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Was William James Right About Consciousness?

Dr. Nicolas Rouleau is a neuroscientist, bioengineer, and Assistant Professor of Health Sciences at Wilfrid Laurier University. He wrote the award-winning essay, ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death,’ in which he argues that the transmissive theory of consciousness may actually be more consistent with emerging scientific insights than the dominant assumption that the brain generates consciousness.

In this conversation with Hans Busstra, Rouleau shares the main arguments from his essay, which touch upon his collaboration with Dr. Michael Persinger, the inventor of the ‘God Helmet,’ and his work with Michael Levin on ‘mind blindness’—the idea that science may be searching for mind in too restricted a place by focusing almost exclusively on neurons.

More information on Dr. Nic Rouleau:
https://www.wlu.ca/academics/facultie… website: https://www.rouleaulab.com/ Further reading and scientific references discussed in this video: Rouleau’s BICS Essay: ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death.’ https://www.bigelowinstitute.org/inde… Rouleau, N., Levin, M., et al. (2025) (Preprint; forthcoming in Philosophical Transactions of the Royal Society). Brains and Where Else? Mapping Theories of Consciousness to Unconventional Embodiments. https://tinyurl.com/439rrn8z Rouleau, N., & Levin, M. (2023). The Multiple Realizability of Sentience in Living Systems and Beyond. eNeuro, 10(11). https://tinyurl.com/2s4bdtmm Rouleau, N. & Cimino, N. (2022). A Transmissive Theory of Brain Function: Implications for Health, Disease, and Consciousness. NeuroSci, 3. https://www.mdpi.com/2673-4087/3/3/32 McCraty, R., et al. (2018). Long-term study of heart rate variability responses to changes in the solar and geomagnetic environment. https://tinyurl.com/254x3b9t Rouleau, N., & Persinger, M. A. (2016). Differential responsiveness of the right parahippocampal region to electrical stimulation in fixed human brains: Implications for historical surgical stimulation studies. Epilepsy & Behavior, 60181–186. https://tinyurl.com/uc5jbr Rajaram, M., & Mitra, S. (1981). Correlation between convulsive seizure and geomagnetic activity. Neuroscience Letters, 24, 187–191. https://tinyurl.com/3snrs4cs Chapters 0:00 Introduction 4:00 What Nic Rouleau would say to William James about his theory of transmissive consciousness 7:14 What do we know empirically about how electromagnetic fields influence our brains? 10:27 How scientifically rigorous are the empirical data on the influence of the Earth’s magnetic field on brains? 11:35 On Nic’s mentor, Dr. Michael Persinger, the inventor of the God Helmet 14:42 Research on post-mortem brain tissue 18:09 What mental states are influenced by magnetic fields? 18:58 Electromagnetic effects in dead vs. living brains 19:45 On Michael Levin and the paradigm shift due to bioelectricity 21:24 Influencing the thoughts of deceased people 25:33 Are biological forms stored in the Earth’s magnetic field? 30:21 Shielding brains from electromagnetic fields 33:12 Mind blindness: we only see 1% of the minds out there 38:55 What is the best way out of mind blindness? 41:06 Plant-based computation 42:00 The Self-Organizing Units Lab (SOUL) and what Nic is working on 43:23 Minds in a Petri dish 46:13 What counts as embodiment? 48:44 Phenomenal consciousness on different levels 53:06 What theories of consciousness can get us out of the behaviorist trap? 57:25 Nic’s award-winning essay on consciousness beyond death 1:00:55 Intermediary states of consciousness, the Bardo Thodol 1:04:46 Consciousness when the radio, the brain, is completely broken 1:06:35 Why exactly is electromagnetism a better explanation of consciousness beyond death than NDEs or OBEs? 1:11:58 How does the God Helmet work? 1:17:31 Which electromagnetic fields influence our consciousness and which ones don’t? 1:23:59 Can all of consciousness be stored in the Earth’s magnetic field? 1:27:08 Children with past-life memories: could electromagnetism play a role there? 1:29:51 How do quantum theories of consciousness relate to the work of Nic? 1:33:42 Do our brains connect electromagnetically with each other? 1:35:28 Nic on the hard problem of consciousness 1:38:00 Aren’t you just a materialist 2.0? 1:40:25 On the meaning of Nic’s work Copyright © 2026 Essentia Foundation. All rights on interview content reserved.
Personal website: https://www.rouleaulab.com/

