Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog

Category: chemistry

Exploring metabolic noise opens new paths to better biomanufacturing

Much like humans, microbial organisms can be fickle in their productivity. One moment they’re cranking out useful chemicals in vast fermentation tanks, metabolizing feed to make products from pharmaceuticals and supplements to biodegradable plastics or fuels, and the next, they inexplicably go on strike.

Engineers at Washington University in St. Louis have found the source of the fluctuating metabolic activity in microorganisms and developed tools to keep every microbial cell at peak productivity during biomanufacturing.

The work, published in Nature Communications, tracks hundreds of E. coli cells as they produce a yellow food pigment—betaxanthin—while growing, dividing and carrying out normal metabolic activities.

Do-it-yourself ammonia production: Renewable-powered system uses calcium to reduce emissions and scale for farmers

The last time you scrubbed a streaky window or polished a porcelain appliance, you probably used a chemical called ammonia.

Also known as ammonium hydroxide when mixed with water, ammonia is more than a common household cleaner. More than 170 million metric tons of it are produced globally every year, with most of it ending up as fertilizer for corn, cotton and soybeans.

UIC researchers are scaling up a system for farmers to produce ammonia in their own backyards. The method, which uses renewable electricity and Earth’s natural resources, appears in the journal Proceedings of the National Academy of Sciences.

Moon Missions May Be Polluting Clues to the Origins of Life, Study Warns

Methane released in exhaust could move from one lunar pole to the other in less than two lunar days, with roughly half of it eventually depositing in areas that may preserve the original chemical building blocks linked to the emergence of life on Earth. Over half of the methane released in exhaus

AI and high-throughput testing reveal stability limits in organic redox flow batteries

In numerous scientific fields, high-throughput experimentation methods combined with artificial intelligence (AI) show great promise to accelerate innovation and scientific discovery.

Case in point: In just five months, researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory used robotics, automation and AI to conduct more than 6,000 experiments on chemicals in a type of rechargeable energy storage called organic redox flow batteries (RFBs). Such a monumental effort would have taken five to eight years with traditional experimentation.

Organic RFBs use carbon-based—that is, organic—molecules instead of traditional metal ions. Through their work, the researchers made a crucial finding about these batteries: A fundamental barrier at the molecular level limits their stability. The insight is expected to inspire exciting new directions in battery chemical research.

Collision-induced ribosome degradation driven by ribosome competition and translational perturbations

How cells eliminate inefficient ribosomes.

Inside every cell, ribosomes act as tiny but vital factories that build proteins, translating genetic information into the molecules that sustain life. Although ribosomes share the same basic structure, not all of them work with equal precision. Until now, scientists did not fully understand how cells detect and handle ribosomes that underperform.

Addressing this question, a team of researchers has identified a quality control mechanism that ensures only the most competent ribosomes survive. Their study, published in Nature Communications shows that ribosomes compete during protein synthesis. When translation is disrupted, the less efficient ribosomes are selectively broken down, while the stronger ones continue functioning.

Using biochemical and genetic analyses in yeast, the researchers examined how ribosomes behave when translation is disrupted. The team engineered cells to contain a functional but suboptimal ribosome variant. These slower-moving ribosomes are overtaken on messenger RNA by faster, native ribosomes, causing the two types to collide. Such ribosome-ribosome collisions activate a ubiquitination-dependent quality control pathway that selectively removes the less efficient ribosomes.

The team also explored how external factors, such as the anticancer drug cisplatin affect this process. Cisplatin, known for binding to RNA and DNA, was found to increase ribosome collisions, which in turn promoted ribosome degradation. This insight could improve understanding of how the drug acts inside cells and why it sometimes causes side effects.

The implications of this discovery extend beyond basic biology. By showing how cells maintain the quality of their protein factories, the study provides a foundation for understanding disorders caused by ribosome malfunction, known as ribosomopathies. It may also open the door to new approaches for improving the safety and effectiveness of certain drugs.

