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Aug 24, 2022

Gasdermin D pores are dynamically regulated by local phosphoinositide circuitry

Posted by in category: genetics

Basically this means halting and controlling cellular death which would reverse the death process :3.


During pyroptosis, gasdermin D (GSDMD) forms plasma membrane pores that initiate cell lysis. Here, the authors develop optogenetically activatable human GSDMD to assess GSDMD pore behavior and show that they are dynamic and can close, which can be a pyroptosis regulatory mechanism.

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