Archive for the ‘biotech/medical’ category

Jul 7, 2019

High cholesterol ‘does not cause heart disease’ new research finds, so treating with statins a ‘waste of time’

Posted by in category: biotech/medical

Cholesterol does not cause heart disease in the elderly and trying to reduce it with drugs like statins is a waste of time, an international group of experts has claimed.

A review of research involving nearly 70,000 people found there was no link between what has traditionally been considered “bad” cholesterol and the premature deaths of over 60-year-olds from cardiovascular disease.

Published in the BMJ Open journal, the new study found that 92 percent of people with a high cholesterol level lived longer.

Jul 6, 2019

Doctors Now Prescribing Music Therapy for Heart Ailments, Brain Dysfunction, Learning Disabilities, Depression, PTSD, Alzheimers, Childhood Development and More

Posted by in categories: biotech/medical, media & arts, neuroscience

Music has proven time and again to be an important component of human culture. From its ceremonial origin to modern medical usage for personal motivation, concentration, and shifting mood, music is a powerful balm for the human soul. Though traditional “music therapy” encompasses a specific set of practices, the broader use of music as a therapeutic tool can be seen nowadays as doctors are found recommending music for a wide variety of conditions.

Jul 6, 2019

Researchers use kirigami to spin terahertz rays

Posted by in categories: biotech/medical, encryption

CHICAGO, July 2 (Xinhua) — With a light-spinning device inspired by the Japanese art of paper cutting, researchers at the University of Michigan (UM) have detected microscopic twists in the internal structure of plant and animal tissue without harmful X-rays.

The approach is the first that can fully rotate terahertz radiation in real time, and could open new dimensions in medical imaging, encrypted communications and cosmology, according to a news release posted on UM’s website on Monday.

With an eye to exploring how chirality may help distinguish tissues, the researchers gathered everyday biological materials to look for differences in the absorption of clockwise- or counter-clockwise-rotating radiation in the terahertz spectrum. They studied a maple leaf, a dandelion flower, pork fat and the wing case of an iridescent beetle.

Jul 6, 2019

To cure brain diseases, neuroscientists must collaborate: That’s why I’m giving my data away

Posted by in categories: biotech/medical, neuroscience

Thomas Durcan’s lab is growing 3D mini-brains in the search for a cure for Parkinson’s disease. Over the next year he is giving all his lab’s protocols, methods and results away.

Jul 6, 2019

New approach aids search for genetic roots of complex conditions

Posted by in categories: biotech/medical, genetics, information science, neuroscience

A new method enables researchers to test algorithms for spotting genes that contribute to a complex trait or condition, such as autism.

Researchers often study the genetics of complex traits using genome-wide association studies (GWAS). In these studies, scientists compare the genomes of people who have a condition with those of people without the condition, looking for genetic variants likely to contribute to the condition. These studies often require tens of thousands of people to yield statistically significant results.

GWAS have identified more than 100 genomic regions associated with schizophrenia, for example, and 12 linked to autism. Results are often difficult to interpret, however. Causal variants for a condition may be inherited with nearby sections of DNA that do not play a role.

Jul 6, 2019

More violence as DRC officials report 51 Ebola cases in recent days

Posted by in category: biotech/medical

The Democratic Republic of the Congo (DRC) recorded at least 51 new cases of the Ebola virus since the beginning of the week, while two screening tents in Kasese, a Ugandan village that shares a border with the DRC, were burned after Ugandan workers detected a high fever in a Congolese boy trying to gain entry into Uganda.

Since the outbreak started nearly a year ago in North Kivu and Ituri provinces, DRC, neighboring countries have screened travelers through hundreds of points-of-entry (POE) screening sites.

On Wednesday, officials quoted in a Ugandan newspaper said the fires started after a teenage boy entering Uganda from the DRC tested positive for a high fever and was taken to a hospital in DRC.

Jul 6, 2019

David Sinclair Is Extending Human Lifespan | Rich Roll Podcast

Posted by in categories: biotech/medical, genetics, life extension

David Sinclair PhD is a biologist and Professor of Genetics at Harvard Medical School, co-director of the Paul F. Glenn Center for the Biological Mechanisms of Aging and author of the forthcoming book “Lifespan: The Revolutionary Science of Why We Age — and Why We Don’t Have To”.

This conversation is about the science behind aging and David’s research on the biology of lifespan extension, treating diseases of aging and extending human lifespan.

