Oct 30, 2019

‘Protein-Scaffolding’ for Repairing DNA Damage

Posted by in categories: biotech/medical, genetics

At the University of Copenhagen, researchers have discovered how some types of proteins stabilize damaged DNA and thereby preserve DNA function and integrity. This new finding also explains why people with inborn or acquired defects in certain proteins cannot keep their DNA stable and develop diseases such as cancer.

Every day, the body’s cells divide millions of times, and the maintenance of their identity requires that a mother cell passes complete genetic information to daughter cells without mistakes.

This is not a small task because our DNA is constantly under attack, both from the environment but also from the cell’s own metabolic activities. As a result, DNA strands can be broken at least once during each cell division cycle and this frequency can increase by certain lifestyles, such as smoking, or in individuals who are born with defects in DNA repair.

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