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Two or three meters of DNA are packed into each of your cells, but that careful arrangement gets muddled over time, which is one reason we grow old.
SOURCES AND FURTHER READING
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Larson K, Yan SJ, Tsurumi A, Liu J, Zhou J, Gaur K, Guo D, Eickbush TH, Li WX. (2012) Heterochromatin formation promotes longevity and represses ribosomal RNA synthesis. PLoS Genet. 8:e1002473.
Oberdoerffer P, Sinclair DA. (2007) The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol. 8:692–702.
Pegoraro G, Kubben N, Wickert U, Gohler H, Hoffmann K, Misteli T. (2009) Ageing-related chromatin defects through loss of the NURD complex. Nat Cell Biol. 11:1261–1267.
Pollina EA, Brunet A. (2011) Epigenetic regulation of aging stem cells. Oncogene 30:3105–3126.
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