https://drmichaellevin.org/
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/ masud.gaziyev Support the work: https://buymeacoffee.com/philosophy.e… Get new episodes, guest announcements, reading notes, and ideas worth thinking about. Subscribe here: https://philosophyeveryday.beehiiv.com/ Chapters: 00:00 Mind Beyond the Brain 01:19 Is Mind Older Than the Brain? 04:06 Why Intelligence Is Not All-or-Nothing 06:58 How to Interact With Different Kinds of Minds 09:54 From Single Cells to Collective Intelligence 13:17 How Cells Build Bigger Goals 16:05 Life Recreated — Xenobots and Anthrobots 18:54 Where Do New Behaviours Come From? 21:57 Synthetic Life and the Limits of Evolution 35:01 What Happens When Biology Is Freed? 43:00 Why Biology Eventually Leads to Mathematics 46:07 Is “Emergence” Just a Fancy Word for Surprise? 53:11 Platonic Space: A Strange New Map of Reality 01:03:21 What We Received from Platonic Space 01:11:24 Human Evolution, Technology, and the Patterns Behind Progress 01:16:43 Regeneration, Cancer, and Aging.
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Ralph Merkle on Inverted-Mode Scanning Tunneling Microscopy
Plus cryptography & cryonics, information theoretic death, and obstacles to acceptance of biostasis
Jumping the clock: Engineering ageing in biomedicine
Engineering the age(ing) of tissues in vitro could lead to more representative and predictive models for the ageing population. This forum introduces methodological approaches for ‘age engineering’ (‘ageneering’) and further discusses future applications of age-matched cells, matrices, and microtissues in predictive disease modelling, biomarker discovery, and age-specific pharmacotoxicology.
A renewable cell source for cancer immunotherapy could make off-the-shelf treatments possible
In a paper published in Cell, a USC Stem Cell-led team reports a new way of generating a renewable and expandable supply of the progenitor cells that give rise to macrophages. These immune cells help drive the body’s response against pathogens, and they hold strong promise as the basis for immunotherapies against cancer and other diseases.
The paper, “Expansion and CAR Engineering of Granulocyte-Monocyte Progenitors for Cellular Immunotherapy,” demonstrates that progenitor cells known as granulocyte-monocyte progenitors (GMPs), which give rise to macrophages and other immune cells, can be extensively expanded in the laboratory and engineered both to target specific cancer markers and to help stimulate broader immune responses.
“The study establishes a scalable and engineerable GMP platform for cellular immunotherapy and introduces concepts that we believe could have broad implications for both cancer immunotherapy and stem cell biology,” said the paper’s corresponding author Qi-Long Ying, MD, Ph.D., professor of stem cell biology and regenerative medicine at the Keck School of Medicine of USC.
Life Summit — Tomorrow.bio
Many people want to live longer than what is currently possible, but medical technology is not progressing fast enough. At Tomorrow Biostasis, we use the latest cryopreservation technology to medically preserve and protect you for as long as it is needed. When medical technology has solved the life extension and aging problems, you will be reanimated to enjoy an extended life.
On the YouTube channel of Tomorrow Biostasis you can find more information about the concepts of cryopreservation, cryonics, biostasis, vitrification, human revival, and more. We also provide you with practical information about signing up with Tomorrow Biostasis. Get ready to get an insight into the fascinating world of cryopreservation!
Visit our website at: https://bit.ly/35KsOIq Sign up for Biostasis: https://bit.ly/3hGb6sq Schedule a free Consultation: https://bit.ly/3IIwkll.
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#TomorrowBiostasis #Cryopreservation #Cryonics.
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FOXO3: The Longevity Switch Inside Our Cells — Decoding the Master Regulator of Aging, Stress, and Disease
Aging is a universal biological process, yet the reasons why some individuals live significantly longer and healthier lives have long puzzled scientists. Among the genes linked to exceptional longevity, FOXO3 consistently stands out as one of the most influential “master controllers” of cellular resilience. This single transcription factor integrates signals from stress, metabolism, DNA repair, and stem cell biology, orchestrating a vast genetic program that determines how cells survive, adapt, or age [1].
In recent years, interest in FOXO3 has surged across aging research, regenerative medicine, oncology, and precision therapeutics. Variants of the FOXO3 gene are strongly associated with centenarian populations worldwide, while disruptions in its regulatory network contribute to multiple disorders, including cancer, neurodegeneration, metabolic decline, and tissue degeneration. With advances in computational biology and pathway analysis, it is now possible to map FOXO3’s complex signaling network and uncover new therapeutic strategies.
This blog post explores FOXO3’s multifaceted biological roles, its influence on disease, and what our curated data from TRANSFAC®, TRANSPATH®, and HumanPSD™ reveals about the FOXO3 regulatory network. The goal is to provide a scientifically rich yet accessible overview that sparks curiosity among researchers studying aging, longevity, and systems-level biology.