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Scientists have discovered your cholesterol levels could be significantly linked to your risk of developing dementia. And itâs not just high cholesterol that matters: fluctuating levels over several years could increase your chances of the disease by 60 per cent, suggests a new study of 10,000 people.
The research also suggests that, even if you donât develop dementia, a large cholesterol variability â swinging from high to low levels â is linked to an increased risk of general cognitive decline by 23 per cent.
Summary: Scientists have reprogrammed mouse cells into pluripotent stem cells using a gene from choanoflagellates, single-celled organisms related to animals. This breakthrough demonstrates that key genes driving stem cell formation existed in unicellular ancestors nearly a billion years ago.
The resulting stem cells were used to create a chimeric mouse, showcasing how ancient genetic tools can integrate with modern mammalian biology. This discovery redefines the evolutionary origins of stem cells and may inform regenerative medicine advancements.
Minuscule particles of plastic are not only bad for the environment. A study led from UmeÄ University, Sweden, has shown that the so-called nanoplastics which enter the body also can impair the effect of antibiotic treatment. The results also indicate that the nanoplastics may lead to the development of antibiotic resistance. Even the indoor air in our homes contains high levels of nanoplastics from, among other things, nylon, which is particularly problematic.
âThe results are alarming considering how common nanoplastics are and because effective antibiotics for many can be the difference between life and death,â says Lukas Kenner, professor at the Department of Molecular Biology at UmeĂ„ University and one of the researchers who led the study.
Nanoplastics are plastic particles that are smaller than a thousandth of a millimetre. Due to their smallness, they can float freely in the air and have the ability to enter the body.
Despite being a mature technology in existence for over several decades, silicon photonic modulators face scrutiny from industry and academic experts. In a recent editorial interview, experts emphasize the need to explore alternatives beyond the traditional platforms. The discussion centers on innovative modulator materials and configurations that could cater to emerging applications in data centers, artificial intelligence, quantum information processing, and LIDAR. Experts also outline the challenges that lie ahead in this field.
Optical and photonic modulators are technologically advanced devices that enable the manipulation of light propertiesâsuch as power and phaseâbased on input signals. Over the decades, scientists have researched and developed silicon photonic modulators with wide-ranging applications, including optical data communication, sensing, biomedical technologies, automotive systems, astronomy, aerospace, and artificial intelligence (AI).
However, these modulators face bandwidth limitations and operational robustness issues stemming from the fundamental properties of silicon and other practical constraints, as highlighted by a panel of leading industry and academic experts in a recent editorial interview.
Can weight loss leave a lasting imprint on our fat cells?
Losing weight is often touted as a cornerstone of better health, particularly for people dealing with obesity and its associated health risks.
Anyone who has ever tried to get rid of a few extra kilos knows the frustration: the weight drops initially, only to be back within a matter of weeksâthe yo-yo effect has struck. Researchers at ETH Zurich have now been able to show that this is all down to epigenetics.
Using data and samples from volunteers, including Kaiser Permanente Washington members participating in the Adult Changes in Thought Study (ACT Study), the researchers used advanced genomic technologies and machine learning models to create a timeline of the cellular and molecular changes caused byâŠ
Mapping the disease at the cellular level identifies possible new treatment targets.
Researchers in the Nanoscience Center at the University of JyvÀskylÀ, Finland, have used machine learning and supercomputer simulations to investigate how tiny gold nanoparticles bind to blood proteins. The studies discovered that favorable nanoparticle-protein interactions can be predicted from machine learning models that are trained from atom-scale molecular dynamics simulations. The new methodology opens ways to simulate the efficacy of gold nanoparticles as targeted drug delivery systems in precision nanomedicine.
Hybrid nanostructures between biomolecules and inorganic nanomaterials constitute a largely unexplored field of research, with the potential for novel applications in bioimaging, biosensing, and nanomedicine. Developing such applications relies critically on understanding the dynamical properties of the nanoâbio interface.
Modeling the properties of the nano-bio interface is demanding since the important processes such as electronic charge transfer, chemical reactions or restructuring of the biomolecule surface can take place in a wide range of length and time scales, and the atomistic simulations need to be run in the appropriate aqueous environment.
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The book âIntelciety. Intelligent Society. Are We Ready for the Challenge?â explores the profound changes that artificial intelligence (AI) and other emerging technologies are causing in modern society. Vicente Ferreira da Silva addresses how these technologies are transforming various fields, from medicine and biotechnology to robotics and nanotechnology, and questions whether we are truly prepared to deal with these advances.
While investigating a rare developmental disorder, researchers ended up discovering a spectrum of conditions that are all linked to one gene.
