Lifeboat Foundation

In April 2015, a paper by Chinese scientists about their attempts to edit the DNA of a human embryo rocked the scientific world and set off a furious debate. Leading scientists warned that altering the human germ line without studying the consequences could have horrific consequences. Geneticists with good intentions could mistakenly engineer changes in DNA that generate dangerous mutations and cause painful deaths. Scientists — and countries — with less noble intentions could again try to build a race of superhumans.

Human DNA is, however, merely one of many commercial targets of ethical concern. The DNA of every single organism — every plant, every animal, every bacterium — is now fair game for genetic manipulation. We are entering an age of backyard synthetic biology that should worry everybody. And it is coming about because of CRISPRs: clustered regularly interspaced short palindromic repeats.

Discovered by scientists only a few years ago, CRISPRs are elements of an ancient system that protects bacteria and other single-celled organisms from viruses, acquiring immunity to them by incorporating genetic elements from the virus invaders. CRISPRs evolved over millions of years to trim pieces of genetic information from one genome and insert it into another. And this bacterial antiviral defense serves as an astonishingly cheap, simple, elegant way to quickly edit the DNA of any organism in the lab.

Continue reading “Gene Editing Is Now Cheap and Easy—and No One Is Prepared for the Consequences” »

Lifespan.io is running a SENS fundraiser to aid research into Mitochondrial repair. This is a new fundraiser platform to help get important regenerative medicine research funded and underway. Let us hope this is the start of how research could be funded and that it opens up faster progress.

Engineering backup copies of mitochondrial genes to place in the nucleus of the cell, aiming to prevent age-related damage and restore lost mitochondrial function.

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Synthetic biology is radical and has huge potential to revolutionize multiple industries. The fact is biology has already worked out efficient ways of doing things, or has in place mechanisms we can adapt, so why reinvent anything if we can simply adapt what’s already here? Using billions of years of evolution makes logical sense, and that’s what synthetic biology builds on.

So here is a great video by Grist, explaining what synthetic biology is and what we might be able to do with it in the future.

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“We have a few cyborgs on staff. Ben Popper is arguably the reporter best known for peeling back his skin to insert a piece of technology, which he chronicled in his feature, Cyborg America. But others have gone under the knife. I wanted to know why. You know, because I have crippling FOMO.”

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Wyss Institute scientists believe that synthetic gene drives, if researched responsibly, might be used in the future to render mosquito populations unable to transmit malaria (credit: CDC)

An international group of 26 experts, including prominent genetic engineers and fruit fly geneticists, has unanimously recommended a series of preemptive measures to safeguard gene drive research from accidental (or intentional) release from laboratories.

RNA-guided gene drives are genetic elements — found naturally in the genomes of most of the world’s organisms — that increase the chance of the gene they carry being passed on to all offspring. So they can quickly spread through populations if not controlled.

Continue reading “Move over, autonomous AI weapons, there’s a new risk in town: ‘gene drives’” »

The Millennium Project released today its annual “2015–16 State of the Future” report, listing global trends on 28 indicators of progress and regress, new insights into 15 Global Challenges, and impacts of artificial intelligence, synthetic biology, nanotechnology and other advanced technologies on employment over the next 35 years.

“Another 2.3 billion people are expected to be added to the planet in just 35 years,” the report notes. “By 2050, new systems for food, water, energy, education, health, economics, and global governance will be needed to prevent massive and complex human and environmental disasters.”

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Scientists have been experimenting with brain-to-brain interfaces for years. Miguel Nicolelis, a neurobiologist at Duke University Medical Center, has created a “Brainet” or a network of interconnected brains with four rats. With electrodes implanted directly in the cortex rodents exchange information to create an organic computing device. Collectively, they were able to solve computational problems including image processing, storing and recalling information and even predicting precipitation.

Read the full story by Mona Lalwani at Engadget

A team of bioengineers at Brigham and Women’s Hospital (BWH), led by Ali Khademhosseini, PhD, and Nasim Annabi, PhD, of the Biomedical Engineering Division, has developed a new protein-based gel that, when exposed to light, mimics many of the properties of elastic tissue, such as skin and blood vessels. …

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The Pentagon is working on technology that will allow it to engineer a new organism within a day of it being found in the wild.

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