Archive for the ‘life extension’ category

Jan 11, 2023

This biotech startup says mice live longer after genetic reprogramming

Posted by in categories: biotech/medical, genetics, life extension

The result is a widely anticipated landmark for rejuvenation technology.

Jan 11, 2023

Ants Live 10 Times Longer

Posted by in categories: genetics, life extension

Queen ants live far longer than genetically identical workers. Researchers are learning what their longevity secrets could mean for aging in other species.

Jan 11, 2023

Short Reprogramming To Reverse Cellular Aging | Dr Vittorio Sebastiano Interview Clips

Posted by in categories: biotech/medical, genetics, life extension

Dr Vittorio Sebastiano presents about aging and reprogramming and answers questions from audience in this clip. He specifies short Reprogramming does not impact cellular Identity but Impact cellular age and cellular health.

Dr. Vittorio Sebastiano is an Assistant Professor in the Department of Obstetrics and Gynecology at Stanford School of Medicine. His lab has established a new technology named ERA (Epigenetic Reprogramming of Aging), which repurposes the conceptual idea of reprogramming, with the goal to promote epigenetic rejuvenation of adult cells leaving their identity untouched. This new technology was patented and is being implemented by Turn Biotechnologies, of which Dr. Sebastiano is co-founder and Chair of the Scientific Advisory Board.

Continue reading “Short Reprogramming To Reverse Cellular Aging | Dr Vittorio Sebastiano Interview Clips” »

Jan 10, 2023

Earlier Health Conditions Tied to Subsequent Dementia

Posted by in categories: biotech/medical, life extension, neuroscience

Some health conditions associated with appeared early and consistently long before diagnosis, while others became significant much later, a cohort study suggested.

For people with a subsequent diagnosis of Alzheimerโ€™s disease, the earliest and most consistent associations at all time points over a 15-year span included depression, erectile dysfunction, gait abnormalities, hearing loss, and nervous and musculoskeletal symptoms, reported Lori Beason-Held, PhD, of the National Institute on Aging in Baltimore, and co-authors.

For those eventually diagnosed with vascular, the earliest and most consistent associations across 13 years were an abnormal electrocardiogram (EKG), cardiac dysrhythmias, cerebrovascular disease, non-epithelial skin cancer, depression, and hearing loss, the researchers reported in Annals of Neurology.

Jan 10, 2023

Aubrey de Grey on LEVF and Robust Mouse Rejuvenation

Posted by in categories: biotech/medical, life extension

Dr. Aubrey de Grey is a legend in the longevity field who has been steadfastly promoting the idea of life extension since well before it became mainstream. While with SENS Research Foundation, de Grey made significant contributions to geroscience, and at Longevity Summit Dublin last year, he announced the creation of his new brainchild, Longevity Escape Velocity Foundation (LEVF).

Now, the first major and long-awaited LEVF-funded project is being launched: Robust Mouse Rejuvenation (RMR). This is envisioned as a rolling research program aiming to increase both the mean and maximum lifespan of mice by at least 12 months with various combination therapies started late in life. For the first study, four therapies have been chosen: rapamycin, a senolytic, hematopoietic stem cell transplantation (HSCT), and telomerase expression. A groundbreaking experiment by any measure, RMR got us excited, and we reached out to Aubrey to discuss both RMR and LEVF in depth.

The following interview has Arkadi asking questions in bold and Aubrey de Grey answering in normal font.

Jan 10, 2023

Scientists reprogrammed miceโ€™s genes to live longer, and it worked!

Posted by in categories: biotech/medical, life extension

Time to reverse your age and restore youth.

Scientists at a San Diego-based biotech company Rejuvenate Bio claim to have increased the age of mice by reprogramming their genes. They believe their gene therapy actually works like a reverse aging technique that one day might be used for rejuvenating humans.