Continue reading “David Sinclair Is Extending Human Lifespan | Rich Roll Podcast” »

Jul 6, 2019

A drug for treating prostate cancer has been linked with increased risk of dementia, study finds

Posted by in categories: biotech/medical, neuroscience

You don’t improve the body by breaking its parts. In the case of prostate cancer this might be a fair trade-off, but unless you have a specific medical condition that is serious and life-threatening you should not be poisoning yourself with metabolism breaking chemicals. They will have negative impacts all over the body as a rule.

  • Prostate cancer patients who take a hormone-suppressing drug may be at an increased risk for dementia and Alzheimer’s, a study has found.
  • The study of more than 150,000 men found a link between the degenerative diseases and a treatment drug called androgen deprivation therapy.
  • Researchers cautioned doctors to further consider the risks of ADT before giving it to their patients to treat prostate cancer.
  • Visit Business Insider’s homepage for more stories.

A study of more than 150,000 men with prostate cancer found that a certain hormone treatment is linked with increased risks of dementia and Alzheimer’s.

There’s a 20-percent higher chance of having dementia for older men who have taken the prostate cancer treatment, according to the research study from JAMA Network. That drug treatment, called androgen deprivation therapy (ADT), is used to suppress male hormones (like testosterone) that can help to spread prostate cancer in the body.

Continue reading “A drug for treating prostate cancer has been linked with increased risk of dementia, study finds” »

Jul 6, 2019

This spray-on nanofiber ‘skin’ may revolutionize burn and wound care

Posted by in category: biotech/medical

Shaped like a gun, Nanomedic’s SpinCare device emits a web of electrospun polymer nanofabric that stays put for weeks—no dressing changes required.

[Source Photo: Nanomedic Technologies Ltd.]

Jul 6, 2019

Aging is associated with a systemic length-driven transcriptome imbalance

Posted by in categories: biotech/medical, life extension, robotics/AI

Aging manifests itself through a decline in organismal homeostasis and a multitude of cellular and physiological functions. Efforts to identify a common basis for vertebrate aging face many challenges; for example, while there have been documented changes in the expression of many hundreds of mRNAs, the results across tissues and species have been inconsistent. We therefore analyzed age-resolved transcriptomic data from 17 mouse organs and 51 human organs using unsupervised machine learning3 5 to identify the architectural and regulatory characteristics most informative on the differential expression of genes with age. We report a hitherto unknown phenomenon, a systemic age-dependent length-driven transcriptome imbalance that for older organisms disrupts the homeostatic balance between short and long transcript molecules for mice, rats, killifishes, and humans. We also demonstrate that in a mouse model of healthy aging, length-driven transcriptome imbalance correlates with changes in expression of splicing factor proline and glutamine rich (Sfpq), which regulates transcriptional elongation according to gene length. Furthermore, we demonstrate that length-driven transcriptome imbalance can be triggered by environmental hazards and pathogens. Our findings reinforce the picture of aging as a systemic homeostasis breakdown and suggest a promising explanation for why diverse insults affect multiple age-dependent phenotypes in a similar manner.

The transcriptome responds rapidly, selectively, strongly, and reproducibly to a wide variety of molecular and physiological insults experienced by an organism. While the transcripts of thousands of genes have been reported to change with age, the magnitude by which most transcripts change is small in comparison with classical examples of gene regulation2,8 and there is little consensus among different studies. We hence hypothesize that aging is associated with a hitherto uncharacterized process that affects the transcriptome in a systemic manner. We predict that such a process could integrate heterogenous, and molecularly distinctive, environmental insults to promote phenotypic manifestations of aging.

We use an unsupervised machine learning approach3 5 to identify the sources of age-dependent changes in the transcriptome. To this end, we measure and survey the transcriptome of 17 mouse organs from 6 biological replicates at 5 different ages from 4 to 24 months raised under standardized conditions (Fig. 1A). We consider information on the structural architecture of individual genes and transcripts, and knowledge on the binding of regulatory molecules such as transcription factors and microRNAs (miRNAs) (Fig. 1B). We define age-dependent fold-changes as the log2-transformed ratio of transcripts of one gene at a given age relative to the transcripts of that gene in the organs of 4-month-old mice. As expected for models capturing most measurable changes in transcript abundance, the predicted fold-changes (Fig. S1) match changes empirically observed between distinct replicate cohorts of mice (Figs. S2 and S3).

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