Researchers at the Scripps Research Institute Florida campus have refined the already state-of-the-art gene-editing system CRISPR. The new improvements boost the ability of CRISPR to target, cut and paste genes in human and animal cells and helps to address the concerns of off target gene mutations raised in a recent study [1].
What is CRISPR?
CRISPR is short for “Clustered Regularly Interspaced Short Palindromic Repeat,” and is a gene editing system that exploits an ancient bacterial immune defense process. Some microbes combat viral infection by sequestering a piece of a virus’ foreign genetic material within its own DNA, to serve as a template. The next time the viral sequence is encountered by the microbe, it is detected immediately and cut up for disposal with the help of two types of RNA. Molecules called guide RNAs show the location of the invader, and the CRISPR effector proteins act as the scissors that cut it apart and destroy it.
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