БЛОГ

Jul 21, 2024

Lab-grown human neuron assembloids effectively model synaptic plasticity

Posted by in categories: biotech/medical, neuroscience

The ability to study human neurological systems depends on having viable, accurate models of brain function. St. Jude researchers have now created a model for such research by combining thalamic cells and cortical cells derived from human induced pluripotent stem cells.

The thalamocortical system mediates multiple sensory and , such as perception, learning and memory. The researchers developed a model of a primitive human thalamocortical system by maintaining thalamic and cortical cell masses known as organoids in close proximity in a culture dish.

In this model, the neurons in both organoids develop and grow long-ranging processes (axons) that extend to the opposite organoid and form functional connections (synapses). The researchers determined that when these synapses are stimulated, they undergo long-term strengthening and weakening of their electrical signals, which is the hallmark of , a process that underlies certain forms of learning and memory.

Leave a reply