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Category: bioengineering – Page 135

I20 Therapeutics Wants To Replace The Syringe With A Pill For Diabetes

The Harvard University offshoot i20 Therapeutics is setting the goal of one day having those who suffer from diabetes to be able to treat it with pills rather than injections with a syringe when they need to take their medications.

Bioengineering researchers began to publish their methods in 2018 for turning liquid medications into encapsulated easy to swallow forms, which has demonstrated some early success with insulin in animal models.

Starting out with $4 million in seed money from Sanofi Ventures and the Juvenile Diabetes Research Foundation’s T1D Fund, i20 Therapeutics plans to take that technology to GLP1 analogs, these are the glucagon like peptides that help to maintain blood sugar levels; i20 is focused on creating the next generation of oral peptide and protein based therapies.

The future is nano, and it will revolutionise medical science Essays

If you’ve been interested in nanotech, but have been too afraid to ask, here is an introductory and interesting article that I’d like to recommend.

My interest in nanotech is based on my hope that nanotech can lead to methods of constructing substrates that are suitable for mind uploading. It may lead to a technique to create duplicate minds.

“These ‘biological engineering’ technologies have made real one of the dreams of the nanotechnology pioneers: the deployment of molecular assemblers able to construct any shape with atomic precision, following a rational design.”

“…hybrid bioinorganic devices that mimic biological processes will soon be used in new computers and electronic devices.”

In the mid-1980s, evidence started to emerge from labs across the world confirming that scientists were finally able to reach the nano level in experimental conditions and not just with their theories. Working at scales defined in millionths of a millimetre, Richard Smalley, Robert Curl and Harold Kroto reported the discovery of ‘buckminsterfullerene’ – a nanosized polyhedron, with 32 faces fused into a cage-like, soccer-ball structure, and with carbon atoms sitting in each of its 60 vertices.

These miniature ‘Bucky’ balls (named for their similarity to the geodesic dome structures made by the architect R Buckminster Fuller in the 1950s), are found in tiny quantities in soot, in interstellar space and in the atmospheres of carbon-rich red giant stars, but Kroto was able to recreate them in chemical reactions in the lab while visiting Rice University in Texas. Then, in 1991, Nadrian Seeman’s lab at New York University used 10 artificial strands of DNA to create the first human-made nanostructure, connecting up the DNA strands to resemble the edges of a cube, so marking the beginning of the field now known as ‘DNA nanotechnology’. Clever scientists with broad visions started to realise that a new kind of technology, prophesied by Richard Feynman in the 1950s, was finally materialising, as researchers achieved the capacity to visualise, fabricate and manipulate matter at the nanometre scale.

Continue reading “The future is nano, and it will revolutionise medical science Essays” | >

New genetic engineering strategy makes human-made DNA invisible

Scientists can identify pathogenic genes through genetic engineering. This involves adding human-made DNA into a bacterial cell. However, the problem is that bacteria have evolved complex defense systems to protect against foreign intruders — especially foreign DNA. Current genetic engineering approaches often disguise the human-made DNA as bacterial DNA to thwart these defenses, but the process requires highly specific modifications and is expensive and time-consuming.

In a paper published recently in the Proceedings of the National Academy of Sciences journal, Dr. Christopher Johnston and his colleagues at the Forsyth Institute describe a new technique to genetically engineer bacteria by making human-made DNA invisible to a bacterium’s defenses. In theory, the method can be applied to almost any type of bacteria.

Johnston is a researcher in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center and lead author of the paper. He said that when a bacterial cell detects it has been penetrated by foreign DNA, it quickly destroys the trespasser. Bacteria live under constant threat of attack by a virus, so they have developed incredibly effective defenses against those threats.

Religious beliefs shape our thinking on cloning, stem cells and gene editing

Christian views tend to be more prohibitive compared with other religions.

It is difficult to examine society’s acceptance or rejection of key biotech developments without considering the role played by the world’s major religions and their belief structures.

Christianity, Judaism, Hinduism, Buddhism and Islam react to new technologies and concepts in their own way – though there is rarely universal consensus on every issue within those religions. Not surprisingly, the basis for modern day beliefs is often found in scripture and related lore.

To better understand, for example, how religions view the use of human embryonic tissue for research and treatment, consider the ancient Jewish tales of golemim — super beings created by humans for protection and tasks.

Team develops photosynthetic proteins for expanded solar energy conversion

A team of scientists, led by the University of Bristol, has developed a new photosynthetic protein system enabling an enhanced and more sustainable approach to solar-powered technological devices.

The initiative is part of a broader effort in the field of to use proteins in place of man-made materials which are often scarce, expensive and can be harmful to the environment when the device becomes obsolete.

The aim of the study, published today in Nature Communications, was the development of “chimera” complexes that display poly-chromatic solar energy harvesting.

Elon Musk: Should Have 1000 Ventilators Next Week, + 250,000 N95 Masks For Hospitals Tomorrow Exclusive

Dr. Ezekiel Emanuel, an American oncologist and bioethicist who is senior fellow at the Center for American Progress as well as Vice Provost for Global Initiatives at the University of Pennsylvania and chair of the Department of Medical Ethics and Health Policy, said on MSNBC on Friday, March 20, that Tesla and SpaceX CEO Elon Musk told him it would probably take 8–10 weeks to get ventilator production started at his factories (he’s working on this at Tesla and SpaceX).

I reached out to Musk for clarification on that topic and he replied that, “We have 250k N95 masks. Aiming to start distributing those to hospitals tomorrow night. Should have over 1000 ventilators by next week.” With medical supplies such as these being one of the biggest bottlenecks and challenges at the moment in the COVID-19 response in the United States (as well as elsewhere) — something that is already having a very real effect on medical professionals and patient care — the support will surely be received with much gratitude. That said, while there has been much attention put on the expected future need for ventilators, very few places reportedly have a shortage of them right now. In much greater need at the moment are simpler supplies like N95 masks, which must be why Tesla/SpaceX is providing 250,000 of them.

Dr. Emanuel also said in the segment of MSNBC’s “Morning Joe” he was on that we probably need 8–12 weeks (2–3 months) of social distancing in the US in order to deal with COVID-19 as a society. However, he also expects that the virus will come back and we’ll basically have a roller coaster of “social restrictions, easing up, social restrictions, easing up … to try to smooth out the demand on the health care system.”

The new coronavirus was not genetically engineered, study shows

Josie Golding, Ph.D., who is the epidemics lead at the Wellcome Trust, a research charity based in London, United Kingdom, did not participate in the study but comments on its significance.

She says the findings are “crucially important to bring an evidence-based view to the rumors that have been circulating about the origins of the virus (SARS-CoV-2) causing COVID-19.”

“[The authors] conclude that the virus is the product of natural evolution,” Goulding adds, “ending any speculation about deliberate genetic engineering.”