Researchers developed a high-resolution spatial proteomics method to map protein and sugar changes in the brain. The study identified molecular signatures that distinguish healthy aging from Alzheimer’s and Lewy body disease.
Category: life extension
Study suggests one common amino acid may affect how long men live
A large new study suggests that higher levels of a common amino acid called tyrosine may be linked to a shorter lifespan in men.
The research, published recently in the journal Aging, examined whether blood levels of two amino acids, phenylalanine and tyrosine, were connected to how long people live.
Amino acids are building blocks of protein. They are found in protein-rich foods such as milk, eggs and meat, and are also sold as dietary supplements.
How Zinc Protects Injured Arteries From Accelerated Aging
Researchers publishing in Aging Cell have discovered that the nuclei of the cells that line injured arteries quickly become misshapen and that this leads to accelerated cellular senescence. Delivering zinc to these cells partially alleviates this dysmorphism.
Two seemingly unrelated concepts
This paper begins with a discussion of two different concepts that, on the surface, appear to be unrelated. First, the researchers discuss vascular damage, particularly in the context of surgeries; even minimally invasive procedures that involve cutting, scraping, or burning arteries must cause some level of damage. This includes such procedures as catheter implantation as a treatment for heart disease [1] and the resection of cancerous tumors [2].
Exercise Triggers Memory-Related ‘Brain Ripples’, Study Finds
Exercise works wonders throughout the human body, including the brain.
Research suggests an array of neurological benefits, such as reducing the brain’s biological age, enhancing learning and memory, and protecting against dementia.
Now, a new study offers one of the clearest glimpses yet into a suspected mechanism: after a single 20-minute session of light-to-moderate cycling, people showed changes in memory-linked brain activity.
Dick Van Dyke Credits His Longevity to One Habit, And Science Supports It
Dick Van Dyke, the legendary American actor and comedian who starred in classics such as Mary Poppins and Chitty Chitty Bang Bang, turned 100 on December 13. The beloved actor credits his remarkable longevity to his positive outlook and never getting angry.
While longevity of course comes down to many factors – including genetics and lifestyle – there is some truth to Van Dyke’s claims.
Numerous studies have shown that keeping stress levels low and maintaining a positive, optimistic outlook are correlated with longevity.
Lifelong behavioral screen reveals an architecture of vertebrate aging
By tracking nearly every movement of a tiny fish’s life from adolescence to death, a new Science study reveals a hidden behavioral blueprint of aging—one that can predict a fish’s age or how long an individual will live.
Mapping behavior of individual vertebrate animals across lifespan could provide an unprecedented view into the lifelong process of aging. We created a platform for high-resolution continuous behavioral tracking of the African killifish across natural lifespan from adolescence to death. We found that animals follow distinct individual aging trajectories. The behaviors of long-lived animals differed markedly from those of short-lived animals, even relatively early in life, and were linked to organ-specific transcriptomic shifts. Machine-learning models accurately inferred age and even forecasted an individual’s future lifespan, given only behavior at a young age. Finally, we found that animals progressed through adulthood in a sequence of stable and stereotyped behavioral stages with abrupt transitions, revealing precise structure for an architecture of aging.
