Lifeboat Foundation

Thru Gene Editing could we some day see no more murderers?

FOR MOST of us, understanding how mass murderers can kill without remorse is an impossible feat.

Now, that’s an exhibit!

May 5, 2016, will mark the opening of a new and exciting exhibit at Chicago’s famed Museum of Science and Industry: an in-depth and interactive look behind the curtain at the Defense Advanced Research Projects Agency (DARPA).

DARPA was created in 1958 at the peak of the Cold War in response to the Soviet Union’s launch of Sputnik, the world’s first manmade satellite, which passed menacingly over the United States every 96 minutes. Tasked with preventing such strategic surprises in the future, the agency has achieved its mission over the years in part by creating a series of technological surprises of its own, many of which are highlighted in the Chicago exhibit, “Redefining Possible.”

“We are grateful to Chicago’s Museum of Science and Industry for inviting us to tell the DARPA story of ambitious problem solving and technological innovation,” said DARPA Deputy Director Steve Walker, who will be on hand for the exhibit’s opening day. “Learning how DARPA has tackled some of the most daunting scientific and engineering challenges—and how it has tolerated the risk of failure in order to have major impact when it succeeds—can be enormously inspiring to students. And for adults, we hope the exhibit will serve as a reminder that some of the most exciting work going on today in fields as diverse as chemistry, engineering, cyber defense and synthetic biology are happening with federal support, in furtherance of pressing national priorities.”

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Excellent read and a true point about the need for some additional data laws with our ever exploding information overload world.

Laws for Mobility, IoT, Artificial Intelligence and Intelligent Process Automation

If you are the VP of Sales, it is quite likely you want and need to know up to date sales numbers, pipeline status and forecasts. If you are meeting with a prospect to close a deal, it is quite likely that having up to date business intelligence and CRM information would be useful. Likewise traveling to a remote job site to check on the progress of an engineering project is also an obvious trigger that you will need the latest project information. Developing solutions integrated with mobile applications that can anticipate your needs based upon your Code Halo data, the information that surrounds people, organizations, projects, activities and devices, and acting upon it automatically is where a large amount of productivity gains will be found in the future.

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Scientists are now one step closer to neutralizing HIV.

In a study conducted at Vanderbilt University and published in Proceedings of the National Academy of Sciences, researchers isolated antibodies with a loop-like structure that binds tightly to HIV and disables it. Unlike traditional vaccines, which jump-start an immune response by exposing the patient to a pathogen, this newly discovered method could work even in people who have not previously been exposed to by the virus.

Using computer modeling, the researchers identified the amino acid sequences that bound most tightly to HIV and re-engineered them in an optimal sequence that simulated vaccination.

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New research by UCSF scientists could accelerate – by 10 to 100-fold – the pace of many efforts to profile gene activity, ranging from basic research into how to build new tissues from stem cells to clinical efforts to detect cancer or auto-immune diseases by profiling single cells in a tiny drop of blood.

The study, published online April 27, 2016, in the journal Cell Systems, rigorously demonstrates how to extract high-quality information about the patterns of gene expression in individual cells without using expensive and time-consuming deep-sequencing technology. The paper’s senior authors are Hana El-Samad, PhD, an associate professor of biochemistry and biophysics at UCSF, and Matt Thomson, PhD, a faculty fellow in UCSF’s Center for Systems and Synthetic Biology.

“We believe the implications are huge because of the fundamental tradeoff between depth of sequencing and throughput, or cost,” said El-Samad. “For example, suddenly, one can think of profiling a whole tumor at the single cell level.”

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In a new study, researchers detail the culturing and transfecting of cells with genetic material on an array of carbon nanotubes, which appears to overcome the limitations of other gene editing technologies.

Gene editing techniques hold great promise. They allow targeted and specific edits of genes, and have nearly limitless possibilities in the field of medicine.

Which is not to say that they are perfect. These techniques still have a range of limitations, from precision to toxicity. But a new study shows that can be changed.

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Bioquark, Inc., (http://www.bioquark.com) a company focused on the development of novel biologics for complex regeneration and disease reversion, and Revita Life Sciences, (http://revitalife.co.in) a biotechnology company focused on translational therapeutic applications of autologous stem cells, have announced that they have received IRB approval for a study focusing on a novel combinatorial approach to clinical intervention in the state of brain death in humans.

This first trial, within the portfolio of Bioquark’s Reanima Project (http://www.reanima.tech) is entitled “Non-randomized, Open-labeled, Interventional, Single Group, Proof of Concept Study With Multi-modality Approach in Cases of Brain Death Due to Traumatic Brain Injury Having Diffuse Axonal Injury” (https://clinicaltrials.gov/ct2/show/NCT02742857?term=bioquark&rank=1), will enroll an initial 20 subjects, and be conducted at Anupam Hospital in Rudrapur, Uttarakhand India.

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CRISPR to improve shelf life of vegetables and fruits. I magine what this would mean for populations in remote locations with horrible climates or in disaster zones that need fresh foods.

Yinong Yang, a Penn State University researcher, has used a famous gene editing tool known as CRISPR/Cas9 for cutting out a small piece of DNA from one specific gene in a white button mushroom. With this, Yang was able to stop the gene, which in turn cuts the production of an enzyme known as polyphenol oxidase in mushroom. With this gene editing of white mushrooms, the mushroom doesn’t get spoiled as natural mushrooms.

You might have heard something like this earlier as scientists have also developed non-browning versions of apples and potatoes. However, those crops were called GMOs as scientists had put in new, slightly altered genes within those plants to ‘silence’ the natural gene.

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Another gene editing triumph.

Genetic engineering may emerge as an important tool to avert extinctions. But ecosystems are complex, and this tinkering might not unfold as planned.