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Archive for the ‘sex’ category

May 14, 2022

14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021

Posted by in categories: biotech/medical, economics, health, sex, surveillance

New estimates from the World Health Organization (WHO) show that the full death toll associated directly or indirectly with the COVID-19 pandemic (described as “excess mortality”) between 1 January 2020 and 31 December 2021 was approximately 14.9 million (range 13.3 million to 16.6 million). “These sobering data not only point to the impact of the pandemic but also to the need for all countries to invest in more resilient health systems that can sustain essential health services during crises, including stronger health information systems,” said Dr Tedros Adhanom Ghebreyesus, WHO Director-General. “WHO is committed to working with all countries to strengthen their health information systems to generate better data for better decisions and better outcomes.” Excess mortality is calculated as the difference between the number of deaths that have occurred and the number that would be expected in the absence of the pandemic based on data from earlier years. Excess mortality includes deaths associated with COVID-19 directly (due to the disease) or indirectly (due to the pandemic’s impact on health systems and society). Deaths linked indirectly to COVID-19 are attributable to other health conditions for which people were unable to access prevention and treatment because health systems were overburdened by the pandemic. The estimated number of excess deaths can be influenced also by deaths averted during the pandemic due to lower risks of certain events, like motor-vehicle accidents or occupational injuries. Most of the excess deaths (84%) are concentrated in South-East Asia, Europe, and the Americas. Some 68% of excess deaths are concentrated in just 10 countries globally. Middle-income countries account for 81% of the 14.9 million excess deaths (53% in lower-middle-income countries and 28% in upper-middle-income countries) over the 24-month period, with high-income and low-income countries each accounting for 15% and 4%, respectively. The estimates for a 24-month period (2020 and 2021) include a breakdown of excess mortality by age and sex. They confirm that the global death toll was higher for men than for women (57% male, 43% female) and higher among older adults. The absolute count of the excess deaths is affected by the population size. The number of excess deaths per 100,000 gives a more objective picture of the pandemic than reported COVID-19 mortality data.“Measurement of excess mortality is an essential component to understand the impact of the pandemic. Shifts in mortality trends provide decision-makers information to guide policies to reduce mortality and effectively prevent future crises. Because of limited investments in data systems in many countries, the true extent of excess mortality often remains hidden,” said Dr Samira Asma, Assistant Director-General for Data, Analytics and Delivery at WHO. “These new estimates use the best available data and have been produced using a robust methodology and a completely transparent approach.”“Data is the foundation of our work every day to promote health, keep the world safe, and serve the vulnerable. We know where the data gaps are, and we must collectively intensify our support to countries, so that every country has the capability to track outbreaks in real-time, ensure delivery of essential health services, and safeguard population health,” said Dr Ibrahima Socé Fall, Assistant Director-General for Emergency Response. The production of these estimates is a result of a global collaboration supported by the work of the Technical Advisory Group for COVID-19 Mortality Assessment and country consultations. This group, convened jointly by the WHO and the United Nations Department of Economic and Social Affairs (UN DESA), consists of many of the world’s leading experts, who developed an innovative methodology to generate comparable mortality estimates even where data are incomplete or unavailable. This methodology has been invaluable as many countries still lack capacity for reliable mortality surveillance and therefore do not collect and generate the data needed to calculate excess mortality. Using the publicly available methodology, countries can use their own data to generate or update their own estimates. “The United Nations system is working together to deliver an authoritative assessment of the global toll of lives lost from the pandemic. This work is an important part of UN DESA’s ongoing collaboration with WHO and other partners to improve global mortality estimates,” said Mr Liu Zhenmin, United Nations Under-Secretary-General for Economic and Social Affairs. Mr Stefan Schweinfest, Director of the Statistics Division of UN DESA, added: “Data deficiencies make it difficult to assess the true scope of a crisis, with serious consequences for people’s lives. The pandemic has been a stark reminder of the need for better coordination of data systems within countries and for increased international support for building better systems, including for the registration of deaths and other vital events.” Note for editors: The methods were developed by the Technical Advisory Group for COVID-19 Mortality Assessment, co-chaired by Professor Debbie Bradshaw and Dr. Kevin McCormack with extensive support from Professor Jon Wakefield at the University of Washington. The methods rely on a statistical model derived using information from countries with adequate data; the model is used to generate estimates for countries with little or no data available. The methods and estimates will continue to be updated as additional data become available and in consultation with countries.

