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Category: chemistry

Computationally accelerated organic synthesis: Optimal ligand prediction for generating reactive alkyl ketone radicals

Because ketones are widespread in organic molecules, chemists are eager to develop new reactions that use them to form chemical bonds. One challenging reaction is the one-electron reduction of ketones to generate ketyl radicals.

Ketyl radicals are reactive intermediates used in natural product synthesis and pharmaceutical chemistry; however, most methodologies are optimized for aryl while simple alkyl ketones remain challenging for chemists. Alkyl ketones are considerably more abundant but intrinsically more difficult to reduce than aryl ketones.

To this end, a team of specialized organic chemists and computational chemists from WPI-ICReDD at Hokkaido University has developed a new catalytic method for generating alkyl ketyl radicals.

JWST Detects Carbon-Rich Disk Around Young Exoplanet

“We want to learn more about how our solar system formed moons. This means that we need to look at other systems that are still under construction. We’re trying to understand how it all works,” said Dr. Gabriela Cugno.

How do moons form around gas giant planets? This is what a recent study published in The Astrophysical Journal Letters hopes to address as a team of scientists investigated how circumplanetary disks (CPDs) comprised of the gas and dust leftover from planetary formation evolve into moons. This study has the potential to help scientists better understand the conditions for exomoon formation and evolution and where scientists could potentially search for life beyond Earth.

For the study, the researchers used NASA’s James Webb Space Telescope to observe the CPD orbiting CT Cha b, which is located approximately 620 light-years from Earth and is approximately 17 times as massive as Jupiter. The goal of the study was to ascertain the composition of the CPD and compare it to CT Cha b and the surrounding disk of the host star, CT Cha A.

In the end, the researchers found that the CPD around CT Cha b was composed of carbon-rich chemistry that contrasted compositions of gas giant exoplanet atmospheres. Additionally, the researchers found the CPD’s carbon-rich chemistry composition also contrasted with the disk surrounding CT Cha A. The team concluded that this is the first evidence of moon formation around a gas giant exoplanet and compared this to the potential formation mechanism for Jupiter’s Galilean moons.

Astronomers Create First 3D Map of an Exoplanet’s Atmosphere

“Eclipse mapping allows us to image exoplanets that we can’t see directly, because their host stars are too bright,” said Dr. Ryan Challener.

What can a 3D map of an exoplanet’s atmosphere teach astronomers about the planet’s formation, evolution, and composition? This is what a recent study published in Nature Astronomy hopes to address as a team of scientists presented a first-time 3D map of an exoplanet’s atmosphere based on temperature. This study has the potential to help scientists better understand the formation and evolution of exoplanet atmospheres while opening the doors for developing better methods of studying them.

For the study, the researchers used data obtained from NASA’s James Webb Space Telescope to develop a new method called 3D eclipse mapping on WASP-18b, which is located just over 400 light-years from Earth and whose radius is slightly more than Jupiter’s while have ten times its mass. WASP-18b is known as an “ultra-hot” Jupiter, as it orbits extremely close to its star at 0.02024 astronomical units (AU) while completing one orbit in only 0.9 days. For context, the planet Mercury orbits our Sun at 0.387 AU and completes one orbit in 88 days. WASP-18b is also tidally locked to its star like our Moon is tidally locked to Earth.

In the end, the researchers found that WASP-18b’s “dayside” features variations in temperature and chemical composition while also exhibiting a circular “hotspot” where the largest amount of starlight hits the atmosphere. Additionally, the team found this hotspot is surrounded by a colder “ring” closer to the limbs of the planet, or the outer edges where the shape of the planet is visible.

Powerful New Antibiotic Was ‘Hiding in Plain Sight’ For Decades

Researchers have just identified a powerful new antibiotic – in a significant discovery made not by breaking new ground, but by revisiting familiar territory.

The compound, pre-methylenomycin C lactone, was discovered by a team from Warwick University in the UK and Monash University in Australia. While it’s never been spotted before, it comes from a type of bacteria that scientists have studied for decades.

