In a rat experiment, researchers publishing in Aging Cell have found that senescent cells and SASP factors are key in regenerating knee cartilage.
Not always negative
Cellular senescence is widely known to have negative effects, to the point that it is one of the hallmarks of aging. In fact, rather than protecting cartilage, cellular senescence has been reported to damage it in the progression of osteoarthritis [1]. However, the idea that senescence is beneficial for regeneration is not a new concept [2], and it has been found to assist wound healing in mice [3]. Understanding everything involved in this complex relationship is not easy, and one of the factors appears to be windows of time [4].
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