Archive for the ‘neuroscience’ category

Feb 18, 2024

Alzheimer’s disease: Animal study looks at potential new treatment

Posted by in categories: biotech/medical, genetics, neuroscience

A study in mice and nematodes has investigated a potential new therapeutic approach that could help people with the genetic variant that predisposes them to Alzheimer’s disease.

Feb 17, 2024

Donor/recipient enhancement of memory in rat hippocampus

Posted by in categories: mathematics, neuroscience

The critical role of the mammalian hippocampus in the formation, translation and retrieval of memory has been documented over many decades. There are many theories of how the hippocampus operates to encode events and a precise mechanism was recently identified in rats performing a short-term memory task which demonstrated that successful information encoding was promoted via specific patterns of activity generated within ensembles of hippocampal neurons. In the study presented here, these “representations” were extracted via a customized non-linear multi-input multi-output (MIMO) mathematical model which allowed prediction of successful performance on specific trials within the testing session. A unique feature of this characterization was demonstrated when successful information encoding patterns were derived online from well-trained “donor” animals during difficult long-delay trials and delivered via online electrical stimulation to synchronously tested naïve “recipient” animals never before exposed to the delay feature of the task. By transferring such model-derived trained (donor) animal hippocampal firing patterns via stimulation to coupled naïve recipient animals, their task performance was facilitated in a direct “donor–recipient” manner. This provides the basis for utilizing extracted appropriate neural information from one brain to induce, recover, or enhance memory related processing in the brain of another subject.

To understand the neural basis of memory, several features of the context in which the memories occur and are utilized, and the functional aspects of the brain areas involved, need to be identified and controlled (Hampson et al., 2008; Eichenbaum and Fortin, 2009). In prior studies we achieved both of these important contingencies as well as overcoming possible alternative interpretations of the relationship between recorded hippocampal ensemble activity and the behavioral task in which short-term memory formation is necessary (Deadwyler and Hampson, 2006; Deadwyler et al., 2007), and developing an effective mathematical/operational model for online prediction of CA1 hippocampal cell activity from simultaneously recorded input firing patterns from synaptically connected CA3 neurons (Song et al., 2009; Berger et al., 2011; Hampson et al., 2011).

Feb 17, 2024


Posted by in category: neuroscience

Wouldn’t it be wonderful if we could produce happiness by neuro modulation.

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Feb 17, 2024

Ancient viruses emerge as unexpected heroes in vertebrate brain evolution

Posted by in categories: biotech/medical, evolution, neuroscience

Scentists have uncovered a fascinating link between ancient viruses and the development of myelination, the biological process crucial for the advanced functioning of the nervous system in vertebrates, including humans.

Scientists discovered a gene, ‘RetroMyelin,’ from ancient viruses, essential for myelination in vertebrates, suggesting viral sequences in early vertebrate genomes were pivotal for developing complex brains. This breakthrough in Cell unravels how myelination evolved, highlighting its significance in vertebrate diversity.

Feb 17, 2024

Injections of brain protein reverse memory loss in mice

Posted by in categories: biotech/medical, neuroscience

The challenge is huge: There’s a lot we don’t understand about Alzheimer’s disease, but we do know that patient’s brains tend to accumulate toxic tau and amyloid-beta proteins, so most research has focused on those targets.

That approach has led to new drugs that can slow the progression of Alzheimer’s to a small degree, but we’ve yet to find anything that can reverse the damage the disease does to the brain.

The big idea: Synapses — the connections between brain neurons — need a protein called “KIBRA” in order to form memories, and there’s a link between certain variants of the KIBRA gene and developing Alzheimer’s.

Feb 17, 2024

The Mind-Blowing Theory That Challenges Everything We Know

Posted by in categories: neuroscience, quantum physics

Sabine Hossenfelder and Bernardo Kastrup have a theolocution on superdeterminism and free variables.
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Feb 17, 2024

Substance Dualism (Part 2 of 2) [HD]

Posted by in categories: evolution, neuroscience

NB Whilst claims of logical possibility intended to support reality claims (such as Swinburne’s proposal of disembodied existence) become subject to constraints of reality, those not intended to support any reality claim need not be subject to such constraints.

Selected Resources (see also part 1):

Continue reading “Substance Dualism (Part 2 of 2) [HD]” »

Feb 17, 2024

Breakthrough: New Blood Test Predicts Schizophrenia Risk

Posted by in categories: biotech/medical, genetics, neuroscience

Diagnosing schizophrenia as early as possible helps minimize the toll the neurological disorder takes on the body and the mind. Unfortunately the condition’s signs can be difficult to spot in the early stages.

That’s why researchers led by a team from the Indiana University School of Medicine have developed a test which offers a relatively simple and reliable way to check for current schizophrenia severity and future risk.

“Psychosis usually manifests in young adulthood – a prime period of life,” says neuroscientist Alexander Niculescu from the Indiana University School of Medicine. “Stress and drugs, including marijuana, are precipitating factors on a background of genetic vulnerability.”

Feb 17, 2024

Fluicell partners with Swedish researchers to 3D bioprint complex brain cell structures

Posted by in categories: 3D printing, bioprinting, biotech/medical, neuroscience

Scientists from medical tech company Fluicell have partnered with clinical R&D firm Cellectricon and the Swedish Karolinska Institutet university to 3D bioprint neural cells into complex patterns.

Using the microfluidic printheads featured on Fluicell’s Biopixlar platform, the researchers were able to accurately arrange rat brain cells within 3D structures, without damaging their viability. The resulting cerebral tissues could be used to model the progress of neurological diseases, or to test the efficacy of related drugs.

“We’ve been using Biopixlar to develop protocols for the printing of different neuronal cells types, and we are very pleased with its performance,” said Mattias Karlsson, CEO of Cellectricon. “This exciting technology has the potential to open completely new avenues for in-vitro modeling of a wide range of central and PNS-related diseases.”

Feb 16, 2024

Dementia: Could a new blood test predict it 15 years before symptoms?

Posted by in categories: biotech/medical, neuroscience

Researchers are devising a blood test screening for 11 newly discovered biomarkers of dementia. They say the test could predict its development 15 years before symptom onset.

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