In the Lord of the Rings, there was “one ring to rule them all.” Now, a team of researchers is developing their own single ruler, an approach to CAR T-cell therapy that could treat all forms and types of blood cancer.
In experiments in mouse models of different blood cancers, the treatment rapidly eliminated tumors, including in mice with acute myeloid leukemia (AML), a difficult-to-treat type of blood cancer for which researchers have struggled to develop effective immunotherapies.
There was also no evidence of serious side effects in the animals. And, finally—and distinctly from the standard approach to current CAR T-cell therapies—it provided the mice with a healthy supply of new blood cells.
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