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Jul 4, 2020

Scientists develop method to reveal the cell types most affected by genetic variation

Posted by in categories: biotech/medical, genetics, neuroscience

Scientists at Johns Hopkins Medicine have found types of cells in the brain that are most susceptible to inherited genetic variants linked to schizophrenia. As a result, their work reveals a shortlist of the variants that most likely impact disease risk.

Details of the scientists’ analysis, published April 17, 2020, in Genome Research, compared human genetic studies with data on how DNA is folded in , including a diversity of .

“Every common has a major genetic component at its root,” says Andrew McCallion, Ph.D., professor of genetic medicine at the Johns Hopkins University School of Medicine. “Studying genomes across helps us find the genetic landmarks that are linked to disease, but these often don’t give us the biological insight that pinpoints the cells in which that variation acts to impact disease risk.”

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