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Category: chemistry

A new study led by a pair of researchers at the University of Massachusetts Amherst turns long-held conventional wisdom about a certain type of polymer on its head, greatly expanding understanding of how some of biochemistry’s fundamental forces work. The study, released recently in Nature Communications, opens the door for new biomedical research running the gamut from analyzing and identifying proteins and carbohydrates to drug delivery.

The work involves a kind of polymer made up of neutral polyzwitterions. Because they have a neutral electrical charge, polyzwitterions are not expected to respond to an electric field. However, the team found not only that certain neutral polyzwitterions behave as if they were charged, but also that the electric field surrounding polyzwitterions, once thought to be uniform, varies in strength.

“My interest is in the proteins and , which are the building blocks for protein, inside our body’s cells,” says Yeseul Lee, lead author and graduate student in polymer science and engineering at UMass Amherst.

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A watched pot never boils, goes the old saying, but many of us have at least kept an eye on the pot, waiting for the bubbling to start. It’s satisfying to finally see the rolling boil, behind which complex physical mechanisms are at play.

When this happens, the that form continuously change in shape and size. These dynamic movements influence the surrounding fluid flow, thereby affecting the efficiency of heat transfer from the to the water.

Manipulating small amounts of liquid at high speeds and frequencies is essential for processing large numbers of samples in medical and chemical fields, such as in cell sorting. Microbubble vibrations can create flows and sound waves, aiding in liquid manipulation. However, the and interactions of multiple bubbles is poorly understood, so their applications have been limited.

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Urea, with the formula CO(NH2)2, is a chemical compound that is widely used in a range of sectors, including manufacturing, agriculture and various industries. Conventionally, this compound is produced via a two-step process that entails the synthesis of ammonia from nitrogen (N₂) and its subsequent reaction with carbon dioxide (CO₂).

This reaction occurs at and under , leading to the formation of a compound called ammonium carbamate. This compound is then decomposed at lower pressures, which ultimately produces and water.

Traditional processes for producing urea are very energy intensive, meaning that to produce desired amounts of urea they consume a lot of electrical power. Over the past few years, some engineers have thus been trying to devise more energy-efficient strategies to synthesize urea.

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A team led by Rice University bioscientist Caroline Ajo-Franklin has discovered how certain bacteria breathe by generating electricity, using a natural process that pushes electrons into their surroundings instead of breathing on oxygen.

The findings, published in Cell, could enable in clean energy and industrial biotechnology.

By identifying how these bacteria expel electrons externally, the researchers offer a glimpse into a previously hidden strategy of bacterial life. This work, which merges biology with electrochemistry, lays the groundwork for future technologies that harness the unique capabilities of these microscopic organisms.

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A Kobe University team was able to edit the DNA of Lactobacillus strains directly without a template from other organisms. This technique is indistinguishable from natural variation and enabled the researchers to create a strain that doesn’t produce diabetes-aggravating chemicals.

Humans have improved the microorganisms we rely on for millennia, selecting variants that are better able to produce wine, yogurt, natto and many other products. More recently, direct genetic modification has emerged as a tool to exert more precise and efficient control over the improvement, but also has drawn much public criticism for often using DNA from unrelated organisms in these modifications. Kobe University bioengineer NISHIDA Keiji says, “As a consequence, using such transgenic techniques is not favorable for food products due to legislations being restrictive and social acceptance being low.”

Nishida and his team have developed a technique that gives even more precise control over the genetic content of a microorganism that does not rely on template DNA from other organisms. He says: “We have invented a DNA base editing technology named ‘Target-AID,’ which is superior to conventional techniques such as ‘CRISPR-Cas9’ in several aspects. For example, CRISPR-Cas9 induces DNA breaks and often causes cell death, while our Target-AID inserts precise point mutations without such breaks.”

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Sir Joseph John Thomson (18 December 1856 – 30 August 1940) was an English physicist who received the Nobel Prize in Physics in 1906 “in recognition of the great merits of his theoretical and experimental investigations on the conduction of electricity by gases.” [ 1 ]

In 1897, Thomson showed that cathode rays were composed of previously unknown negatively charged particles (now called electrons), which he calculated must have bodies much smaller than atoms and a very large charge-to-mass ratio. [ 2 ] Thomson is also credited with finding the first evidence for isotopes of a stable (non-radioactive) element in 1913, as part of his exploration into the composition of canal rays (positive ions). His experiments to determine the nature of positively charged particles, with Francis William Aston, were the first use of mass spectrometry and led to the development of the mass spectrograph. [ 2 ] [ 3 ]

Thomson was awarded the 1906 Nobel Prize in Physics for his work on the conduction of electricity in gases. [ 4 ] Thomson was also a teacher, and seven of his students went on to win Nobel Prizes: Ernest Rutherford (Chemistry 1908), Lawrence Bragg (Physics 1915), Charles Barkla (Physics 1917), Francis Aston (Chemistry 1922), Charles Thomson Rees Wilson (Physics 1927), Owen Richardson (Physics 1928) and Edward Victor Appleton (Physics 1947). [ 5 ] Only Arnold Sommerfeld’s record of mentorship offers a comparable list of high-achieving students.

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Depression, schizophrenia and other mental health conditions affect 1 in 4 people in their lifetime, but the mechanisms underlying these conditions are poorly understood. New research led by researchers at the University of Bristol has linked the body’s immune response with schizophrenia, Alzheimer’s disease, depression, and bipolar disorder. The study demonstrates mental health conditions might be affected by the whole body as well as changes in the brain. The findings could pave the way for better treatments of some mental health conditions.

The work appears in Molecular Psychiatry.

Most people with depression or are treated with drugs that work on brain chemicals such as serotonin and dopamine. However, one in three people with these conditions do not benefit from these treatments, suggesting that other mechanisms are involved.

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Traditional biochemical methods of studying human gene mutations are often laborious and costly. Now bioengineers at the University of California San Diego have developed a new simple approach to rapidly check on human gene changes and also screen chemicals as potential drugs by turning everyday bacteria into living test tubes.

The researchers published their new study in the April 30 issue of Nature Biomedical Engineering.

Human cells carry thousands of genes, and tiny changes in these genes can cause serious diseases. Usually, scientists study these changes by testing proteins in a test tube or in human cells. But those methods can be slow, expensive and sometimes hard to do.

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