Toggle light / dark theme

Chemists Discover Why Synonymous DNA Mutations Are Not Always Silent

Modeling shows how genetic changes that don’t lead to changes in protein sequence can still alter protein function.

New modeling shows how synonymous mutations — those that change the DNA

DNA, or deoxyribonucleic acid, is a molecule composed of two long strands of nucleotides that coil around each other to form a double helix. It is the hereditary material in humans and almost all other organisms that carries genetic instructions for development, functioning, growth, and reproduction. Nearly every cell in a person’s body has the same DNA. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA or mtDNA).