Further reading and scientific references discussed in this video:

Rouleau’s BICS Essay: ‘An Immortal Stream of Consciousness: The scientific evidence for the survival of consciousness after permanent bodily death.’ https://www.bigelowinstitute.org/inde…

Rouleau, N., Levin, M., et al. (2025) (Preprint; forthcoming in Philosophical Transactions of the Royal Society). Brains and Where Else? Mapping Theories of Consciousness to Unconventional Embodiments. https://tinyurl.com/439rrn8z.

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CRISPR the emergence of TIGR systems Rewriting DNA

Delve into the groundbreaking world of CRISPR gene editing – a technology rapidly reshaping medicine and offering unprecedented hope for treating previously incurable diseases. This video explores the remarkable journey from basic scientific curiosity about bacterial defense mechanisms to the first-ever personalized gene therapies being administered in Germany and beyond.

Discover how scientists uncovered CRISPR, an ancient bacterial immune system that functions as a precise molecular “cut-and-paste” tool for DNA. Learn about the astonishing speed at which this discovery transitioned from laboratory research to clinical applications, culminating in FDA approval of treatments for sickle cell disease and beta thalassemia – conditions once considered devastatingly difficult to manage.

We’ll examine the details of these revolutionary therapies, including how they work to correct genetic defects and provide lasting relief for patients. Beyond current successes, explore the exciting potential of CRISPR to address a wide range of inherited disorders, from hereditary angioedema to various cancers.

The video highlights the extraordinary case of KJ, an infant who received a custom-designed CRISPR base editing therapy to treat a rare metabolic disorder – demonstrating the feasibility of truly personalized medicine tailored to individual genetic profiles. Understand how this breakthrough compresses years of research into mere months, paving the way for treating countless other rare diseases.

Finally, look ahead to the future with the emergence of TIGR systems, an even more advanced class of gene-editing tools discovered in viruses that infect bacteria. These next-generation technologies promise enhanced precision, broader targeting capabilities, and potentially safer therapeutic applications. Join us as we unpack this complex science and reveal how fundamental research continues to unlock the secrets of life and offer hope for a healthier future.

#genetherapy.

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Light-Directed Evolution of More Complex Proteins

Researchers have discovered how to guide the evolution of proteins with light to develop more complex proteins, paving the way for new possibilities in synthetic biology and biotechnology.

Read the OPN story: biotech technology physics.

New technique creates new possibilities for synthetic biology and biotechnology.

New cellular immunotherapy approach for Alzheimer’s disease

Alzheimer’s disease starts with a sticky protein called amyloid beta that builds up into plaques in the brain, setting off a chain of events that results in brain atrophy and cognitive decline. Microglia, immune cells that reside in the brain, are responsible for removing brain waste but can become dysfunctional when overwhelmed in the context of neurodegenerative disease.

To reduce the cleaning burden on microglia, first author transformed astrocytes, the most abundant cell type in the brain, into amyloid-cleaning machines. The author custom-designed and delivered a gene to astrocytes that codes for the chimeric antigen receptor (CAR) via a harmless virus injected into mice. The CAR, now present on the surface of astrocytes, enabled the cells to capture and engulf amyloid beta proteins. With their newly acquired ability, the astrocytes — generally responsible for keeping the brain tidy — concentrated their efforts on only cleaning amyloid beta plaques in mice prone to its buildup.

Mice carrying genetic mutations that increase people’s risk of developing Alzheimer’s disease develop amyloid beta plaques that saturate the brain by six months of age. The author injected two groups of mice with the virus carrying the CAR-expressing gene: young mice before they developed plaques and older mice with brains saturated with plaques, then, waited three months.

As the younger mice aged, the CAR-astrocytes prevented amyloid beta plaque development. At nearly six months of age, when untreated mice normally have brains saturated with harmful plaques, brains of treated mice were plaque-free. Meanwhile, older mice with plaque-saturated brains at the time of treatment saw a 50% reduction in the amount of amyloid beta plaques compared to mice receiving an injection of a virus lacking the CAR gene.

