Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide in clinical samples in a range of drug-resistant bacteria.
Now scientists have captured the first images of one important class of these enzymes in action. The images show how the enzymes latch onto a particular site on the bacterial ribosome and squeeze it like a pair of tweezers to extract an RNA nucleotide and alter it. The Proceedings of the National Academy of Sciences (PNAS) published the findings, led by scientists at Emory University.
The advanced technique of cryoelectron microscopy made the ultra-high-resolution, three-dimensional snapshots possible.
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