A group of scientists has developed an entirely new approach to treating eating disorders.
They showed that a group of nerve cells (so-called AgRP, agouti-related peptide neurons) in the hypothalamus control the release of endogenous lysophospholipids, which in turn control the excitability of nerve cells in the cerebral cortex, which stimulates food intake.
In this process, the crucial step of the signaling pathway is controlled by autotaxin, an enzyme that is responsible for the production of lysophosphatidic acid.
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