Lifeboat Foundation

Increases in life span are one of the greatest success stories of modern society. Yet, while most of us can expect to live longer, we are spending more years in ill health. Reducing this period of ill health at the end of life is the main aim of a group of scientists known as biogerontologists.

By studying aging in animals, including fruit flies, worms, and rodents, biogerontologists have identified biological phenomena involved with aging that all these organisms share. And some of these biological processes may also regulate aging in humans.

Scientists attempting to understand and improve the aging process have identified many molecules that appear to improve aging in these animals (although evidence in humans remains scant). These molecules include compounds found in grapes, apples, and even bacteria.

Due to a lack of fossil records, the early evolution of snakes has been a mystery, until now. Paleontologists have discovered new fossils of the prehistoric legged snake, Najash that has helped solve the mystery of how this creepy-crawly evolved into the slithering reptile it is today.

Researchers have examined the fossils of Najash rionegrina, a rear-limbed snake from the Late Cretaceous period. it has been named after the Biblical legged snake, Nahash, who tempted Eve and Adam to eat the forbidden fruit in the Book of Genesis. Found in Patagonia, Argentina, the fossil has revealed that snakes not only had limbs 100 million years ago but also had cheekbones (jugal bone).

The study published in Science Advances reveals how snakes evolved from their lizard ancestors. Fernando Garberoglio from the Fundación Azara at Universidad Maimónides, Buenos Aires explained, “Our findings support the idea that the ancestors of modern snakes were big-bodied and big-mouthed—instead of small burrowing forms as previously thought.”

Chronic sleep loss could be linked to one sign of premature aging in the body, according to a new study published in Communications Biology. Using fitness tracker data, researchers showed that consumer sleep trackers can shine a light on the high costs of not getting enough sleep.

Growing evidence from mouse studies suggests that a healthy microbiome might improve poststroke outcomes.

Physicists use two types of measurements to calculate the expansion rate of the universe, but their results do not coincide, which may make it necessary to update the cosmological model. “It’s like trying to thread a cosmic needle,” explains researcher Licia Verde of the University of Barcelona, co-author of an article on the implications of this problem.

More than a hundred scientists met this summer at the Kavli Institute for Theoretical Physics at the University of California (U.S.) to try to clarify what is happening with the discordant data on the expansion rate of the universe, an issue that affects the very origin, evolution and fate of our cosmos. Their conclusions have been published in Nature Astronomy journal.

“The problem lies in the Hubble constant (H0), a parameter which value—it is actually not a constant because it changes with time—indicates how fast the Universe is currently expanding,” points out cosmologist Licia Verde, an ICREA researcher at the Institute of Cosmos Sciences of the University of Barcelona (ICC-UB) and the main author of the article.

The evolution of human diets led to preferences toward polyunsaturated fatty acid (PUFA) content with ‘Western’ diets enriched in ω-6 PUFAs. Mounting evidence points to ω-6 PUFA excess limiting metabolic and cognitive processes that define longevity in humans. When chosen during pregnancy, ω-6 PUFA-enriched ‘Western’ diets can reprogram maternal bodily metabolism with maternal nutrient supply precipitating the body-wide imprinting of molecular and cellular adaptations at the level of long-range intercellular signaling networks in the unborn fetus. Even though unfavorable neurological outcomes are amongst the most common complications of intrauterine ω-6 PUFA excess, cellular underpinnings of life-long modifications to brain architecture remain unknown. Here, we show that nutritional ω-6 PUFA-derived endocannabinoids desensitize CB1 cannabinoid receptors, thus inducing epigenetic repression of transcriptional regulatory networks controlling neuronal differentiation. We found that cortical neurons lose their positional identity and axonal selectivity when mouse fetuses are exposed to excess ω-6 PUFAs in utero. Conversion of ω-6 PUFAs into endocannabinoids disrupted the temporal precision of signaling at neuronal CB1 cannabinoid receptors, chiefly deregulating Stat3-dependent transcriptional cascades otherwise required to execute neuronal differentiation programs. Global proteomics identified the immunoglobulin family of cell adhesion molecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling uncovering epigenetic reprogramming at 1400 sites in neurons after prolonged cannabinoid exposure. We found anxiety and depression-like behavioral traits to manifest in adult offspring, which is consistent with genetic models of reduced IgCAM expression, to suggest causality for cortical wiring defects. Overall, our data uncover a regulatory mechanism whose disruption by maternal food choices could limit an offspring’s brain function for life.

• Immediate Communication
• Published: 18 November 2019

• Valentina Cinquina ¹,
• Daniela Calvigioni ¹,
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Artificial muscles will power the soft robots and wearable devices of the future. But more needs to be understood about the underlying mechanics of these powerful structures in order to design and build new devices.

Now, researchers from the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have uncovered some of the fundamental physical properties of artificial muscle fibers.

“Thin soft filaments that can easily stretch, bend, twist or shear are capable of extreme deformations that lead to knot-like, braid-like or loop-like structures that can store or release energy easily,” said L. Mahadevan, the Lola England de Valpine Professor of Applied Mathematics, of Organismic and Evolutionary Biology, and of Physics. “This has been exploited by a number of experimental groups recently to create prototypical artificial muscle fibers. But how the topology, geometry and mechanics of these slender fibers come together during this process was not completely clear. Our study explains the theoretical principles underlying these shape transformations, and sheds light on the underlying design principles.”

Is it accurate?

Does it really show your so-called “biological vs. chronological” age?

And once you do get your results, how can you lengthen your telomeres?

Researchers from the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, Institute of Molecular and Clinical Ophthalmology Basel, and ETH Zurich, Switzerland, have presented new insights into the development of the human brain and differences in this process compared to other great apes. The study reveals features of brain development that are unique to humans, and outlines how these processes have diverged from those in other primates.

Since humans diverged from a common ancestor shared with chimpanzees and the other great apes, the human brain has changed dramatically. However, the genetic and developmental processes responsible for this divergence are not understood. Cerebral organoids (brain-like tissues), grown from stem cells in a dish, offer the possibility to study the evolution of early brain development in the laboratory.

Sabina Kanton, Michael James Boyle and Zhisong He, co-first authors of the study, together with Gray Camp, Barbara Treutlein and colleagues analyzed human cerebral organoids through their development from stem cells to explore the dynamics of gene expression and regulation using methods called single-cell RNA-seq and ATAC-seq. The authors also examined chimpanzee and macaque cerebral organoids to understand how organoid development differs in humans.