The research team found that long-term urolithin A treatment in mice significantly improved their learning, memory and olfactory function. The treatment also reduced amyloid beta (Aβ) and tau pathologies and improved cellular lysosomal function [1].
The researchers’ findings also suggest that urolithin A is as effective as NAD in promoting mitophagy, positioning it as a potential therapeutic agent for Alzheimer’s disease.
“Our study on mouse models with AD shows that urolithin A, which is a naturally occurring substance in pomegranates, can alleviate memory problems and other consequences of dementia,” says Bohr. “Even though the study was conducted on mouse models, the prospects are positive. So far, research has shown promising results for the substance in the muscles, and clinical trials on humans are being planned [3].”
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