Continue reading “Scientists reprogrammed miceโ€™s genes to live longer, and it worked!” »

Jan 10, 2023

Brain Area Necessary for Fluid Intelligence Identified โ€” Defining Feature of Human Cognition

Posted by in categories: biotech/medical, education, life extension, neuroscience

๐๐ซ๐š๐ข๐ง ๐€๐ซ๐ž๐š ๐๐ž๐œ๐ž๐ฌ๐ฌ๐š๐ซ๐ฒ ๐Ÿ๐จ๐ซ ๐…๐ฅ๐ฎ๐ข๐ ๐ˆ๐ง๐ญ๐ž๐ฅ๐ฅ๐ข๐ ๐ž๐ง๐œ๐ž ๐ˆ๐๐ž๐ง๐ญ๐ข๐Ÿ๐ข๐ž๐ โ€” ๐ƒ๐ž๐Ÿ๐ข๐ง๐ข๐ง๐  ๐…๐ž๐š๐ญ๐ฎ๐ซ๐ž ๐จ๐Ÿ ๐‡๐ฎ๐ฆ๐š๐ง ๐‚๐จ๐ ๐ง๐ข๐ญ๐ข๐จ๐ง

๐˜ผ ๐™ฉ๐™š๐™–๐™ข ๐™ก๐™š๐™™ ๐™—๐™ฎ ๐™๐™ฃ๐™ž๐™ซ๐™š๐™ง๐™จ๐™ž๐™ฉ๐™ฎ ๐˜พ๐™ค๐™ก๐™ก๐™š๐™œ๐™š ๐™‡๐™ค๐™ฃ๐™™๐™ค๐™ฃ (๐™๐˜พ๐™‡) ๐™–๐™ฃ๐™™ ๐™๐™ฃ๐™ž๐™ซ๐™š๐™ง๐™จ๐™ž๐™ฉ๐™ฎ ๐˜พ๐™ค๐™ก๐™ก๐™š๐™œ๐™š ๐™‡๐™ค๐™ฃ๐™™๐™ค๐™ฃ ๐™ƒ๐™ค๐™จ๐™ฅ๐™ž๐™ฉ๐™–๐™ก๐™จ (๐™๐˜พ๐™‡๐™ƒ) ๐™ง๐™š๐™จ๐™š๐™–๐™ง๐™˜๐™๐™š๐™ง๐™จ ๐™๐™–๐™จ ๐™ข๐™–๐™ฅ๐™ฅ๐™š๐™™ ๐™ฉ๐™๐™š ๐™ฅ๐™–๐™ง๐™ฉ๐™จ ๐™ค๐™› ๐™ฉ๐™๐™š ๐™—๐™ง๐™–๐™ž๐™ฃ ๐™ฉ๐™๐™–๐™ฉ ๐™จ๐™ช๐™ฅ๐™ฅ๐™ค๐™ง๐™ฉ ๐™ค๐™ช๐™ง ๐™–๐™—๐™ž๐™ก๐™ž๐™ฉ๐™ฎ ๐™ฉ๐™ค ๐™จ๐™ค๐™ก๐™ซ๐™š ๐™ฅ๐™ง๐™ค๐™—๐™ก๐™š๐™ข๐™จ ๐™ฌ๐™ž๐™ฉ๐™๐™ค๐™ช๐™ฉ ๐™ฅ๐™ง๐™ž๐™ค๐™ง ๐™š๐™ญ๐™ฅ๐™š๐™ง๐™ž๐™š๐™ฃ๐™˜๐™š โ€” ๐™ค๐™ฉ๐™๐™š๐™ง๐™ฌ๐™ž๐™จ๐™š ๐™ ๐™ฃ๐™ค๐™ฌ๐™ฃ ๐™–๐™จ ๐™›๐™ก๐™ช๐™ž๐™™ ๐™ž๐™ฃ๐™ฉ๐™š๐™ก๐™ก๐™ž๐™œ๐™š๐™ฃ๐™˜๐™š. ๐™๐™ก๐™ช๐™ž๐™™ ๐™ž๐™ฃ๐™ฉ๐™š๐™ก๐™ก๐™ž๐™œ๐™š๐™ฃ๐™˜๐™š ๐™ž๐™จ ๐™–๐™ง๐™œ๐™ช๐™–๐™—๐™ก๐™ฎ ๐™ฉ๐™๐™š ๐™™๐™š๐™›๐™ž๐™ฃ๐™ž๐™ฃ๐™œ ๐™›๐™š๐™–๐™ฉ๐™ช๐™ง๐™š ๐™ค๐™› ๐™๐™ช๐™ข๐™–๐™ฃ ๐™˜๐™ค๐™œ๐™ฃ๐™ž๐™ฉ๐™ž๐™ค๐™ฃ. ๐™„๐™ฉ ๐™ฅ๐™ง๐™š๐™™๐™ž๐™˜๐™ฉ๐™จ ๐™š๐™™๐™ช๐™˜๐™–๐™ฉ๐™ž๐™ค๐™ฃ๐™–๐™ก ๐™–๐™ฃ๐™™ ๐™ฅ๐™ง๐™ค๐™›๐™š๐™จ๐™จ๐™ž๐™ค๐™ฃ๐™–๐™ก ๐™จ๐™ช๐™˜๐™˜๐™š๐™จ๐™จ, ๐™จ๐™ค๐™˜๐™ž๐™–๐™ก ๐™ข๐™ค๐™—๐™ž๐™ก๐™ž๐™ฉ๐™ฎ, ๐™๐™š๐™–๐™ก๐™ฉ๐™, ๐™–๐™ฃ๐™™ ๐™ก๐™ค๐™ฃ๐™œ๐™š๐™ซ๐™ž๐™ฉ๐™ฎ. ๐™„๐™ฉ ๐™–๐™ก๐™จ๐™ค ๐™˜๐™ค๐™ง๐™ง๐™š๐™ก๐™–๐™ฉ๐™š๐™จ ๐™ฌ๐™ž๐™ฉ๐™ ๐™ข๐™–๐™ฃ๐™ฎ ๐™˜๐™ค๐™œ๐™ฃ๐™ž๐™ฉ๐™ž๐™ซ๐™š ๐™–๐™—๐™ž๐™ก๐™ž๐™ฉ๐™ž๐™š๐™จ ๐™จ๐™ช๐™˜๐™ ๐™–๐™จ ๐™ข๐™š๐™ข๐™ค๐™ง๐™ฎ.

