Mar 24, 2024

Study supports hypothesis that mitochondrial dysregulation is a contributor to the development of schizophrenia

Posted by in categories: bioengineering, biotech/medical, genetics, neuroscience

Researchers at Rutgers and Emory University are gaining insights into how schizophrenia develops by studying the strongest-known genetic risk factor.

When a small portion of chromosome 3 is missing—known as 3q29 deletion syndrome—it increases the risk for by about 40-fold.

Researchers have now analyzed overlapping patterns of altered gene activity in two models of 3q29 deletion syndrome, including mice where the deletion has been engineered in using CRIPSR, and , or three-dimensional tissue cultures used to study disease. These two systems both exhibit impaired . This dysfunction can cause energy shortfalls in the brain and result in psychiatric symptoms and disorders.

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