Scientists at the UNC School of Medicine and NC State have created an injectable gel-like scaffold that can hold combination #chemo-immunotherapeutic drugs and deliver them locally to tumors in a sequential manner. The results in animal models so far suggest this approach could one day ramp up therapeutic benefits for patients bearing tumors or after removal of the primary tumors.
The research, published in Science Translational Medicine, focused on two specific types of melanoma and breast #cancer, but this approach could work in other tissue types. Also, the research showed that this localized delivery of combination therapy significantly inhibited the recurrence of cancer after the primary tumor was surgically removed.
“We’ve created a simple method to use #chemotherapy while leveraging the biology of the #tumor and our natural defense against foreign invaders to beat back tumor development with limited side effects,” said senior author Zhen Gu, PhD, associate professor in the joint UNC/NCSU Biomedical Engineering Department. “We have a lot more work to do before human clinical trials, but we think this approach holds great promise.”
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