Disease course and pathology an infection may cause can change owing to the structural and functional physiological changes that accumulate with age, but therapy can be tailored accordingly; disease tolerance genes show antagonistic pleiotropy.
Category: life extension
New Study Links Altered Cellular States to Brain Structure
Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life. The study, published January 22 in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.
Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined. Cellular senescence is commonly defined as a state characterized by permanent cell cycle arrest in the absence of cell death, in which cells have altered function. While cellular senescence has been implicated in aging and disease, its role in shaping human brain structure—both during development and aging—has remained unclear.
“This is the first study to directly link senescence-related molecular networks in living human brain tissue to measurable differences in brain structure within the same individuals,” said Noam Beckmann, PhD, Director of Data Sciences and founding member for the Mount Sinai Clinical Intelligence Center, Assistant Professor of Artificial Intelligence and Human Health, and co-senior author of the paper. “By identifying molecular pathways that are engaged in both brain structure development and aging, our work highlights senescence as a fundamental biological feature of brain aging and neurodegenerative disease and helps prioritize targets for future experimental research aimed at protecting brain health.”
Cellular senescence linked to brain structure changes across lifespan
Researchers at the Icahn School of Medicine at Mount Sinai have characterized how cellular senescence—a biological process in which aging cells change how they function—is associated with human brain structure in both development and late life.
The study, published in Cell, provides new insight into how molecular signatures of cellular senescence that are present during development and aging mirror those associated with brain volume and cortical organization.
Understanding brain structure is a central challenge in neuroscience. Although brain structure changes throughout life and is linked to both aging and neurodegenerative conditions such as Parkinson’s and Alzheimer’s diseases, the underlying molecular processes involved—including cellular senescence—are not defined.
Shingles Vaccine Linked to Slower Biological Aging, Study Finds
Vaccines may do far more than prevent infections.
The way that some inoculations train your immune system could also reduce the risk of cancer, stroke, or heart attacks, and possibly guard against dementia.
New evidence shows that the shingles vaccine is linked to slower aging, with benefits that can last for several years after vaccination.
Key protein can restore aging neural stem cells’ ability to regenerate
Researchers at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), have found that a key protein can help to regenerate neural stem cells, which may improve aging-associated decline in neuronal production of an aging brain.
Published in Science Advances, the study identified a transcription factor in the brain, cyclin D-binding myb-like transcription factor 1 (DMTF1), as a critical driver of neural stem cell function during the aging process. Transcription factors are proteins that regulate genes to ensure that they are expressed correctly in the intended cells.
The study, led by Assistant Professor Ong Sek Tong Derrick and first author Dr. Liang Yajing, both from the Department of Physiology and the Healthy Longevity Translational Research Program at NUS Medicine, sought to identify biological factors that influence the degeneration of neural stem cell function often associated with aging, and guide the development of therapeutic approaches to mitigate the adverse effects of neurological aging.
Moonshots with Peter Diamandis
Ray, you’ve made two predictions that I think are important. The first one, as you said, was the one you announced back in 1989: that we would reach human-level AI by 2029. And as you said, people laughed at it.
But there’s another prediction you’ve made: that we will reach the Singularity by 2045. There’s a lot of confusion here. In other words, if we reach human-level AI by 2029 and it then grows exponentially, why do we have to wait until 2045 for the Singularity? Could you explain the difference between these two?
It’s because that’s the point at which our intelligence will become a thousand times greater. One of the ways my view differs from others is that I don’t see it as us having our own intelligence—that is, biological intelligence—while AI exists somewhere else, and we interact with it by comparing human intelligence to AI.
Founder of XPRIZE and pioneer in exponential technologies. Building a world of Abundance through innovation, longevity, and breakthrough ventures.
Over 60 THIS Morning Habit TRIPLES Stroke Risk In Older Adults!
Over 60? THIS Morning Habit TRIPLES Stroke Risk In Older Adults! | Senior Health Tips.
Most people don’t know this, but the first 90 minutes after waking are the most dangerous for adults over 60 — especially when it comes to stroke risk. 🧠⚠️ New studies from Harvard, Tokyo, and Toronto reveal that certain common morning habits can dramatically increase vascular stress, spike blood pressure, restrict blood flow to the brain, and trigger dangerous clotting patterns in older adults. These habits look harmless on the outside, but inside the body, they create the perfect storm for a stroke. 😳
In this video, we reveal the 6 morning habits that triple stroke risk in seniors, ranked from least to most dangerous. You’ll learn why the aging vascular system reacts differently in the morning, why certain actions overload the arteries, how sudden pressure changes affect the brain, and the specific morning routines neurologists now warn older adults to avoid. We also explain what the research discovered about Habit #1 — a behavior so strongly linked to stroke risk that scientists repeated the study twice to confirm the results. 🧬📊
If you or someone you love is over 60, this is essential information. These morning habits can quietly raise your risk without symptoms, but the good news is that simple changes can help protect your brain, improve circulation, and lower your chances of experiencing a life-altering event. ❤️🩹 Stay until the end — your brain health may depend on it.
⌛Timestamps:
⏱️ Intro – 00:00
⚠️ Habit No.5 – 02:36
⚠️ Habit No.4 – 05:57
⚠️ Habit No.3 – 09:24
⚠️ Habit No.2 – 13:30
⚠️ Habit No.1 – 17:54
#SeniorHealth #SeniorHealthTips #SeniorWellness #SeniorZone #StrokeRisk #StrokePrevention #MorningHabits #Over60Health #BrainHealth #HealthyAging #SeniorSafety #HighBloodPressure #CirculationHealth #AgingWell #UnitedStates #Wisdom #NeurologyTips #SeniorCare #VascularHealth #HealthyMorningRoutine #LongevityTips.
The Singularity Countdown: AGI by 2029, Humans Merge with AI, Intelligence 1000x | Ray Kurzweil
Ray Kurzweil predicts humans will merge with artificial intelligence (AI) by 2045, resulting in a 1000x increase in intelligence and marking the beginning of a new era of unprecedented innovation, potentially transforming human life and society ## ## Questions to inspire discussion.
Preparing for AI Timeline.
🤖 Q: When should I expect human-level AI and what defines it? A: Human-level AI arrives by 2029, defined not by passing the Turing test (which only matches an ordinary person), but as AGI requiring expertise in thousands of fields and the ability to combine insights across disciplines.
🧠 Q: When will the singularity occur and what intelligence gain can I expect? A: The singularity happens by 2045 when humanity merges with AI to become 1000x more intelligent, creating a seamless merger where biological and computational thought processes become indistinguishable.
⚡ Q: How much change should I prepare for in the next decade? A: Expect as much change in the next 10 years as occurred in the last 100 years (1925−2025), with AGI and supercomputers by 2035 enabling merging with AI for 1000x intelligence increase.
Career and Economic Adaptation.
Turning MRI into a quantitative microscope to detect white matter injury
Early diagnosis and noninvasive monitoring of neurological disorders require sensitivity to elusive cellular-level alterations that emerge much earlier than volumetric changes observable with millimeter-resolution medical imaging.
Morphological changes in axons—the tube-like projections of neurons that transmit electrical signals and constitute the bulk of the brain’s white matter—are a common hallmark of a wide range of neurological disorders, as well as normal development and aging.
A study from the University of Eastern Finland (UEF) and the New York University (NYU) Grossman School of Medicine establishes a direct analytical link between the axonal microgeometry and noninvasive, millimeter-scale diffusion MRI (dMRI) signals—diffusion MRI measures the diffusion of water molecules within biological tissues and is sensitive to tissue microstructure.
