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Twenty-four stroke patients have already used the complete system, consisting of an exoskeleton for the arm and shoulder in combination with FES as part of the ReHyb research project. Half of them were patients at the Schön Klinik Bad Aibling Harthausen, which is leading the study. The researchers also used a computer game that automatically adapts to the individual player’s capabilities. It trains them to grip and move their arms shortly after a stroke by reacting to colored balls flying toward them at varying speeds on a screen. The task is to catch the balls and match them with color-coded boxes.

At the center of TUM Professor Sandra Hirche’s setup is a digital twin that records the individual requirements of each patient and places them in a control loop. Among other things, the researchers have to determine how well each patient can move their arm and hand. In the event of a stroke, for example, paralysis can be caused by damage to the motor area in the brain responsible for movement. However, it is impossible to predict how severely the signals transmitted from the brain to the muscles in the forearm will be impaired after the stroke. “Individual muscle strands in the forearm can be stimulated to the right extent for hands and fingers to move,” says Prof. Hirche, who holds the Chair of Information-Oriented Control at TUM. In addition to information on muscle activity in the forearm, the researchers need to know how strongly the muscles should be stimulated in conjunction with the exoskeleton assistance.

Converting one type of cell to another — for example, a skin cell to a neuron — can be done through a process that requires the skin cell to be induced into a “pluripotent” stem cell, then differentiated into a neuron. Researchers at MIT have now devised a simplified process that bypasses the stem cell stage, converting a skin cell directly into a neuron.


MIT researchers devised a process to convert a skin cell directly into a neuron, eliminating the need to generate induced pluripotent stem cells. Such neurons could be used to treat spinal cord injuries or diseases such as ALS.

Firefighters show higher rates of glioma-linked SBS42 mutational signatures associated with haloalkane exposure, suggesting occupational risk. The study highlights a clear link between firefighting, chemical exposure, and brain cancer mutations.

Longevity snapshot 7 — cellular rejuvenation protects neurons.

Reviewing a Canadian study which uses cellular rejuvenation to protect retinal neurons in a mouse model of multiple sclerosis, preserving the vision of the mice.

Study reviewed:

In this manuscript, Drake et al. describe an aging-like transcriptional signature in retinal ganglion cells during experimental autoimmune encephalomyelitis (EAE) like that of cortical neurons in patients with multiple sclerosis. Partial reprogramming with AAV2-Oct4-Sox2-Kl4 to rejuvenate the transcriptome results in improved RGC survival and visual acuity during EAE.

Scientists have made a potentially “life-changing” discovery that could pave the way for new drugs to treat Parkinson’s disease.

Experts have known for several decades that the PINK1 protein is directly linked to Parkinson’s disease – the fastest growing neurodegenerative condition in the world.

Until now, no one has seen what human PINK1 looks like, how PINK1 attaches to the surface of damaged mitochondria inside of cells, or how it is activated.

Speech is a unique human ability that is known to be supported by various motor and cognitive processes. When humans start speaking, they can decide to cease at any point; for instance, if they are interrupted by something happening or by another person speaking to them.

The ability to voluntarily stop speaking plays a central role in social interactions, as it allows people to engage in conversations with others while adaptively responding to social cues, environmental stimuli or interruptions. While many past studies explored the neural and cognitive underpinnings of itself, the brain processes associated with speech inhibition remain poorly understood.

Researchers at the University of California San Francisco recently set out to better understand how the controls the ceasing of speech using tools to record neurophysiological signals. Their paper, published in Nature Human Behaviour, unveils a previously unknown premotor cortical network that could support voluntary speech inhibition.

Yale University, Dartmouth College, and the University of Cambridge researchers have developed MindLLM, a subject-agnostic model for decoding functional magnetic resonance imaging (fMRI) signals into text.

Integrating a neuroscience-informed attention mechanism with a large language model (LLM), the model outperforms existing approaches with a 12.0% improvement in downstream tasks, a 16.4% increase in unseen subject generalization, and a 25.0% boost in novel task adaptation compared to prior models like UMBRAE, BrainChat, and UniBrain.

Decoding into has significant implications for neuroscience and brain-computer interface applications. Previous attempts have faced challenges in predictive performance, limited task variety, and poor generalization across subjects. Existing approaches often require subject-specific parameters, limiting their ability to generalize across individuals.

Scientists have recorded the first-ever brain scan of a dying human.

A man suddenly died during a routine brain scan, revealing intriguing insights into what happens in our final moments.

An 87-year-old man undergoing a routine EEG for epilepsy suffered a fatal heart attack. Researchers found that in the 30 seconds before and after his heart stopped, his brain waves resembled those seen during dreaming, memory recall, and meditation.

This suggests that the commonly reported phenomenon of “life flashing before your eyes” may have a neurological basis. However, since this is a single case study, more research is needed to confirm how common this experience may be.

The findings, published by Dr. Ajmal Zemmar and his team, showed a surge in gamma waves — high-frequency neural oscillations linked to memory and consciousness — just before and after death.

These waves are typically observed when people recall memories, adding weight to the idea that the brain may replay key life events in its final moments. While this discovery cannot fully explain the mysteries of death, it offers a fascinating glimpse into the brain’s last activity and opens the door for further research on human consciousness at the end of life.