Knowing how or why genes are turned on and off during development, as well as understanding how they respond to environmental changes, will prove to be useful in our quest to find ways to prevent diseases. In addition, while the human initiator is responsible for regulating more than half of human genes, there are other sequences that control gene activity. This achievement could lead scientists to discover other sequence signals.
“The solution of the human Initiator code will enable us to explore new frontiers in gene regulation. In the future, it will be possible to use the code to identify other regulatory signals and, in this way, gain a more complete understanding of how human genes are turned on and off,” Kadonaga says.
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