The researchers have filed a patent related to the approach used to engineer CAR-astrocytes.

“Consistent with the antibody drug treatments, this new CAR-astrocyte immunotherapy is more effective when given in the earlier stages of the disease,” said a co-author on the paper. “But where it differs, and where it could make a difference in clinical care, is in the single injection that successfully reduced the amount of harmful brain proteins in mice.” ScienceMission sciencenewshighlights.

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Mining the dark transcriptome: Synthesizing the first potential drug molecules from long noncoding RNA

A team from University of Toronto Engineering is the first to synthesize long noncoding RNA (lncRNA) outside the cell—a new approach to drug discovery that has already yielded some promising anti-inflammatory molecules. The team was inspired by advances in the field of messenger RNA (mRNA) and protein replacement therapies. They realized that a similar approach could be used to deliver lncRNA to the body, unlocking a potential new source of drugs.

“Only about 25% of our DNA encodes for proteins, including everything from insulin for regulating blood sugar to antibodies for immune defense,” says Professor Omar F. Khan, senior author on a paper published in Science Signaling that describes the new discovery.

“Proteins are made via messenger RNA, or mRNA, which conveys the instructions for how to build proteins from our genes to our ribosomes, the part of our cells where proteins are assembled.”

Cryogenic Arks — Sleeping Through the Ages

From frozen habitats to millennia-long journeys, we explore the science behind cryogenic arks and deep-time interstellar travel.

Get Nebula using my link for 50% off an annual subscription: https://go.nebula.tv/isaacarthur.
Check out Joe Scott’s Oldest & Newest: https://nebula.tv/videos/joescott-old… my exclusive video Chronoengineering: https://nebula.tv/videos/isaacarthur–… 🚀 Join this channel to get access to perks: / @isaacarthursfia 🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall… 🌐 Visit our Website: http://www.isaacarthur.net ❤️ Support us on Patreon: / isaacarthur ⭐ Support us on Subscribestar: https://www.subscribestar.com/isaac-a… 👥 Facebook Group: / 1,583,992,725,237,264 📣 Reddit Community: / isaacarthur 🐦 Follow on Twitter / X: / isaac_a_arthur 💬 SFIA Discord Server: / discord Credits: Cryogenic Arks – Sleeping Through the Ages Written, Produced & Narrated by: Isaac Arthur Select imagery/video supplied by Getty Images Music by Epidemic Sound: http://nebula.tv/epidemic & Stellardrone Chapters 0:00 Intro 2:50 The Need for Cryogenic Arks 6:12 From Freezing Flesh to Preserving Life 12:33 The Physics and Engineering of the Cryogenic Ark 18:46 The Problem of Time and Identity 24:59 Oldest & Newest 25:59 How Long Can We Stay Frozen? 30:48 Crew Dynamics and Risk 35:18 Beyond Cryogenics – Slowing Time Itself.
Watch my exclusive video Chronoengineering: https://nebula.tv/videos/isaacarthur–…

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🛒 SFIA Merchandise: https://isaac-arthur-shop.fourthwall…
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Light-guided ‘optovolution’ evolves proteins that switch states on schedule

EPFL researchers have developed a light-based method that can produce proteins that switch states, respond to signals, and even compute, using light and the cell cycle.

Evolution is biology’s powerful method of engineering. It works by generating many variants of DNA, RNA, and proteins inside cells and letting nature “select” the organism that performs best. Early farmers started taking advantage of evolution by interfering with natural selection and letting only the most productive livestock and crops mate.

In laboratories, researchers have developed methods for directed evolution of proteins, especially enzymes and antibodies, that are used in household detergents, medicine, and industry.

