In the intricate machinery of the inner ear, hearing begins with a protein that moves a few billionths of a meter up to 100,000 times per second. That protein, called TMC1, sits at the tips of sensory hair cells deep in the snail-shaped cochlea. When sound waves move these microscopic hairs, TMC1 acts as a channel, opening and allowing charged particles to flow into the cell and trigger an electrical signal to the brain.
Without TMC1, that signal never starts. Mutations in the TMC1 gene are a well-known cause of hereditary hearing loss in humans. Because of this central role, TMC1 is an attractive target for researchers designing gene therapies aimed at restoring hearing. Several groups are testing ways to supply working copies of the gene or fix harmful mutations.
For these efforts to be safe and effective, scientists need to know in detail how TMC1 is built, how it opens, and which parts of the protein are most sensitive to change. However, the hair-cell system that includes TMC1 is so complex, sensitive, and hard to access that it is notoriously difficult to take apart and study directly.
Their mass is extremely low, but how light are neutrinos really? A collaboration comprising German and international research groups has optimized its experiments to determine the mass of these “ghost particles.” In doing so, they succeeded in further adjusting downward the upper limit on the neutrino mass scale that had previously been determined in similar experiments. The study is published in the journal Physical Review Letters.
As part of the “Electron Capture in Ho-163 Experiment” (ECHo), the researchers are using the isotope Holmium-163 (Ho-163), whose decay processes allow for conclusions on the neutrino mass. According to ECHo spokesperson Prof. Dr. Loredana Gastaldo, a scientist at Heidelberg University’s Kirchhoff Institute for Physics, the current results verify that even larger-scale investigations will be feasible in future to get even closer to the mass of neutrinos and ultimately precisely determine it.
Neutrinos are elementary particles with extremely low mass that have no electrical charge. Because their interaction with matter is very weak, the properties of these “ghost particles” are very difficult to determine. This is especially true for the neutrino mass, which has yet to be precisely measured, with only its upper limit being known. According to Gastaldo, determining the mass could pave the way for new theoretical models beyond the standard model of particle physics and thereby contribute to a better understanding of the evolution of our universe.
Why do animals behave differently, and what are the consequences of this? A research team from the Collaborative Research Center NC³ at Bielefeld University and the University of Münster now provides a new explanation: epigenetic processes—chemical markings on DNA—may play a key role. The study, published in the journal Trends in Ecology & Evolution, links individuality, environmental adaptation, genetics, ecology, and evolution in a novel way.
“With our study, we propose that individuality and epigenetic variation influence each other,” explains Dr. Denis Meuthen, an evolutionary biologist at Bielefeld University, who is one of the study’s main authors. “This bidirectionality—this mutual interaction—helps us to better understand ecological and evolutionary processes.”
What can young planets in a far away star system teach astronomers about planetary formation and evolution? This is what a recent study published in The Astrophysical Journal Letters hopes to address as a team of scientists announced the discovery of two young planets orbiting a young star. This study has the potential to help scientists better understand the formation and evolution of planets, along with how solar systems like ours formed and evolved.
For the study, the researchers used the European Southern Observatory’s (ESO’s) Very Large Telescope (VLT) to confirm the existence of a second planet within the WISPIT 2 system, which is located approximately 440 light-years from Earth. The first planet, WISPIT 2b, was identified and confirmed in August 2025, and this new planet has been dubbed WISPIT 2c.
While both planets have been identified as gas giants, WISPIT 2b was confirmed to be approximately five times the mass of Jupiter and orbits at 60 astronomical units (AU) from its star and WISPIT 2c is estimated to be 15 AU from its star and is estimated to be twice the mass as WISPIT 2b. For context, Earth orbits 1 AU from our Sun while Jupiter and Saturn orbit 5.20 AU and 9.58 AU, respectively. Along with the two confirmed planets, the researchers have postulated that a third planet could exist in the system and is estimated to be approximately the mass of Saturn.
