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Dec 29, 2022

Serotonin Deficiency Directly Linked With Depression in Groundbreaking Study

Posted by in category: neuroscience

New research in Biological Psychiatry offers the first direct evidence of diminished 5-HT release cements “serotonin hypothesis.”

Researchers have postulated since the 1960s that major depression stems from disruptions in the serotonin neurotransmitter system. However, the evidence for that idea, though plentiful, was indirect. In fact, a recent comprehensive analysis of existing studies concluded that there was not strong evidence to support the “serotonin hypothesis.” In its wake, some in the field have called for a reexamination of the hypothesis. Not so fast, says a new study that provides direct evidence of disrupted serotonin release in the brains of individuals with depression.

The study was published recently in the journal Biological Psychiatry.

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