MARK2 serves as a key regulator of host antiviral immunity through GEF-H1 phosphorylation

Key cytoplasmic sensors, including the RNA sensors RIG-I and melanoma differentiation-associated gene 5 (MDA5), along with the DNA sensor cyclic GMP-AMP synthase (cGAS), specifically recognize viral RNA and DNA.6,7 Upon nucleic acid detection, PRR adaptors (TRIF, MAVS, and STING) recruit kinases such as TBK1 and IKKε to initiate downstream signaling cascades.8,9,10 This process leads to the phosphorylation and activation of the transcription factor interferon regulatory factor 3 (IRF3), which subsequently translocates from the cytoplasm to the nucleus to trigger type I interferon (IFN-I; IFN-α/β) expression.11,12,13 The secreted IFNs then activate pathways that culminate in the expression of interferon-stimulated genes (ISGs), establishing an antiviral state in host cells.13

Guanine nucleotide exchange factor H1 (GEF-H1), encoded by Arhgef2, is a microtubule-associated protein (MAP) and plays a pivotal role in diverse cellular processes, including epithelial barrier permeability, cell cycle regulation, cell motility, polarization, and leukemic cell differentiation.14 Beyond its structural role, GEF-H1 contributes to inflammatory cytokine production, intracellular mycobacterial elimination, and macrophage-mediated antiviral defenses.15,16 Activation of GEF-H1 enhances RLR signaling through its interaction with TBK1, thereby promoting IFN-β induction in macrophages via a microtubule-dependent mechanism.15 Its regulation also extends beyond microtubule binding and involves phosphorylation-dependent mechanisms and dynamic protein-protein interactions.17,18,19,20,21,22,23 The RhoA-specific GEF activity of GEF-H1 is inhibited by its phosphorylation at Ser886 and Ser959, which is mediated by microtubule affinity-regulating kinase 2 (MARK2).24 Notably, here, MARK2 was also screened out to interact with GEF-H1 by immunoprecipitation and mass spectrometry (IP-MS) assays in A549 cells. MARK2 belongs to the evolutionarily conserved KIN1/PAR-1/MARK family of serine/threonine kinases, which are crucial for microtubule stability and cellular polarity from yeast to humans.25 All mammalian MARK family members (MARK1–4) share a conserved architecture, featuring an N-terminal catalytic domain, a central ubiquitin-associated domain, and a C-terminal kinase-associated domain.26,27 These kinases regulate microtubule dynamics by phosphorylating key MAPs, including TAU, MAP2, and MAP4.28,29 However, their roles in viral infections remain poorly understood.30

Given the importance of phosphorylation-dependent signaling in antiviral responses, we hypothesized that MARK2 may modulate innate immunity through interacting with GEF-H1. To test this, we employed a combination of in vitro and in vivo approaches, including MS-based interactome profiling, reporter gene assays, gene editing via CRISPR-Cas9, in vitro kinase assays, viral infection models in primary macrophages and cell lines, and mouse models of RNA and DNA virus infection. By elucidating the functional significance of the MARK2-GEF-H1-TBK1 signaling axis, this study aims to reveal a previously uncharacterized layer of innate immune regulation and identify potential targets for broad-spectrum antiviral strategies.

Smart fluorescent molecules provide cheaper path to sharper microscopy images

Multiphoton microscopy is used in biomedical research to study cells and tissues. Today, so-called two-photon microscopy is used to study processes within cells, but the technique has limitations in terms of image resolution. Four-photon microscopy provides images with higher resolution. However, such instruments are very expensive and, when studying biological material, the powerful laser light required can damage samples.

“In this project, we have developed molecules to visualize molecular-level details and monitor processes using the more common two-photon microscopy technique. These molecules have the capacity to achieve higher resolution than with four-photon microscopy, although two-photon microscopy is used,” says the project coordinator Joakim Andréasson, Professor at the Department of Chemistry and Chemical Engineering at Chalmers University of Technology.

“In the long term, results from studies of this kind may provide new insights into diseases, pharmaceuticals and the very smallest building blocks of life.”

A rewritable DNA hard drive may help solve the growing data storage crisis

Around the world, scientists are exploring an unexpected solution to the growing data crisis: storing digital information in synthetic DNA. The idea is simple but powerful—DNA is one of the most compact, durable information systems on Earth. But one issue has held the field back. Once data is written into DNA, it can’t be changed.

Now, researchers at the University of Missouri are helping to solve that problem by transforming DNA from a one-time medium into a rewritable digital hard drive. Their research is published in the journal PNAS Nexus.

“DNA is incredible—it stores life’s blueprint in a tiny, stable package,” said Li-Qun “Andrew” Gu, a professor of chemical and biomedical engineering at Mizzou’s College of Engineering. “We wanted to see if we could store and rewrite information at the molecular level faster, simpler and more efficiently than ever before.”

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