БЛОГ

Jun 26, 2023

Curcumin Loaded Dendrimers Specifically Reduce Viability of Glioblastoma Cell Lines

Posted by in category: biotech/medical

Paper published in Molecules (ISSN 1420–3049) discusses the efficient delivery of curcumin, a well-known anti-inflammatory antioxidant, as a potential candidate for glioblastoma (GB) treatment.

Access the paper👇.


Glioblastoma (GB) is a deadly and aggressive cancer of the CNS. Even with extensive resection and chemoradiotherapy, patient survival is still only 15 months. To maintain growth and proliferation, cancer cells require a high oxidative state. Curcumin, a well-known anti-inflammatory antioxidant, is a potential candidate for treatment of GB. To facilitate efficient delivery of therapeutic doses of curcumin into cells, we encapsulated the drug in surface-modified polyamidoamine (PAMAM) dendrimers. We studied the in vitro effectiveness of a traditional PAMAM dendrimer (100% amine surface, G4 NH2), surface-modified dendrimer (10% amine and 90% hydroxyl-G4 90/10-Cys), and curcumin (Cur)-encapsulated dendrimer (G4 90/10-Cys-Cur) on three species of glioblastoma cell lines: mouse-GL261, rat-F98, and human-U87.

Comments are closed.