A new study from The Hospital for Sick Children (SickKids) and Institut Curie reveals how stem cells sense and respond to their environment, with implications for inflammatory bowel disease and colorectal cancer.
Stem cells constantly adapt to their environment to maintain organ and tissue health, informed by chemical signals and physical forces. When they do not function as intended, stem cells can result in a number of health conditions including inflammatory bowel disease (IBD) and colorectal (bowel) cancer, where they continue to divide until a tumor forms.
Until now, how stem cells sense the physical forces around them has remained unclear, but novel findings published in Science led by Dr. Meryem Baghdadi, a former SickKids postdoctoral researcher, Dr. Tae-Hee Kim at SickKids and Dr. Danijela Vignjevic at Institut Curie, has revealed that stem cells depend on two ion channels, called PIEZO1 and PIEZO2, for their survival.
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