Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: life extension

‘Tour de force’ mouse study shows a gut microbe can promote memory loss

Scientists have plenty of ideas about why aging impairs memory. Reductions in blood flow in the brain, shrinking brain volume, and malfunctioning neural repair systems have all been blamed. Now, new research in mice points to another possible culprit: microbes in the gut.

In a new study, scientists show how a bacterium that is particularly common in older animals can drive memory loss. This microbe makes compounds that impair signaling along neurons connecting the gut with the brain, dampening activity in brain regions associated with learning and memory, the team found.

Research suggests the microbiome may contribute to cognitive decline—but its relevance in humans is unclear.

Ageing promotes metastasis via activation of the integrated stress response

Ageing reprograms the evolutionary trajectory of KRAS-driven lung adenocarcinoma, limiting primary tumour growth while promoting metastatic dissemination through epigenetic activation of the integrated stress response, and a therapeutic opportunity in older patients is revealed.

Popular Anti-Aging Supplement May Fuel Cancer Growth — Here’s Why

This actually offers some significant new insights for both cancer treatment research and the development of anti-aging therapies. 🧠

Read more👇

A group of natural compounds attracting attention for their anti-aging potential has a dark side.

New research shows how a family of chemicals called polyamines speeds up the growth of cancer cells. Led by a team from the Tokyo University of Science in Japan, the study offers some significant new insights for both cancer treatment research and the development of anti-aging therapies.

Polyamines are essential molecules found in all living cells. Including compounds with colorful names like spermidine and putrescine, they regulate processes involving cell growth and protein synthesis.

Secondary bile acids as immune and metabolic mediators

The human liver makes two primary bile acids that are cholesterol derivates, while, intestinal microbiota is the source of hundreds of secondary bile acids and microbially conjugated bile acids.

A dysbiotic microbiota releases altered quantities and varieties of secondary bile acids, which contribute to intestinal and systemic immune dysregulation.

In this review the authors discuss recent advances in secondary bile acids, the intestinal microbiota generating them, and their role in immune disorders. sciencenewshighlights ScienceMission https://sciencemission.com/Secondary-bile-acids

Bile acids are cholesterol derivatives, generated by the coordinated intervention of human and bacterial genes, functioning as endogenous ligands for multiple transcription factors and receptors throughout the body. While only two primary bile acids are generated by the human liver, the intestinal microbiota is the source of hundreds of secondary bile acids and microbially conjugated bile acids. Secondary bile acids regulate immune function throughout the body, promote the conversion of thyroid hormone, and regulate energy expenditure in muscle and adipose tissues, ultimately contributing to the beneficial effects of calorie restriction on human health and longevity. Here, we discuss recent advances in our understanding of secondary bile acids, the intestinal microbiota generating them, and their role in immune disorders.

Artificial kinetochores take the pressure off aging chromosomes during meiosis

For sexual reproduction to yield healthy offspring, newly generated oocytes—immature egg cells—must receive the correct amount of DNA after cell division. This process of segregating chromosomes becomes more prone to failure as we age. Now, RIKEN researchers have identified a strategy that could help to prevent such errors and restore healthy production of oocytes.

Oocytes are produced by a cell-division process known as meiosis, during which every chromosome is duplicated. These replicates form X-shaped structures in which the chromosomes are joined via structures called centromeres, where a protein called cohesin locks chromosome copies together.

As division proceeds, protein fibers called microtubules spread from opposite poles of the dividing cell, attaching to each chromosome. These microtubules eventually pull the two apart, so that each newly formed cell receives one copy of each chromosome.

Abstract: Glioblastoma remains profoundly resistant to current immunotherapeutic strategies

Here, Fanghui Lu & team report OLIG2, a master transcription factor in glioblastoma stem cells, enables immune evasion by suppressing CXCL10. And, targeting OLIG2 overcomes immunotherapy resistance and improves survival.

1Department of Cancer Center, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

2Department of Neurosurgery, Key Laboratory of Major Brain Disease and Aging Research (Ministry of Education), The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

3School of Basic Medical Sciences, Chongqing Medical University, Chongqing, China.

Robust Mouse Rejuvenation: Breaking the Ceiling of Longevity Research

For decades, the field of biogerontology has largely focused on a single strategy: manipulating metabolism to slow down the rate at which we age. While approaches like caloric restriction have produced fascinating results in short-lived organisms like worms and flies, they have shown clear limits in mammals. Slowing the accumulation of damage does not remove the damage that is already there. It merely delays (not prevents) the onset of disease, particularly when applied late in life.

Your gut microbes can be anti-aging—scientists are uncovering how to keep your microbiome youthful

People have long given up on the search for the Fountain of Youth, a mythical spring that could reverse aging. But for some scientists, the hunt has not ended—it’s just moved to a different place. These modern-day Ponce de Leóns are investigating whether gut microbes hold the secret to aging well.

The gut microbiome refers to the vast collection of microscopic organisms—bacteria, fungi, and viruses—that largely inhabit the colon. These microbes aid in digestion and produce molecules that affect your physiology and psychology. The composition of the microbiome is influenced by a combination of factors, including genetics, diet, the environment, medications, and age.

I’m a microbiology professor and author of “Pleased to Meet Me: Genes, Germs and the Curious Forces That Make Us Who We Are,” which describes how the gut microbiome contributes to physical and mental health. The discovery that the gut microbiome changes with age has ignited studies to determine whether the Fountain of Youth might be right under your nose, down inside your gut.

/* */