May 10, 2022

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice

Posted by in categories: biotech/medical, life extension, sex

Pharmaceutical intervention of aging requires targeting multiple pathways, thus there is rationale to test combinations of drugs targeting different but overlapping processes. In order to determine if combining drugs shown to extend lifespan and healthy aging in mice would have greater impact than any individual drug, a cocktail diet containing 14 ppm rapamycin, 1,000 ppm acarbose, and 1,000 ppm phenylbutyrate was fed to 20-month-old C57BL/6 and HET3 4-way cross mice of both sexes for three months. Mice treated with the cocktail showed a sex and strain-dependent phenotype consistent with healthy aging including decreased body fat, improved cognition, increased strength and endurance, and decreased age-related pathology compared to mice treated with individual drugs or control. The severity of age-related lesions in heart, lungs, liver, and kidney was consistently decreased in mice treated with the cocktail compared to mice treated with individual drugs or control, suggesting an interactive advantage of the three drugs. This study shows that a combination of three drugs, each previously shown to enhance lifespan and health span in mice, is able to delay aging phenotypes in middle-aged mice more effectively than any individual drug in the cocktail over a 3-month treatment period.

© 2022. The Author(s).

Conflict of interest statement.

May 8, 2022

Blood Test Analysis: Italian Centenarians

Posted by in categories: biotech/medical, life extension, robotics/AI, sex

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Biomarker timestamps:
Glucose 1:37
HDL 2:43
Triglycerides 4:10
RBCs, Hemoglobin 5:29
Platelets 7:16
Uric Acid 8:37
AST, ALT 11:04
Total Cholesterol 13:55
WBCs 15:47
Total Protein, Albumin, Globulin 17:38
Creatinine 21:27
BUN 22:35

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Apr 25, 2022

163 years later, new research challenges Darwin’s most famous theory about sex

Posted by in categories: biological, sex

Do Charles Darwin’s ideas on sexual selection hold up today? The biologist was very much of his time, which meant it may have shaped his understanding of evolutionary biology.

Apr 22, 2022

Elon Musk Says He Could Make “Catgirl” Sex Robots If He Wanted To

Posted by in categories: Elon Musk, robotics/AI, sex

To SpaceX and Tesla CEO Elon Musk, the future is teeming with humanoid robots.

During a lengthy and freewheeling conversation with TED’s Chris Anderson last week, Musk expanded on his vision of what it could look like to share everyday life with automatons doing our bidding.

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Apr 19, 2022

100 Million-Year-Old Fairy Shrimp Reproduced Without Sex, Rare Fossils Reveal

Posted by in category: sex

Cretaceous period fossils indicate female fairy shrimp had no need for males.

Mar 27, 2022

Blood Test #2 in 2022: Supplements, Cardiovascular Fitness Metrics (HRV, RHR)

Posted by in categories: biotech/medical, life extension, sex

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Levine’s Biological age calculator is embedded as an Excel file in this link from my website:
https://michaellustgarten.com/2019/09/09/quantifying-biological-age/

Continue reading “Blood Test #2 in 2022: Supplements, Cardiovascular Fitness Metrics (HRV, RHR)” »

Mar 13, 2022

The Association For Low LDL With An Increased CVD Mortality Risk Is Impacted

Posted by in categories: biotech/medical, chemistry, sex

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Papers referenced in the video:
Association between low-density lipoprotein cholesterol and cardiovascular mortality in statin non-users: a prospective cohort study in 14.9 million Korean adults.
https://pubmed.ncbi.nlm.nih.gov/35218344/

Continue reading “The Association For Low LDL With An Increased CVD Mortality Risk Is Impacted” »

Mar 6, 2022

Centenarian Blood Test Analysis (n=1,754; Part II)

Posted by in categories: biotech/medical, life extension, robotics/AI, sex

(Part II) Centenarian Blood Test Analysis (n=1,754)


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Continue reading “Centenarian Blood Test Analysis (n=1,754; Part II)” »

Feb 20, 2022

Middle-of-the-Night Melatonin Supplementation: Better Sleep, Improved HRV and RHR?

Posted by in categories: biotech/medical, life extension, sex

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Papers referenced in the video:
Melatonin, human aging, and age-related diseases.
https://pubmed.ncbi.nlm.nih.gov/15582288/

Continue reading “Middle-of-the-Night Melatonin Supplementation: Better Sleep, Improved HRV and RHR?” »

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