A new paper in Genome Biology and Evolution, indicates that while the COVID-19 virus has developed rapidly since 2019, it has done so within limited genetic channels. These genetic limits have remained unchanged. Despite scientists’ earlier fears about dramatic, rapid evolution of the COVID-19 virus, it appears recent changes in the virus were relatively constrained; the virus altered by combining pre-existing mutations. The virus has not expanded the number of genetic routes it can take to evolve.
The paper is titled “Structural constraints acting on the SARS-CoV-2 spike protein reveal limited space for viral adaptation.”
The ALICE Collaboration takes a step further in addressing the question of whether a quark–gluon plasma can be formed in proton–proton and proton–nucleus collisions. In the first few microseconds after the Big Bang, the universe was in an extremely hot and dense state of matter known as quark–gluon plasma (QGP), which can be reproduced with high-energy collisions between heavy ions such as lead nuclei.
In a paper published in Nature Communications, the ALICE Collaboration reports observing a remarkable common pattern in proton–proton, proton–lead and lead–lead collisions at the Large Hadron Collider (LHC), shedding new light on possible QGP formation and evolution in small collision systems.
Physicists initially believed that colliding small systems, such as protons, could not generate the extreme temperatures and pressures needed to form QGP. But in recent years, signatures of QGP have been observed in proton–proton and proton–lead collisions at the LHC, indicating that the size of the collision system may not be a limiting factor in QGP creation.
By reading the chemical “fingerprints” of a distant galaxy, astronomers reconstructed its 12-billion-year evolution. This new method could reveal how galaxies—including our own—were built over cosmic time.
What do we mean with the ‘Big Bang’? Why are the properties of our universe so special? What is cosmological inflation? How can we test cosmological inflation and what do the latest observations tell us? Can we probe string theory using cosmology?
How did our universe come into existence? This basic and ancient question still remains one of the biggest mysteries in science. Ever since Einstein discovered that gravity can be understood as the stretching and bending of space and time, cosmology, which studies the properties, evolution and origin of the universe as a hole, became a proper and honest scientific subject, in which theoretical constructs can be confronted with (cosmological) observations.
What we have learned since then, in less than a century, about the origin and properties of our universe, is spectacular and at the same time mysterious. Our universe appears to be very special. In an attempt to explain these remarkable features a small group of theoretical cosmologists developed the paradigm of cosmological inflation in the eighties. What is cosmological inflation? An what do the latest observations tell us about this fascinating proposal in which all structures in our universe find their origin in small primordial quantum fluctuations? And what are the implications of cosmological inflation for conjectured theories of quantum gravity, such as string theory?
String theorist Jan Pieter van der Schaar argues that cosmology in general, and the cosmological paradigm of inflation in particular, is our best (and perhaps only) bet to probe and test the microscopic quantum description of space and time.
An Pieter van der Schaar is a string theorist by training, with a Ph.D. at the University of Groningen in 2000. After postdoctoral research stints at the University of Michigan, the Cern theory group, and Columbia University, he developed into a theoretical cosmologist with a particular interest to connect cosmological models to string theory and vice versa. Jan Pieter has been a member of the string theory and cosmology group at the Institute of Physics of the University of Amsterdam since 2006. Since 2013 he is the coordinator of the Delta Institute for Theoretical Physics and as of 2022 he is heading the ‘Building Blocks of Matter and Foundations of Space-time’ route as part of the Nationale Wetenschapsagenda.
Project Hail Mary, a story by Andy Weir (author of The Martian), features some of the most creative speculative evolution scenarios in modern science fiction. With the release of the film adaptation starring Ryan Gosling, now seemed like a great time to explore the speculative biology of the aliens in this story: the Astrophage and the Eridians (Rocky’s species).
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Monoamines act as neuromodulators in the nervous system, but their evolutionary origins are unclear. Here, the authors examine the evolution of genes involved in monoamine production, and processing suggesting that the monoaminergic system evolved in the bilaterian stem-group.
