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Category: nanotechnology

Steering brain cells with magnetic nanoparticles to rebuild lost connections

A collaborative study led by Professor Vittoria Raffa at the University of Pisa and Assistant Professor Fabian Raudzus (Department of Clinical Application) has unveiled a novel approach that uses magnetically guided mechanical forces to direct axonal growth, aiming to enhance the effectiveness of stem cell-based therapies for Parkinson’s disease (PD) and other neurological conditions.

Parkinson’s disease is characterized by the progressive degeneration of dopaminergic neurons in the (SN), which project to the striatum (ST) via the nigrostriatal pathway. The loss of these connections leads to dopamine deficiency and the onset of motor symptoms.

While cell replacement therapies using human stem cell-derived dopaminergic progenitors have shown encouraging results in , a key limitation remains: the inability to guide the axons of transplanted cells over long distances to their appropriate targets in the adult brain.

Why Different Neuron Parts Learn Differently?

To try everything Brilliant has to offer—free—for a full 30 days, visit https://brilliant.org/ArtemKirsanov. You’ll also get 20% off an annual premium subscription.

Socials:
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My name is Artem, I’m a graduate student at NYU Center for Neural Science and researcher at Flatiron Institute. In this video we explore a recent study published in Science, which revealed that different compartments of pyramidal neurons (apical vs basal dendrites) use different plasticity rules for learning.

Link to the paper:
https://www.science.org/doi/10.1126/science.ads4706

Outline:
00:00 Introduction.
01:23 Synaptic transmission.
06:09 Molecular machinery of LTP
08:40 Hebbian plasticity.
11:21 Non-Hebbian plasticity.
12:51 Hypothesis.
14:42 Experimental methods.
17:10 Result: compartmentalized plasticity.
19:30 Interpretation.
22:01 Brilliant.
23:08 Outro.

Music by Artlist.

Continue reading “Why Different Neuron Parts Learn Differently?” | >

DNA Nanotubule‐Based Nanodevices with ATP‐Responsive Gating for Direct Cytosolic Delivery of Nucleic Acids and Proteins

Schematic illustration of two pathways for macromolecular therapeutics delivery: nanoparticle-adopted endocytosis (left) and DNA nanotubule-mediated cytosolic delivery (right). By bypassing conventio…

Robotic eyes mimic human vision for superfast response to extreme lighting

In blinding bright light or pitch-black dark, our eyes can adjust to extreme lighting conditions within a few minutes. The human vision system, including the eyes, neurons, and brain, can also learn and memorize settings to adapt faster the next time we encounter similar lighting challenges.

In an article published in Applied Physics Letters, researchers at Fuzhou University in China created a machine vision sensor that uses quantum dots to adapt to extreme changes in light far faster than the human eye can—in about 40 seconds—by mimicking eyes’ key behaviors. Their results could be a game changer for robotic vision and autonomous vehicle safety.

“Quantum dots are nano-sized semiconductors that efficiently convert light to ,” said author Yun Ye.

Manipulation of light at the nanoscale helps advance biosensing

Traditional medical tests often require clinical samples to be sent off-site for analysis in a time-intensive and expensive process. Point-of-care diagnostics are instead low-cost, easy-to-use, and rapid tests performed at the site of patient care. Recently, researchers at the Carl R. Woese Institute for Genomic Biology reported new and optimized techniques to develop better biosensors for the early detection of disease biomarkers.

People have long been fascinated with the iridescence of peacock feathers, appearing to change color as light hits them from different angles. With no pigments present in the feathers, these colors are a result of light interactions with nanoscopic structures, called photonic crystals, patterned across the surface of the feathers.

Inspired by biology, scientists have harnessed the power of these photonic crystals for biosensing technologies due to their ability to manipulate how light is absorbed and reflected. Because their properties are a result of their nanostructure, photonic crystals can be precisely engineered for different purposes.

Engineering nano-clouds that can change color, temperature and outwit heat sensors

How does a cloud stay cool under direct sunlight––or seem to vanish in infrared? In nature, phenomena like white cumulus clouds, gray storm systems, and even the hollow hairs of polar bears offer remarkable lessons in balancing temperature, color and invisibility. Inspired by these atmospheric marvels, researchers have now created a nanoscale “cloud” metasurface capable of dynamically switching between white and gray states—cooling or heating on demand––all while evading thermal detection.

How a common herpes virus evades the immune system: Study tackles a leading cause of birth defects

New research from the University of Pittsburgh School of Medicine and La Jolla Institute for Immunology, published today in Nature Microbiology, reveals an opportunity for developing a therapy against cytomegalovirus (CMV), the leading infectious cause of birth defects in the United States.

Researchers discovered a previously unappreciated mechanism by which CMV, a that infects the majority of the world’s adult population, enters cells that line the blood vessels and contributes to vascular disease. In addition to using molecular machinery that is shared by all herpes viruses, CMV employs another molecular “key” that allows the virus to sneak through a side door and evade the body’s natural immune defenses.

The finding might explain why efforts to develop prophylactic treatments against CMV have, so far, been unsuccessful. This research also highlights a new potential avenue for the development of future and suggests that other viruses of the herpes family, such as Epstein-Barr and chickenpox, could use similar molecular structures to spread from one infected cell to the next while avoiding immune detection.