May 3, 2017

Treating Osteoarthritis

Posted by in categories: biotech/medical, life extension

New research in multiple mouse types and human cell lines shows senolytics helps mitigate osteoarthritis.

The removal of senescent cells has shown further potential for the treatment of osteoarthritis in this recent publication where the researchers reduce the impact of post injury osteoarthritis by clearing senescent cells[1]. As we have discussed many times in our publications, senescent cells are a key player in the aging process, if you are new to the subject and want to know what senescent cells are here is a quick primer.

What are senescent cells?

Cellular senescence is a hallmark of aging and is one of the various processes that cause you to age. As you grow older an increasing number of your cells enter into a state known as senescence. These senescent cells no longer divide or support the tissue they are part of, instead they send out a cocktail of harmful chemical signals that cause inflammation and drive the aging process. This proinflammatory collection of proteins, cytokines and signals are known as the senescence associated secretory phenotype (SASP). The SASP blocks various important cellular processes, prevents stem cells from repairing damaged tissue efficiently, and is implicated in the development of age-related diseases[2–3].

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