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Jan 14, 2024

Why do antidepressants take so long to kick in?

Posted by in categories: biotech/medical, neuroscience

Have you ever wondered why SSRIs take time to show effects? A new study has delved into why antidepressants like SSRIs take weeks to start working and how this may impact mental health care.


SSRIs, or Selective Serotonin Reuptake Inhibitors, belong to a category of antidepressant drugs designed to elevate serotonin levels in the brain. Notable examples of SSRIs include fluoxetine (Prozac), sertraline (Zoloft), and escitalopram (Lexapro).

These medications generally have few unpleasant side effects and can be highly effective in treating various mood disorders, including depression and certain anxiety disorders. However, one significant drawback of SSRIs is the delayed onset of their therapeutic effects — SSRIs often take several weeks to show noticeable improvements in mood.

This extended period before “kicking in” poses challenges for patients and healthcare providers. Yet, the reason behind this lag in action is not well understood.

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