Sep 5, 2020

Researchers identify nanobody that may prevent COVID-19 infection

Posted by in category: biotech/medical

Researchers at Karolinska Institutet in Sweden have identified a small neutralizing antibody, a so-called nanobody, that has the capacity to block SARS-CoV-2 from entering human cells. The researchers believe this nanobody has the potential to be developed as an antiviral treatment against COVID-19. The results are published in the journal Nature Communications.

“We hope our findings can contribute to the amelioration of the COVID-19 pandemic by encouraging further examination of this nanobody as a therapeutic candidate against this viral infection,” says Gerald McInerney, corresponding author and associate professor of virology at the Department of Microbiology, Tumor and Cell Biology at Karolinska Institutet.

The search for effective nanobodies—which are fragments of antibodies that occur naturally in camelids and can be adapted for humans—began in February when an alpaca was injected with the new ’ spike protein, which is used to enter our cells. After 60 days, from the alpaca showed a strong immune response against the spike protein.

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