Anti-aging drugs are being trialed in companion dogs—but the goal is to find ways to have people, as well as beloved pets, live longer, healthier lives.
Category: life extension
Enhanced non-enzymatic H2S generation extends lifespan and healthspan in male mice
Cáliz-Molina et al. demonstrate that hydrogen sulfide generators found in garlic extend lifespan and enhance metabolic, neurocognitive, and locomotor function in male mice. These molecules induce hepatic lipid-droplet remodeling and modulate aging-associated pathways at transcriptomic, proteomic, and persulfidomic levels. In humans, increased cysteine persulfidation correlates with relevant aspects of health.
Heart-brain connection via vagus nerve to keep the heart young
The secret to a healthier and “younger” heart lies in the vagus nerve. A recent study published in Science Translational Medicine has shown that preserving bilateral cardiac vagal innervation is an anti-aging factor. In particular, the right cardiac vagus nerve emerges as a true guardian of cardiomyocyte health, helping to preserve the longevity of the heart independently of heart rate.
‘When the integrity of the connection to the vagus nerve is lost, the heart ages more rapidly,’ explains the senior author.
‘Even partial restoration of the connection between the right vagus nerve and the heart is sufficient to counteract the mechanisms of remodelling and preserve effective cardiac contractility,’ adds another author.
‘We have developed an implantable bioabsorbable nerve conduit designed to promote and guide the spontaneous regeneration of the thoracic vagus nerve at the cardiac level,’ explains a co-author.
Treated adult male minipigs displayed improved global circumferential, longitudinal, and radial strains and reduced diastolic dyssynchrony. Histological analysis revealed partial repair with about 20% viable vagal fascicles, restoration of myocardial parasympathetic fibers, normalization of oxidative stress and aging markers, and prevention of interstitial fibrosis.
Mathematics uncovers shifting brain connectivity in autism and aging
It is a central question in neuroscience to understand how different regions of the brain interact, how strongly they “talk” to each other. Researchers from the Max Planck Institute for Mathematics in the Sciences Leipzig, Germany, the Institute of Mathematical Sciences in Chennai, India, and colleagues demonstrate how mathematical techniques from topological data analysis (TDA) can provide a new, multiscale perspective on brain connectivity. The study was published in the journal Patterns.
With the rise of large neuroimaging datasets, scientists now work with detailed maps of brain connectivity—network representations that show how hundreds of brain regions fluctuate and coordinate their activity over time. But making sense of these enormous networks poses a challenge: What patterns matter? Which changes signal healthy aging, and which reflect differences associated with autism spectrum disorder (ASD)?
The study introduces a mathematical innovation that helps answer precisely these questions. Researchers applied persistent homology, a tool from topological data analysis (TDA), to detect how brain connectivity reorganizes during healthy aging and in ASD.
Elon Musk on AGI Timeline, US vs China, Job Markets, Clean Energy & Humanoid Robots
Questions to inspire discussion.
🤖 Q: How quickly will AI and robotics replace human jobs? A: AI and robotics will do half or more of all jobs within the next 3–7 years, with white-collar work being replaced first, followed by blue-collar labor through humanoid robots.
🏢 Q: What competitive advantage will AI-native companies have? A: Companies that are entirely AI-powered will demolish competitors, similar to how a single manually calculated cell in a spreadsheet makes it unable to compete with entirely computer-based spreadsheets.
💼 Q: What forces companies to adopt more AI? A: Companies using more AI must outcompete those using less, creating a forcing function for increased AI adoption, as inertia currently keeps humans doing AI-capable tasks.
📊 Q: How much of enterprise software development can AI handle autonomously? A: Blitzy, an AI platform using thousands of specialized agents, autonomously handles 80%+ of enterprise software development, increasing engineering velocity 5x when paired with human developers.
Energy and Infrastructure.
NMNH Triples NAD+ in First Human Trial: Here’s What That Means
The first NMNH human trial shows NAD+ levels increased up to 3x in 90 days. Here’s what the data actually reveal—and what’s still missing.
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The first human clinical trial results for NMNH are here. In this 90-day randomized, double-blind, placebo-controlled study, NMNH increased NAD+ levels up to 3x in healthy adults, with participants reporting improvements in energy and fatigue. But before you get too excited, there are important limitations to understand.
In this video, I break down the trial design, explain what the NAD+ increases actually mean, review the subjective outcomes like energy and emotional well-being (measured via SF-36), and discuss why the biological age claims are difficult to interpret. I also cover safety data and what we still need to know.
This is promising early data for NMNH vs NMN, but it’s unpublished, lacks key details, and needs independent replication. Here’s everything you need to know about what this trial does and doesn’t tell us.
Key topics: NMNH clinical trial, NAD+ boosters, NMN vs NMNH, longevity supplements, anti-aging research, NAD+ levels, UthPeak study, Phase I trial results.
📚 Chapters.
0:00 — Introduction & Trial Overview What this video covers and the trial basics.
1:39 — Trial Design & Methodology Study structure, participants, and objectives.
2:31 — NAD+ Results The primary outcome: dose-dependent increases.
3:18 — Subjective Outcomes & Limitations Energy, mood, biological age claims, and why interpretation is difficult.
6:26 — Safety & Final Thoughts Tolerability data and what comes next.
🌐Links in this video.
NMNH Clinical Trial https://www.clinicaltrials.gov/study/.… nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice https://faseb.onlinelibrary.wiley.com… Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth https://pubmed.ncbi.nlm.nih.gov/33793… *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ********************************************** #nmnh #nad #nmn.
Reduced nicotinamide mononucleotide is a new and potent NAD+ precursor in mammalian cells and mice.
https://faseb.onlinelibrary.wiley.com…
Reduced Nicotinamide Mononucleotide (NMNH) Potently Enhances NAD+ and Suppresses Glycolysis, the TCA Cycle, and Cell Growth.
https://pubmed.ncbi.nlm.nih.gov/33793…
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