Massive impact could be the cause of our lopsided moon

Our nearest neighbor, the moon, is still something of a mystery to us. For decades, scientists have wondered why it appears so lopsided, with dark volcanic plains on the near side (the side we see) and rugged, cratered mountains and a thicker crust on the far side. Now we might be closer to knowing why.

Analysis of lunar soil and rock brought back from the far side by China’s Chang’e-6 mission suggests that a massive impact long ago changed the moon’s interior.

The samples were collected from the South Pole-Aitken basin, a massive impact crater covering nearly one-quarter of the moon’s surface. Because it is so deep, researchers from the Chinese Academy of Sciences wanted to see whether the impact had reached the moon’s mantle and changed its chemistry.

Cyanobacteria can utilize toxic guanidine as a nitrogen source

Guanidine is an organic compound primarily used as a denaturing reagent to disrupt the structures of proteins and nucleic acids. Together with partner institutions, scientists at the Helmholtz Centre for Environmental Research (UFZ) have demonstrated that cyanobacteria, which play a central role in global biogeochemical cycles, use guanidine as a nitrogen source.

The results were recently published in the Proceedings of the National Academy of Sciences. The researchers shed light on the underlying mechanisms and the potential for a new tool for sustainable biotechnological applications.

Q&A: What do scientists need to learn next about blocking enzymes to treat disease?

Enzymes are the molecular machines that power life; they build and break down molecules, copy DNA, digest food, and drive virtually every chemical reaction in our cells. For decades, scientists have designed drugs to slow down or block enzymes, stopping infections or the growth of cancer by jamming these tiny machines. But what if tackling some diseases requires the opposite approach?

Speeding enzymes up, it turns out, is much harder than stopping them. Tarun Kapoor is the Pels Family Professor in Rockefeller’s Selma and Lawrence Ruben Laboratory of Chemistry and Cell Biology. Recently, he has shifted the focus of this lab to tackle the tricky question of how to make enzymes work faster.

Already, his lab has developed a chemical compound to speed up an enzyme that works too slowly in people with a rare form of neurodegeneration. The same approach could open new treatment possibilities for many other diseases where other enzymes have lost function, including some cancers and neurodegenerative disorders such as Alzheimer’s.

NASA Rover Detects Electric Sparks in Mars Dust Devils, Storms

Perseverance confirmed a long-suspected phenomenon in which electrical discharges and their associated shock waves can be born within Red Planet mini-twisters.

NASA’s Perseverance Mars rover has recorded the sounds of electrical discharges —sparks — and mini-sonic booms in dust devils on Mars. Long theorized, the phenomenon has now been confirmed through audio and electromagnetic recordings captured by the rover’s SuperCam microphone. The discovery, published Nov. 26 in the journal Nature, has implications for Martian atmospheric chemistry, climate, and habitability, and could help inform the design of future robotic and human missions to Mars.

A frequent occurrence on the Red Planet, dust devils form from rising and rotating columns of warm air. Air near the planet’s surface becomes heated by contact with the warmer ground and rises through the denser, cooler air above. As other air moves along the surface to take the place of the rising warmer air, it begins to rotate. When the incoming air rises into the column, it picks up speed like spinning ice skaters bringing their arms closer to their body. The air rushing in also picks up dust, and a dust devil is born.

Designer enzyme enables yeast to produce custom fatty acids, reducing need for palm oil

Whether they are laundry detergents, mascara, or Christmas chocolate, many everyday products contain fatty acids from palm oil or coconut oil. However, the extraction of these raw materials is associated with massive environmental issues: Rainforests are cleared, habitats for endangered species are destroyed, and traditional farmers lose their livelihoods.

A research team led by Prof. Martin Grininger at Goethe University in Frankfurt, Germany, has now developed a biotechnological approach that could enable a more environmentally friendly production method. The team’s work appears in Nature Chemical Biology.

/* */