Researchers of the Hubrecht Institute (KNAW) in Utrecht, The Netherlands, and the MRC Laboratory of Molecular Biology in Cambridge, United Kingdom, have discovered a new way in which the human body repairs DNA damage caused by a degradation product of alcohol. That knowledge underlines the link between alcohol consumption and cancer. The research groups of Puck Knipscheer and Ketan J. Patel worked together on this study and published the results in the scientific journal Nature on the 4th of March.
Our DNA is a daily target for a barrage of damage caused by radiation or toxic substances such as alcohol. When alcohol is metabolized, acetaldehyde is formed. Acetaldehyde causes a dangerous kind of DNA damage—the interstrand crosslink (ICL)—that sticks together the two strands of the DNA. As a result, it obstructs cell division and protein production. Ultimately, an accumulation of ICL damage may lead to cell death and cancer.
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