Aug 1, 2023

DNA framework-engineered chimeras platform enables selectively targeted protein degradation

Posted by in category: biotech/medical

The lack of a universal platform for PROTAC development remains a major bottleneck. Here, the authors report modular DNA framework-based PROTACs (DbTACs) that enable precise control of the linker length and selective degradation of diverse targets in different cellular compartments using various warheads.

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