Potentially, it could help fight bacteria that have become increasingly resistant to modern treatments – and it’s actually an intermediate chemical that’s created during the process of making another antibiotic, methylenomycin A.

Chemists design candidate drug against diabetes

Researchers from the University at Albany and NYU Grossman School of Medicine have found a way to block a key cellular pathway known to drive chronic inflammation and impaired wound healing in people with diabetes.

The breakthrough could offer a new therapeutic option for stopping the harmful effects of both type 1 and type 2 at the source.

In their latest work, the researchers successfully identified—and developed a small molecule drug to disrupt—an intracellular chain reaction that is a major contributor to diabetes-induced complications. Their findings, published earlier this month, were featured on the cover of Cell Chemical Biology.

Lignin increases the stability and effectiveness of herbicide nanoparticles, study shows

A recent study has shown that a fraction obtained from lignin, an organic polymer responsible for the rigidity of plant cell walls, was able to improve the performance of nanoparticles with herbicide.

The work is published in the journal ACS Sustainable Chemistry & Engineering and was recently featured on its cover.

The study was conducted by researchers from three research institutions in the state of São Paulo, Brazil: São Paulo State University (UNESP), the State University of Campinas (UNICAMP), and the Federal University of São Carlos (UFSCar).

Artificial neurons replicate biological function for improved computer chips

Researchers at the USC Viterbi School of Engineering and School of Advanced Computing have developed artificial neurons that replicate the complex electrochemical behavior of biological brain cells.

The innovation, documented in Nature Electronics, is a leap forward in neuromorphic computing technology. The innovation will allow for a reduction of the chip size by orders of magnitude, will reduce its energy consumption by orders of magnitude, and could advance artificial general intelligence.

Unlike conventional digital processors or existing neuromorphic chips based on silicon technology that merely simulate neural activity, these physically embody or emulate the analog dynamics of their biological counterparts. Just as neurochemicals initiate brain activity, chemicals can be used to initiate computation in neuromorphic (brain-inspired) . By being a physical replication of the biological process, they differ from prior iterations of artificial neurons that were solely mathematical equations.

This Wonder Material Could Revolutionize Renewable Energy

A team of researchers has explored how two-dimensional materials known as MXenes could revolutionize renewable energy and sustainable chemical production. Scientists searching for cleaner and more sustainable technologies are turning their attention to two-dimensional materials that could transfo

Machine learning enables real-time analysis of iron oxide thin film growth in reactive magnetron sputtering

Researchers at University of Tsukuba have developed a technology for real-time estimation of the valence state and growth rate of iron oxide thin films during their formation. This novel technology was realized by analyzing the full-wavelength data of plasma emission spectra generated during reactive sputtering using machine learning. It is expected to enable high-precision control of the film deposition process.

Metal oxide and nitride thin films are commonly used in and energy materials. Reactive sputtering is a versatile technique for depositing thin films by reacting a target metal with gases such as oxygen or nitrogen. A challenge with this process is the transitioning of the target surface between metallic and compound states, causing large fluctuations in film growth rate and composition. At present, there are limited effective methods for real-time monitoring of a material’s chemical state and deposition rate during film formation.

A machine learning technique based on was employed to examine massive emission spectra generated within a reactive sputter plasma. This analysis focused on assessing the state of thin film formation. The results, published in Science and Technology of Advanced Materials: Methods, indicated that the valence state of iron oxide was accurately identified using only the first and second principal components of the spectra. In addition, the film growth rate was predicted with high precision.

RNA modifications control how stem cells develop into retinal cells, research demonstrates

Cells contain a blueprint in the form of DNA that dictates what they can make. This blueprint is converted into a message (mRNA), which is then converted into a protein. Although DNA remains the same in all cells, how it is read depends on specific signals that can change the DNA itself, mRNA or proteins. These signals are often in the form of chemical modifications.

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