UNIGE researchers have discovered that a medication commonly used to treat herpes can combat an antibiotic-resistant bacterium by disrupting its defense mechanisms.
Antibiotic resistance, or the ability of bacteria to develop resistance to treatment with antibiotics, has become a major concern for global health. The World Health Organization (WHO) considers it one of the greatest threats to health. The overuse of antibiotics has contributed to the emergence of antibiotic-resistant bacteria, which can cause serious illness and death. One example of an antibiotic-resistant pathogen is Klebsiella pneumoniae, a bacterium commonly found in hospitals and known for its virulence. Without effective treatment options, we could see a resurgence of diseases such as pneumonia and salmonella, which were once easily treated with antibiotics.
Researchers at the University of Geneva (UNIGE) have found that edoxudine, an anti-herpes molecule developed in the 1960s, can disrupt the protective surface of Klebsiella bacteria and make them more vulnerable to being eliminated by immune cells. The researchers’ findings were recently published in the journal PLOS ONE.
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