Toggle light / dark theme

Optimal CXCR5 expression during Tfh maturation involves the Bhlhe40-Pou2af1 axis

The Bcl6-Blimp-1 axis plays a critical role in follicular T helper (Tfh) cell fate determination; however, the regulation of CXCR5 expression during Tfh maturation is still elusive. Zhu et al. report that the Bhlhe40-Pou2af1 pair regulates optimal expression of CXCR5 and Tfh cell migration into germinal centers without affecting Bcl6 induction.

Donate to My War with cancer in 2025 and other major setbacks, organized by Nicholas Avery

I hope this message finds you well. My name is Nick, and I am writing to you in the spirit of openness and honesty. In 2025 I underwent emergency medical treatment for a skull tumor, and after initial interventions failed I received CAR T-cell therapy at City of Hope Cancer Centers in California. This journey along with the rest of the year has been one of the most challenging years of my life.

Because of cancer treatments and multiple hardships throughout the year, medical bills, recovery needs, a car accident, and not allowed to return to work yet, I established a GoFundMe campaign to help cover necessary expenses and give myself a chance at recovery and Here’s the link to the campaign:

https://gofund.me/546bee7a8

I understand Lifeboat core values and mission is towards making the world a better place and after years of growing with this community, which is why I believe that human life, is a part of what makes our future worth safeguarding.

I’m reaching out because we all have our own personal humanitarian crisis and unfortunate this year is mine. I appreciate any support, be it words of encouragement or donating to my campaign is all deeply appreciated. Thank you for letting me a part of this community. The link is posted in a comment.

A special THANK YOU to Eric Klien for being supportive and donating.


Windows is rolling out the ability to handle all app updates from just your OS, but with limited support right now

Good news, an actually good Windows update is here. But it likely won’t be useful for a while. Still, the foundation has been laid for your apps to update themselves thanks to the introduction of the Unified Update Orchestration Platform (UOP).

The UOP will “download and install updates based on user activity and system state”. Though rather than Windows Update, which provides patches for the OS and some applications and services, or Microsoft Store, UOP allows apps to stick to their own backend updating service. So, think of it like the OS helping apps to download updates when the system isn’t in use.

/* */