A team led by University College London (UCL) and University College London Hospitals (UCLH) researchers has mapped the parts of the brain that support our ability to solve problems without prior experience โ€“ otherwise known as fluid intelligence.

Continue reading “Brain Area Necessary for Fluid Intelligence Identified โ€” Defining Feature of Human Cognition” »

Jan 10, 2023

Healthy aging and drinking water: Fascinating findings from a new study

Posted by in categories: biotech/medical, life extension

Nearly half of people worldwide do not get the recommended daily total water intake, a new report indicates.

Yet drinking enough water may help to delay the aging process for many.

A recent study by the National Institutes of Health (NIH) published in eBioMedicine suggests as much โ€” though there are caveats to know.

Jan 9, 2023

Mouse model shows obesity in early life promotes later inflammatory disease, even after weight loss

Posted by in categories: biotech/medical, genetics, life extension

A team of researchers affiliated with multiple institutions in Canada has found that obesity in young mice can lead to inflammatory disease later in life even if the mouse is no longer overweight. In their paper published in the journal Science, the group describes studying early life obesity in test mice and the development of age-related macular degeneration. Kevin Mangum and Katherine Gallagher with the University of Michigan have published a Perspectives piece in the same journal issue outlining the research.

Age-related (AMD) in older people can lead to permanent blindness. Prior research has shown obesity plays a major role in its development. Other research has also shown that AMD is a neuroinflammatory condition. It is believed that the inflammation in the eyes is related to obesity, but the exact connection has not been identified. In this new effort, the researchers sought to find the connection by studying obesity and macular degeneration in mice.

The work involved feeding a and studying the impact on adipose tissue macrophages (types of white blood cells that are part of the immune system). They found that obesity in mice led to epigenetic changes in the macrophages that resulted in an increase in expression of genes that incite an inflammatory response. They also found that the increased expression continued even after the test mice were put on a reduced diet that allowed them to return to their normal weight.

Jan 9, 2023

Experts fear billionaires like Elon Musk and Jeff Bezos will become immortal

Posted by in categories: Elon Musk, life extension

Experts are worried the worldโ€™s richest billionaires, including Elon Musk and Jeff Bezos, will be able to stave off aging and use their immense wealth to live longer than any human being has before.

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