Lifeboat Foundation

New research by UCSF scientists could accelerate – by 10 to 100-fold – the pace of many efforts to profile gene activity, ranging from basic research into how to build new tissues from stem cells to clinical efforts to detect cancer or auto-immune diseases by profiling single cells in a tiny drop of blood.

The study, published online April 27, 2016, in the journal Cell Systems, rigorously demonstrates how to extract high-quality information about the patterns of gene expression in individual cells without using expensive and time-consuming deep-sequencing technology. The paper’s senior authors are Hana El-Samad, PhD, an associate professor of biochemistry and biophysics at UCSF, and Matt Thomson, PhD, a faculty fellow in UCSF’s Center for Systems and Synthetic Biology.

“We believe the implications are huge because of the fundamental tradeoff between depth of sequencing and throughput, or cost,” said El-Samad. “For example, suddenly, one can think of profiling a whole tumor at the single cell level.”

Continue reading “Math points to 100-times faster mapping of gene activity” »

In a new study, researchers detail the culturing and transfecting of cells with genetic material on an array of carbon nanotubes, which appears to overcome the limitations of other gene editing technologies.

Gene editing techniques hold great promise. They allow targeted and specific edits of genes, and have nearly limitless possibilities in the field of medicine.

Which is not to say that they are perfect. These techniques still have a range of limitations, from precision to toxicity. But a new study shows that can be changed.

Continue reading “Gene Editing Made Easier, Thanks to Carbon Nanotubes” »

Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.

This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.

Continue reading “Bioquark Inc. and Revita Life Sciences Receive IRB Approval for First-In-Human Brain Death Study” »

CRISPR to improve shelf life of vegetables and fruits. I magine what this would mean for populations in remote locations with horrible climates or in disaster zones that need fresh foods.

Yinong Yang, a Penn State University researcher, has used a famous gene editing tool known as CRISPR/Cas9 for cutting out a small piece of DNA from one specific gene in a white button mushroom. With this, Yang was able to stop the gene, which in turn cuts the production of an enzyme known as polyphenol oxidase in mushroom. With this gene editing of white mushrooms, the mushroom doesn’t get spoiled as natural mushrooms.

You might have heard something like this earlier as scientists have also developed non-browning versions of apples and potatoes. However, those crops were called GMOs as scientists had put in new, slightly altered genes within those plants to ‘silence’ the natural gene.

Continue reading “Penn Researcher uses CRISPR/Cas9 to snip out tiny piece of DNA from gene in white button mushroom” »

Another gene editing triumph.

Genetic engineering may emerge as an important tool to avert extinctions. But ecosystems are complex, and this tinkering might not unfold as planned.

I was asked recently if I had money given to me to invest in anything that would result in the betterment of people what would that be. I quickly shared “Gene Editing” such as CRISPR and Quantum. These 2 areas is changing our lives over the next 7 to 10 years in ways that we have only dreamed about. I love this article.

TENS of thousands of blind people could have their sight restored after scientists discovered how to manipulate genes at the back of the eyes.

(Phys.org)—A new study shows that a swarm of hundreds of thousands of tiny microbots, each smaller than the width of a human hair, can be deployed into industrial wastewater to absorb and remove toxic heavy metals. The researchers found that the microbots can remove 95% of the lead in polluted water in one hour, and can be reused multiple times, potentially offering a more effective and economical way to remove heavy metals than previous methods.

The researchers, Diana Vilela, et al., have published a paper on the lead-adsorbing microbots in a recent issue of Nano Letters.

“This work is a step toward the development of smart remediation system where we can target and remove traces of pollutant without producing an additional contamination,” coauthor Samuel Sánchez, at the Max-Planck Institute for Intelligent Systems in Stuttgart, Germany; the Institute for Bioengineering of Catalonia in Barcelona; and the Catalan Institution for Research and Advanced Studies in Barcelona, told Phys.org.

Continue reading “Microbots can clean up polluted water” »

Luv it; AI (more than any other technology) as well as Gene editing needs diversity in order to have relevance in the world.

We need Black intellligence.

Depends who is doing the creating. If a robot is created/ altered by ISIS to attack the western world then robots. At the same time, if a crazy scientist decides to genetically create Cyclops to take over the UK, US, etc. then the genetically alter species. Truly depends on the creator and the creator’s eye.

At Silicon Valley’s inaugural Comic Con, we gave a talk called “Superbabies vs. AI.” Astro, who is captain of moonshots at Alphabet’s X division, argued that genetically engineered babies are going to destroy civilization as we know it. He sees the horror of eugenics, X-Men, and a planet entirely populated by the sort of kids who beat him up in middle school, all rolled into one. Danielle, a physician-scientist and wife of said captain of moonshots, argued that the robot apocalypse is going to annihilate humanity. Super intelligent computers will eventually destroy us all, no matter what sort of Asimovian instructions we try to give them. The jury is out about who won the debate, but here are the most important issues we explored.

Will highly evolved AI break into banking systems and steal all of our money or send drones to kill us all?

Continue reading “What will destroy us first: Superbabies or AI?” »