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Archive for the ‘life extension’ category

Jan 25, 2024

The fountain of youth is … a T cell?

Posted by in categories: biotech/medical, genetics, life extension

“If we give it to aged mice, they rejuvenate. If we give it to young mice, they age slower. No other therapy right now can do this.”


The fountain of youth has eluded explorers for ages. It turns out the magic anti-aging elixir might have been inside us all along.

Cold Spring Harbor Laboratory (CSHL) Assistant Professor Corina Amor Vegas and colleagues have discovered that T cells can be reprogrammed to fight aging, so to speak. Given the right set of genetic modifications, these white blood cells can attack another group of cells known as senescent cells. These cells are thought to be responsible for many of the diseases we grapple with later in life.

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Jan 25, 2024

Innovative silicon nanochip can reprogram biological tissue in living body

Posted by in categories: biotech/medical, computing, engineering, life extension, neuroscience, singularity

Year 2021 Biocomputing is the future for the biological singularity because we could control all inputs and outputs of our bodies even evolve them eventually.


A silicon device that can change skin tissue into blood vessels and nerve cells has advanced from prototype to standardized fabrication, meaning it can now be made in a consistent, reproducible way. As reported in Nature Protocols, this work, developed by researchers at the Indiana University School of Medicine, takes the device one step closer to potential use as a treatment for people with a variety of health concerns.

The technology, called tissue nanotransfection, is a non-invasive nanochip device that can reprogram tissue function by applying a harmless electric spark to deliver specific genes in a fraction of a second. In laboratory studies, the device successfully converted into to repair a badly injured leg. The technology is currently being used to reprogram tissue for different kinds of therapies, such as repairing caused by stroke or preventing and reversing nerve damage caused by diabetes.

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Jan 25, 2024

Scientists trick T-cells to resist aging, find fountain of youth within

Posted by in categories: biotech/medical, life extension

Researchers have discovered that T cells, which are white blood cells inside our bodies, can be reprogrammed to fight aging.

Jan 25, 2024

T Cells May Be The Living Anti-Aging Elixir

Posted by in categories: biotech/medical, genetics, life extension

The fountain of youth has eluded explorers for ages.


Summary: Researchers found that T cells can be genetically reprogrammed to target and eliminate senescent cells, which contribute to aging-related diseases. By using CAR (chimeric antigen receptor) T cells in mice, they achieved significant health improvements including lower body weight, enhanced metabolism, and increased physical activity.

This groundbreaking approach, offering long-term effects from a single treatment, could revolutionize treatments for age-related conditions like obesity and diabetes, transcending the potential of CAR T cells beyond their current use in cancer therapy.

Jan 24, 2024

Did High-Dose NMN Mess Up The Epigenetic Pace Of Aging?

Posted by in categories: genetics, life extension

Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Telomere, Epigenetic Testing: https://trudiagnostic.com/?irclickid=U-s3Ii2r7x

Jan 24, 2024

Inside the Quest to Reprogram Immune Cells Into An Anti-Aging Remedy

Posted by in category: life extension

New angle for increasing longevity:


In a new study, scientists found that T cells can be tweaked to fight damaged cells, called senescent cells, associated with aging.

Jan 24, 2024

New Antidepressant Could Restore The Body’s Ability to Fight Cancer

Posted by in categories: biotech/medical, life extension

I hope more research is fruitful because I got the doctor’s results from my recent colonoscopy. The polyps are benign but pre cancerous. I go back in 5 years and I’ll be eating healthier and exercising. I gotta admit I don’t feel great but it could be something I ate.


Scientists in China have demonstrated a new kind of antidepressant could also have the potential to restore the body’s ability to fight some types of cancer.

In strategic combination with anti-tumor drugs, the oral antidepressant ansofaxine hydrochloride appears to inhibit colon cancer cell growth in cell cultures and in mice, strengthening the immune system and inducing a form of programmed cell death.

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Jan 24, 2024

Recent advances in the evolution of aging and lifespan

Posted by in categories: biotech/medical, evolution, genetics, life extension

Aging is a common phenomenon among organisms, however, lifespan tends to vary across different species to a significant extent among vertebrates themselves. Aging occurs due to the gradual increase in DNA damage, disruption of cellular organelles, deregulation of protein function, disrupted metabolism and oxidative stress [1].

Longevity. Technology: The differences in lifespan are driven by trade-offs and evolutionary trajectories in the genomes of organisms. Age-specific selection also impacts allele (variations of a gene) frequencies in a population. This in turn impacts environment-specific mortality risk and disease susceptibility. Moreover, mutational processes are influenced by life history and age in both somatic and germline cells.

Now, a new review published in Trends in Genetics discusses recent advances in the evolution of aging at population, organismal and cellular scales.

Jan 24, 2024

Causality-enriched epigenetic age uncouples damage and adaptation

Posted by in categories: genetics, life extension

The authors identify causality-enriched CpGs linked to aging using Mendelian randomization. They develop new epigenetic clocks, DamAge and AdaptAge, that more reliably track age-related changes, offering insights into aging mechanisms and interventions.

Jan 23, 2024

Why I’m Not Afraid of Death

Posted by in category: life extension

Here we have a deathist vid. This fellow does run a good channel, cool bloke. But he seems to think longer life means you’ll just never be motivated and only the knowledge of death with get you moving in life. I did leave a comment.

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