Jan 30, 2018

Reduced Gbp1 causes mitochondrial dysfunction and cellular senescence in macrophages

Posted by in category: biotech/medical

We have talked about the polarization of macrophages in a number of previous articles, but, in short, macrophages can have multiple behavioral profiles that determine what roles they play; this is known as polarization. A new study has identified a regulatory protein that controls this process.

Macrophage Polarization

For the purposes of this article, we are interested in the M1 and M2 polarization. The M1 type is pro-inflammatory and aggressive towards invading pathogens, while the M2 type of macrophage is anti-inflammatory in nature, suppressing inflammatory responses and facilitating tissue repair.

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