Bonn researchers identify protein that increases the formation of good brown and beige fat. Brown fat cells convert energy into heat — a key to eliminating unwanted fat deposits. In addition, they also protect against cardiovascular diseases. Researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Area “Life & Health” at the University of Bonn have now identified the protein EPAC1 as a new pharmacological target to increase brown fat mass and activity. The long-term aim is to find medicines that support weight loss. The results of the study have now been published in the journal Nature Cell Biology.
Obesity is defined as a pathological increase in white fat, and has become a major problem worldwide, with a greatly increased risk of cardiovascular diseases such as heart attack and stroke.
“Exercise and dieting are not enough to effectively and permanently shed the pounds,” says corresponding author Prof.
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